Abstract
Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but the differences between the two treatments did not achieve formal significance. The combination was logistically easier to manage and produced less toxicity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Atkins H., Bulbrook R. D., Falconer M. A., Hayward J. L., MacLean K. S., Schurr P. H. Ten years' experience of sterioid assays in the management of breast cancer. A review. Lancet. 1968 Dec 14;2(7581):1255–1260. doi: 10.1016/s0140-6736(68)91757-1. [DOI] [PubMed] [Google Scholar]
- Baker L. H., Vaughn C. B., al-Sarraf M., Reed M. L., Vaitkevicius V. K. Proceedings: Evaluation of combination vs. sequential cytotoxic chemotherapy in the treatment of advanced breast cancer. Cancer. 1974 Feb;33(2):513–518. doi: 10.1002/1097-0142(197402)33:2<513::aid-cncr2820330228>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
- Blum R. H., Carter S. K. Adriamycin. A new anticancer drug with significant clinical activity. Ann Intern Med. 1974 Feb;80(2):249–259. doi: 10.7326/0003-4819-80-2-249. [DOI] [PubMed] [Google Scholar]
- Brambilla C., De Lena M., Bonadonna G. Combination chemotherapy with adriamycin (NSC-123127) in metastatic mammary carcinoma. Cancer Chemother Rep. 1974 Mar-Apr;58(2):251–253. [PubMed] [Google Scholar]
- Canellos G. P., Devita V. T., Gold G. L., Chabner B. A., Schein P. S., Young R. C. Cyclical combination chemotherapy for advanced breast carcinoma. Br Med J. 1974 Feb 9;1(5901):218–220. doi: 10.1136/bmj.1.5901.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carter S. K. Single and combination nonhormonal chemotherapy in breast cancer. Cancer. 1972 Dec;30(6):1543–1555. doi: 10.1002/1097-0142(197212)30:6<1543::aid-cncr2820300621>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
- Devita V. T., Jr, Serpick A. A., Carbone P. P. Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med. 1970 Dec;73(6):881–895. doi: 10.7326/0003-4819-73-6-881. [DOI] [PubMed] [Google Scholar]
- Fisher B., Carbone P., Economou S. G., Frelick R., Glass A., Lerner H., Redmond C., Zelen M., Band P., Katrych D. L. 1-Phenylalanine mustard (L-PAM) in the management of primary breast cancer. A report of early findings. N Engl J Med. 1975 Jan 16;292(3):117–122. doi: 10.1056/NEJM197501162920301. [DOI] [PubMed] [Google Scholar]
- Frei E., 3rd Combination cancer therapy: Presidential address. Cancer Res. 1972 Dec;32(12):2593–2607. [PubMed] [Google Scholar]