Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1975 Sep;32(3):352–354. doi: 10.1038/bjc.1975.234

Augmentation of cytotoxic drug action and X-irradiation by antibodies.

R D Rubens, S Vaughan-Smith, R Dulbecco
PMCID: PMC2024752  PMID: 1233080

Abstract

The effect of an antiserum containing antibodies against cell surface components of PyBHK cells on the action of certain anticancer agents has been studied using a colony formation inhibition assay. The effects of x-rays, chlorambucil, CCNU and possibly ICRF 159 are augmented by the antiserum whereas methotrexate and vinblastine are not.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Davies D. A., Buckham S., Manstone A. J. Protection of mice against syngeneic lymphomata: II. Collaboration between drugs and antibodies. Br J Cancer. 1974 Oct;30(4):305–311. doi: 10.1038/bjc.1974.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ghose T., Cerini M. Radiosensitization of Ehrlich ascites tumour cells by a specific antibody. Nature. 1969 Jun 7;222(5197):993–994. doi: 10.1038/222993a0. [DOI] [PubMed] [Google Scholar]
  3. Rubens R. D., Dulbecco R. Augmentation of cytotoxic drug action by antibodies directed at cell surface. Nature. 1974 Mar 1;248(5443):81–82. doi: 10.1038/248081a0. [DOI] [PubMed] [Google Scholar]
  4. Rubens R. D. Short review. Prospects for cancer immunochemotherapy. Cancer Treat Rev. 1974 Dec;1(4):305–312. doi: 10.1016/s0305-7372(74)80021-6. [DOI] [PubMed] [Google Scholar]
  5. Stephens T. C., Creighton A. M. Proceedings: Mechanism of action studies with IRCF 159: effects on the growth and morphology of BHK-21S cells. Br J Cancer. 1974 Jan;29(1):99–100. doi: 10.1038/bjc.1974.39. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES