Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1976 Feb;33(2):181–186. doi: 10.1038/bjc.1976.23

Immunogenicity of a rat leukaemia of spontaneous origin (SAL).

A B Wrathmell, P Alexander
PMCID: PMC2024946  PMID: 769814

Abstract

The SAL rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the RES or by immunization with SAL cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. However, immunization with SAL cells exposed to low doses of mitomycin-C slowed the growth of the challenge inoculum. Cells treated with high doses of mitomycin-C did not immunize. The results are interpreted in terms of rapid shedding of a tumour-specific antigen from the membrane of SAL cells.

Full text

PDF
181

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander P. Proceedings: Escape from immune destruction by the host through shedding of surface antigens: is this a characteristic shared by malignant and embryonic cells? Cancer Res. 1974 Aug;34(8):2077–2082. [PubMed] [Google Scholar]
  2. Apffel C. A., Arnason B. G., Peters J. H. Induction of tumour immunity with tumour cells treated with iodoacetate. Nature. 1966 Feb 12;209(5024):694–696. doi: 10.1038/209694a0. [DOI] [PubMed] [Google Scholar]
  3. Baldwin R. W. Tumour-specific immunity against spontaneous rat tumours. Int J Cancer. 1966 May 15;1(3):257–264. doi: 10.1002/ijc.2910010305. [DOI] [PubMed] [Google Scholar]
  4. Currie G. A., Alexander P. Spontaneous shedding of TSTA by viable sarcoma cells: its possible role in facilitating metastatic spread. Br J Cancer. 1974 Jan;29(1):72–75. doi: 10.1038/bjc.1974.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gross L. Specific, active, intradermal immunization against leukemia in guinea pigs. Acta Haematol. 1970;44(1):1–10. doi: 10.1159/000208656. [DOI] [PubMed] [Google Scholar]
  6. ISHIDATE M., HASHIMOTO Y., ODASHIMA S., SUDO H. STUDIES ON ACQUIRED TRANSPLANTATION RESISTANCE. I. PRETREATMENT OF DONRYU RAT WITH ATTENUATED YOSHIDA SARCOMA CELLS. Gan. 1965 Feb;56:13–21. [PubMed] [Google Scholar]
  7. PREHN R. T., MAIN J. M. Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst. 1957 Jun;18(6):769–778. [PubMed] [Google Scholar]
  8. Proctor J. W., Rudenstam C. M., Alexander P. A preliminary investigation into the role of immunity in modifying the blood- borne spread of chemically induced rat sarcomas. J Natl Cancer Inst. 1974 Dec;53(6):1671–1676. [PubMed] [Google Scholar]
  9. SHATKIN A. J., REICH E., FRANKLIN R. M., TATUM E. L. Effect of mitomycin C on mammalian cells in culture. Biochim Biophys Acta. 1962 Mar 5;55:277–289. doi: 10.1016/0006-3002(62)90783-7. [DOI] [PubMed] [Google Scholar]
  10. SZYBALSKI W., IYER V. N. CROSSLINKING OF DNA BY ENZYMATICALLY OR CHEMICALLY ACTIVATED MITOMYCINS AND PORFIROMYCINS, BIFUNCTIONALLY "ALKYLATING" ANTIBIOTICS. Fed Proc. 1964 Sep-Oct;23:946–957. [PubMed] [Google Scholar]
  11. Wang M., Halliday W. J. Immune responses of mice to iodoacetate-treated Ehrlich ascites tumour cells. Br J Cancer. 1967 Jun;21(2):346–352. doi: 10.1038/bjc.1967.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wrathmell A. B. The growth patterns of two transplantable acute leukaemias of spontaneous origin in rats. Br J Cancer. 1976 Feb;33(2):172–180. doi: 10.1038/bjc.1976.22. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES