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. 1975 Sep;32(3):331–338. doi: 10.1038/bjc.1975.231

In vitro and in vivo evaluation of T and B lymphocyte functions in AKR mice.

D Collavo, G Biasi, A Colombatti, L Chieco-Bianchi
PMCID: PMC2024751  PMID: 786361

Abstract

To investigate whether AKR spontaneous leukaemogenesis is associated with a reduction in functional activity of T lymphocytes, the PHA response of AKR blood cells at different ages up to and including the preleukaemic period was studied. No significant differences were observed among young, adult and preleukaemic donors. In addition, the in vitro and in vivo AKR lymphocyte functions were compared with those of CBA lymphocytes by means of their response to stimulation with T and B lymphocyte selective mitogens (PHA, Con A and LSP respectively), and their response to immunization with thymus dependent (SRBC) or independent (LPS) antigens. We observed in vitro that while the B lymphocytes responded normally to mitogen, an intrinsic hyporeactivity to mitogens characterizes the T lymphocytes. Moreover, AKR mice exhibited a reduced in vivo response to both thymus dependent and independent antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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