Abstract
Thirty-six lung adenomata induced in mice by urethane followed or not by cortisone, all had an adenomatous morphology at first s.c. transplant in syngeneic hosts. Seventeen of them acquired a sarcomatous structure within a few s.c. transplant generations whilst the other 19 remained adenomatous for as long as tested, i.e. at least 10 transplant generations. The change of morphology was not dependent on s.c. growth, since tumours also transformed when allowed to grow in the lung, and was not correlated to the capacity of a tumour for growth or metastasis. The 2 types of tumours were antigenically different, since only tumours that after few transplants changed their morphology were found at the first s.c. transplant to possess tumour-associated membrane antigens as revealed by an in vitro test. In addition, only the tumours which acquired a sarcomatous morphology were found gs-positive. The majority of antigenic primary tumours arose in mice belonging to the groups of treatment which induced the strongest immunodepression. It is suggested that a predisposition to sarcoma progression is related to an immunological control, at the time of adenoma induction, of an oncornavirus, responsible for the superimposed sarcomatous change.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boyse E. A., Stockert E., Old L. J. Modification of the antigenic structure of the cell membrane by thymus-leukemia (TL) antibody. Proc Natl Acad Sci U S A. 1967 Sep;58(3):954–957. doi: 10.1073/pnas.58.3.954. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Colnaghi M. I., Ménard S., Porta G. D. Demonstration of cellular immunity against urethan-induced lung adenomas of mice. J Natl Cancer Inst. 1971 Dec;47(6):1325–1331. [PubMed] [Google Scholar]
- Ioachim H. L., Dorsett B., Sabbath M., Keller S. Loss and recovery of phenotypic expression of Gross leukaemia virus. Nat New Biol. 1972 Jun 14;237(76):215–218. doi: 10.1038/newbio237215b0. [DOI] [PubMed] [Google Scholar]
- Kimura I., Miyake T., Ishimoto A., Ito Y. Intracisternal A-type and C-type particles observed in pulmonary tumors in mice. Gan. 1972 Oct;63(5):563–573. [PubMed] [Google Scholar]