Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1970 Feb;45(239):73–79. doi: 10.1136/adc.45.239.73

Carbohydrate-induced Hypertriglyceridaemia in a Child*

M M Segall, Audrey S Fosbrooke, June K Lloyd, O H Wolff
PMCID: PMC2020387  PMID: 5440210

Abstract

Carbohydrate-induced hypertriglyceridaemia is described in a 12-year-old boy, whose father died of premature coronary heart disease. Serum triglyceride and pre-fl-lipoprotein concentrations were high on a self-selected diet and were reduced to normal by a low carbohydrate diet. It proved difficult to maintain triglyceride levels by diet at home, but the addition of clofibrate improved the control.

Clearing of lipid from the serum after an oral fat load was delayed when the fasting serum triglyceride was high, but became normal after the serum triglyceride had been reduced by diet. An oral glucose load showed impairment of glucose tolerance. Insulin resistance was suggested by a small decrease in plasma glucose, with a normal increase in serum insulin, after intravenous tolbutamide. Serum triglyceride and pre-f-lipoprotein concentrations increased after oral glucose. Observations in two other children with diabetic glucose tolerance curves suggested that the increase in serum triglyceride after oral glucose was related to the insulin response rather than to the degree of hyperglycaemia.

Full text

PDF
73

Images in this article

75Fig. 2
on p.75
78Fig. 5
on p.78

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AHRENS E. H., Jr, HIRSCH J., OETTE K., FARQUHAR J. W., STEIN Y. Carbohydrate-induced and fat-induced lipemia. Trans Assoc Am Physicians. 1961;74:134–146. [PubMed] [Google Scholar]
  2. BARTLETT G. R. Phosphorus assay in column chromatography. J Biol Chem. 1959 Mar;234(3):466–468. [PubMed] [Google Scholar]
  3. DE LA HUERGA J., YESINICK C., POPPER H. Estimation of total serum lipids by a turbidimetric method. Am J Clin Pathol. 1953 Nov;23(11):1163–1167. doi: 10.1093/ajcp/23.11_ts.1163. [DOI] [PubMed] [Google Scholar]
  4. DOLE V. P., MEINERTZ H. Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem. 1960 Sep;235:2595–2599. [PubMed] [Google Scholar]
  5. Davidson P. C., Albrink M. J. Insulin resistance in hyperglyceridemia. Metabolism. 1965 Oct;14(10):1059–1070. doi: 10.1016/0026-0495(65)90154-x. [DOI] [PubMed] [Google Scholar]
  6. FREEMAN N. K. SIMULTANEOUS DETERMINATION OF TRIGLYCERIDES AND CHOLESTEROL ESTERS IN SERUM BY INFRARED SPECTROPHOTOMETRY. J Lipid Res. 1964 Apr;5:236–241. [PubMed] [Google Scholar]
  7. Fosbrooke A. S., Tamir I. A modified method for the preparation of methyl esters of a mixture of medium-chain and long-chain fatty acids. Application to the determination of serum triglyceride and non-esterified fatty acid composition and concentration by gas-liquid chromatography. Clin Chim Acta. 1968;20(3):517–522. doi: 10.1016/0009-8981(68)90311-2. [DOI] [PubMed] [Google Scholar]
  8. Fredrickson D. S., Levy R. I., Lees R. S. Fat transport in lipoproteins--an integrated approach to mechanisms and disorders. N Engl J Med. 1967 Feb 2;276(5):273–concl. doi: 10.1056/NEJM196702022760507. [DOI] [PubMed] [Google Scholar]
  9. Grant D. B. Fasting serum insulin levels in childhood. Arch Dis Child. 1967 Aug;42(224):375–378. doi: 10.1136/adc.42.224.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KANE J. P., LONGCOPE C., PAVLATOS F. C., GRODSKY G. M. STUDIES OF CARBOHYDRATE METABOLISM IN IDIOPATHIC HYPERTRIGLYCERIDEMIA. Metabolism. 1965 Apr;14:471–486. doi: 10.1016/0026-0495(65)90038-7. [DOI] [PubMed] [Google Scholar]
  11. KNITTLE J. L., AHRENS E. H., Jr CARBOHYDRATE METABOLISM IN TWO FORMS OF HYPERGLYCERIDEMIA. J Clin Invest. 1964 Mar;43:485–495. doi: 10.1172/JCI104934. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. NESTEL P. J. RELATIONSHIP BETWEEN PLASMA TRIGLYCERIDES AND REMOVAL OF CHYLOMICRONS. J Clin Invest. 1964 May;43:943–949. doi: 10.1172/JCI104980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Reaven G. M., Hill D. B., Gross R. C., Farquhar J. W. Kinetics of triglyceride turnover of very low density lipoproteins of human plasma. J Clin Invest. 1965 Nov;44(11):1826–1833. doi: 10.1172/JCI105290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Reaven G. M., Lerner R. L., Stern M. P., Farquhar J. W. Role of insulin in endogenous hypertriglyceridemia. J Clin Invest. 1967 Nov;46(11):1756–1767. doi: 10.1172/JCI105666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rubenstein A. H., Seftel H. C., Miller K., Bersohn I., Wright A. D. Metabolic response to oral glucose in healthy South African white, Indian, and African subjects. Br Med J. 1969 Mar 22;1(5646):748–751. doi: 10.1136/bmj.1.5646.748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SALT H. B., WOLFF O. H. The applications of serum lipoprotein electrophoresis in paediatric practice. Arch Dis Child. 1957 Oct;32(165):404–412. doi: 10.1136/adc.32.165.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. UNGER R. H., MADISON L. L. A new diagnostic procedure for mild diabetes mellitus; evaluation of an intravenous tolbutamide response test. Diabetes. 1958 Nov-Dec;7(6):455–461. doi: 10.2337/diab.7.6.455. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES