Abstract
The effect of methotrexate on solid rodent tumours has been investigated using the spontaneous mammary adenocarcinoma of the female C3H/Bts mouse. As these tumours exhibit a wide range of volume doubling times, calculations of tumour response to methotrexate must be related to doubling time. When methotrexate is injected into the tumour a dose-dependent tumour response is obtained. Systemic citrovorum "rescue" prevents methotrexate lethalities but reduces tumour response by a factor of 2. Methotrexate-treated tumours have an increased volume doubling time post treatment.
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Selected References
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- BERENBAUM M. C., BROWN I. N. THE EFFECT OF DELAYED ADMINISTRATION OF FOLINIC ACID ON IMMUNOLOGICAL INHIBITION BY METHOTREXATE. Immunology. 1965 Mar;8:251–259. [PMC free article] [PubMed] [Google Scholar]
- Cheshire P. J., Lindop P. J. The influence of intracellular recovery and hypoxic cells on the radiation response of mammary tumours and skin in C3H mice. Br J Radiol. 1969 Mar;42(495):215–223. doi: 10.1259/0007-1285-42-495-215. [DOI] [PubMed] [Google Scholar]
- DELMONTE L., JUKES T. H. Folic acid antagonists in cancer chemotherapy. Pharmacol Rev. 1962 Mar;14:91–135. [PubMed] [Google Scholar]
- Eder M., Rostock H., Vogel G. Die Wirkung von Folsäureantagonisten (Methotrexat) auf die Regeneration der Darmschleimhaut. Virchows Arch Pathol Anat Physiol Klin Med. 1966 Jun 21;341(2):164–176. [PubMed] [Google Scholar]
- Humphreys S. R., Mantel N., Goldin A. Chemotherapy and surgery of spontaneous tumors of mice. Eur J Cancer. 1966 Feb;2(1):1–7. doi: 10.1016/0014-2964(66)90083-1. [DOI] [PubMed] [Google Scholar]
- SCHOLLER J., PHILIPS F. S., BITTNER J. J. Assays with first- or second-generation transplants of spontaneous mammary adenocarcinomas of mice. Cancer Res. 1955;Suppl. 3:32–37. [PubMed] [Google Scholar]