Abstract
N-dibutyl-nitrosamine induced pulmonary adenocarcinoma in European hamsters were studied electron microscopically. The tumours were composed of light and dark cells, which, due to their lamellar bodies, resembled alveolar epithelial cells Type II. As cells containing lamellar bodies also occasionally occurred with the epithelial lining of tumour associated peripheral bronchi, a possible bronchiolar origin of the neoplasms is discussed.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Althoff J., Mohr U., Page N., Reznik G. Carcinogenic effect of dibutylnitrosamine in European hamsters (Cricetus cricetus). J Natl Cancer Inst. 1974 Sep;53(3):795–800. doi: 10.1093/jnci/53.3.795. [DOI] [PubMed] [Google Scholar]
- CAMPICHE M. A., GAUTIER A., HERNANDEZ E. I., REYMOND A. AN ELECTRON MICROSCOPE STUDY OF THE FETAL DEVELOPMENT OF HUMAN LUNG. Pediatrics. 1963 Dec;32:976–994. [PubMed] [Google Scholar]
- Coalson J. J., Mohr J. A., Pirtle J. K., Dee A. L., Rhoades E. R. Electron microscopy of neoplasms in the lung with special emphasis on the alveolar cell carcinoma. Am Rev Respir Dis. 1970 Feb;101(2):181–197. doi: 10.1164/arrd.1970.101.2.181. [DOI] [PubMed] [Google Scholar]
- Hage E. The morphological development of the pulmonary epithelium of human foetuses studied by light- and electron microscopy. Z Anat Entwicklungsgesch. 1973 Aug 30;140(3):271–279. doi: 10.1007/BF00525057. [DOI] [PubMed] [Google Scholar]
- O'Hare K. H., Sheridan M. N. Electron microscopic observations on the morphogenesis of the albino rat lung, with special reference to pulmonary epithelial cells. Am J Anat. 1970 Feb;127(2):181–205. doi: 10.1002/aja.1001270205. [DOI] [PubMed] [Google Scholar]
- Pattle R. E., Gandy G., Schock C., Creasey J. M. Lung inclusion bodies: different ultrastructure in simian and non-simian mammals. Experientia. 1974 Jul 15;30(7):797–798. doi: 10.1007/BF01924192. [DOI] [PubMed] [Google Scholar]
- Pluot M., Hopfner C., Adnet J. J., Caulet T. Aspect ultrastructural des lesions induites au niveau du poumon de souris par le N-nitroso-N-methylurethane. Essai d'interprétation des inclusions cristallines cellulaires. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1972;77(4):279–291. doi: 10.1007/BF00283971. [DOI] [PubMed] [Google Scholar]
- Straks W., Feron V. J. Ultrastructure of pulmonary adenomas induced by intratracheal instillation of diethylnitrosamine in Syrian golden hamsters. Eur J Cancer. 1973 May;9(5):359–362. doi: 10.1016/0014-2964(73)90051-0. [DOI] [PubMed] [Google Scholar]