Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1976 Aug;34(2):207–209. doi: 10.1038/bjc.1976.145

Induction of tumours in intact and partially hepatectomized rats with ethyl methanesulphonate.

V M Craddock, J V Frei
PMCID: PMC2025154  PMID: 183802

Full text

PDF
207

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Craddock V. M., Frei J. V. Induction of liver cell adenomata in the rat by a single treatment with N-methyl-N-nitrosourea given at various times after partial hepatectomy. Br J Cancer. 1974 Dec;30(6):503–511. doi: 10.1038/bjc.1974.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Craddock V. M. Induction of liver tumours in rats by a single treatment with nitroso compounds given after partial hepatectomy. Nature. 1973 Oct 19;245(5425):386–389. doi: 10.1038/245386a0. [DOI] [PubMed] [Google Scholar]
  3. Frei J. V., Lawley P. D. Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N' -nitro-N-nitrosoguanidine: lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at 0-6 of guanine. Chem Biol Interact. 1976 Jun;13(3-4):215–222. doi: 10.1016/0009-2797(76)90075-2. [DOI] [PubMed] [Google Scholar]
  4. Frei J. V. Tumour induction by low molecular weight alkylating agents. Chem Biol Interact. 1971 Apr;3(2):117–121. doi: 10.1016/0009-2797(71)90091-3. [DOI] [PubMed] [Google Scholar]
  5. Goth R., Rajewsky M. F. Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A. 1974 Mar;71(3):639–643. doi: 10.1073/pnas.71.3.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Haas H., Hilfrich J., Mohr U. Induction of heart tumours in Wistar rats after a single application of ethylmethanesulphonate and dimethylnitrosamine. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):225–228. doi: 10.1007/BF00305022. [DOI] [PubMed] [Google Scholar]
  7. Hrushesky W., Sampson D., Murphy G. P. Carcinogenicity of ethylmethanesulfonate. J Natl Cancer Inst. 1972 Oct;49(4):1077–1083. [PubMed] [Google Scholar]
  8. Kleihues P., Margison G. P. Carcinogenicity of N-methyl-N-nitrosourea: possible role of excision repair of O6-methylguanine from DNA. J Natl Cancer Inst. 1974 Dec;53(6):1839–1841. [PubMed] [Google Scholar]
  9. Lawley P. D., Orr D. J., Jarman M. Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines. Biochem J. 1975 Jan;145(1):73–84. doi: 10.1042/bj1450073. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Loveless A. Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides. Nature. 1969 Jul 12;223(5202):206–207. doi: 10.1038/223206a0. [DOI] [PubMed] [Google Scholar]
  11. Montesano R., Mohr U., Magee P. N., Hilfrich J., Haas H. Additive effect in the induction of kidney tumours in rats treated with dimethylnitrosamine and ethylmethanesulphonate. Br J Cancer. 1974 Jan;29(1):50–58. doi: 10.1038/bjc.1974.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nicoll J. W., Swann P. F., Pegg A. E. Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA. Nature. 1975 Mar 20;254(5497):261–262. doi: 10.1038/254261a0. [DOI] [PubMed] [Google Scholar]
  13. Pound A. W. Carcinogenesis and cell proliferation. N Z Med J. 1968 Jan;67(426 Suppl):88–99. [PubMed] [Google Scholar]
  14. Shooter K. V., Howse R., Shah S. A., Lawley P. D. The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17. Biochem J. 1974 Feb;137(2):303–312. doi: 10.1042/bj1370303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sun L., Singer B. The specificity of different classes of ethylating agents toward various sites of HeLa cell DNA in vitro and in vivo. Biochemistry. 1975 Apr 22;14(8):1795–1802. doi: 10.1021/bi00679a036. [DOI] [PubMed] [Google Scholar]
  16. Swann P. F., Magee P. N. Induction of rat kidney tumours by ethyl methanesulphonate and nervous tissue tumours by methyl methanesulphonate and ethyl methanesulphonate. Nature. 1969 Aug 30;223(5209):947–949. doi: 10.1038/223947a0. [DOI] [PubMed] [Google Scholar]
  17. Swann P. F., Magee P. N. Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate. Biochem J. 1971 Dec;125(3):841–847. doi: 10.1042/bj1250841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. TSinger B., Fraenkel-Conrat H. The specificity of different classes of ethylating agents toward various sites in RNA. Biochemistry. 1975 Feb 25;14(4):772–782. doi: 10.1021/bi00675a020. [DOI] [PubMed] [Google Scholar]
  19. Walters M. A., Roe F. J., Mitchley B. C., Walsh A. Further tests for carcinogenesis using newborn mice: 2-naphthylamine, 2-naphthylhydroxylamine, 2-acetylaminofluorene and ethyl methane sulphonate. Br J Cancer. 1967 Jun;21(2):367–372. doi: 10.1038/bjc.1967.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Williams P. D., Hrushesky W., Gaeta J. F., Murphy G. P. Influence of hormone therapy on rats treated with the carcinogen ethylmethanesulphonate. Res Commun Chem Pathol Pharmacol. 1974 Jan;7(1):25–30. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES