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. 1976 Mar;33(3):320–328. doi: 10.1038/bjc.1976.46

The sensitivity to cytotoxic agents of the EMT6 tumor in vivo. Comparative response of lung nodules in rapid expotential growth and of the solid flank tumour.

P R Twentyman, N M Bleehen
PMCID: PMC2024992  PMID: 57788

Abstract

Experiments are described in which dose-response data have been obtained for EMT6 mouse tumour cells growing in vivo and exposed to various cytotoxic agents. A comparison has been made of the response of solid tumours in the flank and of rapidly growing lung nodules. The results are discussed with regard to their cell kinetic implications and compared with our results for the chemosensitivity of EMT6 cells in exponential and plateau phase growth in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barranco S. C., Novak J. K., Humphrey R. M. Studies on recovery from chemically induced damage in mammalian cells. Cancer Res. 1975 May;35(5):1194–1204. [PubMed] [Google Scholar]
  2. Barranco S. C., Novak J. K. Survival responses of dividing and nondividing mammalian cells after treatment with hydroxyurea, arabinosylcytosine, or adriamycin. Cancer Res. 1974 Jul;34(7):1616–1618. [PubMed] [Google Scholar]
  3. Blackett N. M., Adams K. Cell proliferation and the action of cytotoxic agents on haemopoietic tissue. Br J Haematol. 1972 Dec;23(6):751–758. doi: 10.1111/j.1365-2141.1972.tb03489.x. [DOI] [PubMed] [Google Scholar]
  4. Conzelman G. M., Jr, Springer K. The influence of the anatomic locationof a tumor on its susceptibility to chemotherapy. Cancer Chemother Rep. 1969 Apr;53(2):105–113. [PubMed] [Google Scholar]
  5. Hagemann R. F., Schenken L. L., Lesher S. Tumor chemotherapy: efficacy dependent on mode of growth. J Natl Cancer Inst. 1973 Feb;50(2):467–474. doi: 10.1093/jnci/50.2.467. [DOI] [PubMed] [Google Scholar]
  6. Hahn G. M., Braun J., Har-Kedar I. Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation. Proc Natl Acad Sci U S A. 1975 Mar;72(3):937–940. doi: 10.1073/pnas.72.3.937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hahn G. M., Gordon L. F., Kurkjian S. D. Responses of cycling and noncycling cells to 1,3-bis(2-chloroethyl)-1-nitrosourea and to bleomycin. Cancer Res. 1974 Sep;34(9):2373–2377. [PubMed] [Google Scholar]
  8. Hahn G. M., Little J. B. Plateau-phase cultures of mammalian cells: an in vitro model for human cancer. Curr Top Radiat Res Q. 1972 Jul;8(1):39–43. [PubMed] [Google Scholar]
  9. Hill R. P., Stanley J. A. The response of hypoxic B16 melanoma cells to in vivo treatment with chemotherapeutic agents. Cancer Res. 1975 May;35(5):1147–1153. [PubMed] [Google Scholar]
  10. Lin H. Differential lethal effect of cytotoxic agents on proliferating and nonproliferating lymphoid cells. Cancer Res. 1973 Jul;33(7):1716–1720. [PubMed] [Google Scholar]
  11. Ray G. R., Hahn G. M., Bagshaw M. A., Kurkjian S. Cell survival and repair of plateau-phase cultures after chemotherapy--relevance to tumor therapy and to the in vitro screening of new agents. Cancer Chemother Rep. 1973 Nov-Dec;57(4):473–475. [PubMed] [Google Scholar]
  12. Rockwell S. C., Kallman R. F., Fajardo L. F. Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative. J Natl Cancer Inst. 1972 Sep;49(3):735–749. [PubMed] [Google Scholar]
  13. Rosenblum M. L., Wheeler K. T., Wilson C. B., Barker M., Knebel K. D. In vitro evaluation of in vivo brain tumor chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 1975 Jun;35(6):1387–1391. [PubMed] [Google Scholar]
  14. Steel G. G., Adams K. Stem-cell survival and tumor control in the Lewis lung carcinoma. Cancer Res. 1975 Jun;35(6):1530–1535. [PubMed] [Google Scholar]
  15. Twentyman P. R., Bleehen N. M. Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line. Br J Cancer. 1975 Apr;31(4):417–423. doi: 10.1038/bjc.1975.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Twentyman P. R., Bleehen N. M. Studies of "potentially lethal damage" in EMT6 mouse tumour cells treated with bleomycin either in vitro or in vivo. Br J Cancer. 1975 Oct;32(4):491–501. doi: 10.1038/bjc.1975.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Twentyman P. R., Bleehen N. M. The sensitivity to bleomycin of a solid mouse tumour at different stages of growth. Br J Cancer. 1974 Nov;30(5):469–472. doi: 10.1038/bjc.1974.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Twentyman P. R., Bleehen N. M. The sensitivity to bleomycin of spleen colony forming units in the mouse. Br J Cancer. 1973 Jul;28(1):66–70. doi: 10.1038/bjc.1973.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wharam M. D., Phillips T. L., Kane L., Utley J. F. Response of a murine solid tumor to in vivo combined chemotherapy and irradiation. Radiology. 1973 Nov;109(2):451–455. doi: 10.1148/109.2.451. [DOI] [PubMed] [Google Scholar]
  20. van Putten L. M. Are cell kinetic data relevant for the design of tumour chemotherapy schedules? Cell Tissue Kinet. 1974 Sep;7(5):493–504. doi: 10.1111/j.1365-2184.1974.tb00432.x. [DOI] [PubMed] [Google Scholar]

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