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. 1975 Oct;32(4):502–508. doi: 10.1038/bjc.1975.252

Heparin, dextran 1000 and metastasis formation after I.V. tumour cell injection in dextran non-sensitive rats.

L Ivarsson, C M Rudenstam
PMCID: PMC2024767  PMID: 1212413

Abstract

The present study of the effect of heparin and dextran 1000 on the metastasis formation after i.v. tumour cell injection in dextran non-sensitive rats using a syngeneic 20-methylcholanthrene induced fibrosarcoma showed that heparin treatment decreased with formation of pulmonary metastases in animals both untreated and treated with dextran 1000. Treatment with dextran 1000 increased the formation of pulmonary metastases in animals both untreated and treated with heparin and the effect of dextran 1000 was thus not affected by heparin treatment. Heparin did not have any direct action on the tumour cells, which influenced metastasis formation. The data suggest that heparin acts as an anticoagulant with decreased microthrombus formation around lodged cells and that dextrax 1000 stimulates metastasis formation primarily by mechanisms other than intravascular coagulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AGOSTINO D., CLIFFTON E. E. TRAUMA AS A CAUSE OF LOCALIZATION OF BLOOD-BORNE METASTASES: PREVENTIVE EFFECT OF HEPARIN AND FIBRINOLYSIN. Ann Surg. 1965 Jan;161:97–102. doi: 10.1097/00000658-196501000-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. AMBROSE E. J., EASTY D. M., JONES P. C. Specific reactions of polyelectrolytes with the surfaces of normal and tumour cells. Br J Cancer. 1958 Sep;12(3):439–447. doi: 10.1038/bjc.1958.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boeryd B. Action of heparin and plasminogen inhibitor (EACA) on metastatic tumour spread in an isologous system. Acta Pathol Microbiol Scand. 1965;65(3):395–404. doi: 10.1111/apm.1965.65.3.395. [DOI] [PubMed] [Google Scholar]
  4. Boeryd B. Effect of heparin and plasminogen inhibitor (EACA) in brief and prolonged treatment on intravenously injected tumour cells. Acta Pathol Microbiol Scand. 1966;68(3):347–354. doi: 10.1111/apm.1966.68.3.347. [DOI] [PubMed] [Google Scholar]
  5. Boeryd B. Effect of heparin and plasminogen inhibitor (EACA) on intravenously injected ascites tumour cells. Acta Pathol Microbiol Scand. 1966;68(4):547–552. doi: 10.1111/apm.1966.68.4.547. [DOI] [PubMed] [Google Scholar]
  6. Boeryd B., Ganelius T., Lundin P., Mellgren J. Counting and sizing of tumor metastases in experimental oncology. Int J Cancer. 1966 Sep 15;1(5):497–502. doi: 10.1002/ijc.2910010509. [DOI] [PubMed] [Google Scholar]
  7. CLIFFTON E. E., AGOSTINO D. Factors affecting the development of metastatic cancer. Effect of alterations in clottin mechanism. Cancer. 1962 Mar-Apr;15:276–283. doi: 10.1002/1097-0142(196203/04)15:2<276::aid-cncr2820150211>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  8. CLIFFTON E. E., AGOSTINO D. THE EFFECTS OF FIBRIN FORMATION AND ALTERATIONS IN THE CLOTTING MECHANISM ON THE DEVELOPMENT OF METASTASES. Vasc Dis. 1965 Jan;2:43–52. [PubMed] [Google Scholar]
  9. FISHER B., FISHER E. R. Experimental studies of factors influencing hepatic metastases. III. Effect of surgical trauma with special reference to liver injury. Ann Surg. 1959 Oct;150:731–744. doi: 10.1097/00000658-195910000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hagmar B., Boeryd B. Distribution of intravenously induced metastases in heparin- and coumarin-treated mice. Pathol Eur. 1969;4(2):103–111. [PubMed] [Google Scholar]
  11. Hagmar B., Norrby K. Evidence for effects of heparin on cell surfaces influencing experimental metastases. Int J Cancer. 1970 Jan 15;5(1):72–84. doi: 10.1002/ijc.2910050110. [DOI] [PubMed] [Google Scholar]
  12. Jones D. S., Wallace A. C., Fraser E. E. Sequence of events in experimental metastases of Walker 256 tumor: light, immunofluorescent, and electron microscopic observations. J Natl Cancer Inst. 1971 Mar;46(3):493–504. [PubMed] [Google Scholar]
  13. KOIKE A. MECHANISM OF BLOOD-BORNE METASTASES. I. SOME FACTORS AFFECTING LODGMENT AND GROWTH OF TUMOR CELLS IN THE LUNGS. Cancer. 1964 Apr;17:450–460. doi: 10.1002/1097-0142(196404)17:4<450::aid-cncr2820170406>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  14. LAWRENCE E. A., MOORE D. B., BERNSTEIN G. I. The ability of the pulmonary vascular system to influence the spread of tumor emboli. J Thorac Surg. 1953 Sep;26(3):233–240. [PubMed] [Google Scholar]
  15. ROBINSON K. P., HOPPE E. The development of blood-borne metastases. Effect of local trauma and ischemia. Arch Surg. 1962 Nov;85:720–724. doi: 10.1001/archsurg.1962.01310050022005. [DOI] [PubMed] [Google Scholar]
  16. Suemasu K., Ishikawa S. Inhibitive effect of heparin and dextran sulfate on experimental pulmonary metastases. Gan. 1970 Apr;61(2):125–130. [PubMed] [Google Scholar]
  17. Taylor H. E., Culling C. F. Cytopathic effect of sensitized spleen cells on fibroblasts. The protective effect of heparin. Lab Invest. 1966 Dec;15(12):1960–1965. [PubMed] [Google Scholar]
  18. WOOD S., Jr Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber. AMA Arch Pathol. 1958 Oct;66(4):550–568. [PubMed] [Google Scholar]
  19. el Rifi K., Bacon B., Mehigan J., Hoppe E., Cole W. H. Increased incidence of pulmonary metastases after celiotomy: counteraction by heparin. Arch Surg. 1965 Oct;91(4):625–629. doi: 10.1001/archsurg.1965.01320160079018. [DOI] [PubMed] [Google Scholar]

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