Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1976 Aug;34(2):167–173. doi: 10.1038/bjc.1976.139

5-year follow-up of cytotoxic chemotherapy as an adjuvant to surgery in carcinoma of the bronchus.

H Stott, R J Stephens, W Fox, D C Roy
PMCID: PMC2025161  PMID: 786362

Abstract

This report gives the 5-year findings of a double-blind study of long-term cytotoxic chemotherapy as an adjuvant to surgery in patients receiving busulphan or cyclophosphamide for carcinoma of the bronchus compared with a group receiving a placebo. Of 243 patients initially allocated busulphan, 234 cyclophosphamide and 249 placebo, 28%, 27% and 34% respectively were alive at 5 years. There were significant associations between mortality from bronchial carcinoma and histological involvement of the resected intrathoracic nodes and the histology of the tumour. Haematological toxicity, especially thrombocytopenia, was frequent and severe in the busulphan series, and low platelet counts continued long after chemotherapy was stopped.

Full text

PDF
167

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alberto P. Remission rates, survival, and prognostic factors in combination chemotherapy for bronchogenic carcinoma. Cancer Chemother Rep 3. 1973 Mar;4(2):199–206. [PubMed] [Google Scholar]
  2. BELCHER J. R., ANDERSON R. SURGICAL TREATMENT OF CARCINOMA OF THE BRONCHUS. Br Med J. 1965 Apr 10;1(5440):948–954. doi: 10.1136/bmj.1.5440.948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bergsagel D. E. An assessment of massive-dose chemotherapy of malignant disease. Can Med Assoc J. 1971 Jan 9;104(1):31–36. [PMC free article] [PubMed] [Google Scholar]
  4. Bignall J. R., Martin M., Smithers D. W. Survival in 6086 cases of bronchial carcinoma. Lancet. 1967 May 20;1(7499):1067–1070. doi: 10.1016/s0140-6736(67)92647-5. [DOI] [PubMed] [Google Scholar]
  5. Brunner K. W., Marthaler T., Müller W. Effects of long-term adjuvant chemotherapy with cyclophosphamide (NSC-26271) for radically resected bronchogenic carcinoma. Cancer Chemother Rep 3. 1973 Mar;4(2):125–132. [PubMed] [Google Scholar]
  6. Dolton E. G. Combined surgery and chemotherapy for carcinoma of bronchus. Lancet. 1970 Jan 3;1(7636):40–41. doi: 10.1016/s0140-6736(70)90554-4. [DOI] [PubMed] [Google Scholar]
  7. Green R. A., Humphrey E., Close H., Patno M. E. Alkylating agents in bronchogenic carcinoma. Am J Med. 1969 Apr;46(4):516–525. doi: 10.1016/0002-9343(69)90071-0. [DOI] [PubMed] [Google Scholar]
  8. Higgins G. A., Beebe G. W. Bronchogenic carcinoma. Factors in survival. Arch Surg. 1967 Apr;94(4):539–549. doi: 10.1001/archsurg.1967.01330100103016. [DOI] [PubMed] [Google Scholar]
  9. Higgins G. A., Jr Use of chemotherapy as an adjuvant to surgery for bronchogenic carcinoma. Cancer. 1972 Nov;30(5):1383–1387. doi: 10.1002/1097-0142(197211)30:5<1383::aid-cncr2820300536>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  10. Higgins G. A., Lawton R., Heilbrunn A., Keehn R. J. Prognostic factors in lung cancer. Surgical aspects. Ann Thorac Surg. 1969 May;7(5):472–480. doi: 10.1016/s0003-4975(10)66211-x. [DOI] [PubMed] [Google Scholar]
  11. Karrar K. Importance of dose schedules in adjuvant chemotherapy. Cancer Chemother Rep. 1972 Feb;56(1):35–45. [PubMed] [Google Scholar]
  12. Karrer K., Pridun N., Zwintz E. Chemotherapeutic studies in bronchogenic carcinoma by the Austrian study group. Cancer Chemother Rep 3. 1973 Mar;4(2):207–213. [PubMed] [Google Scholar]
  13. Laing A. H., Berry R. J., Newman C. R., Peto J. Treatment of inoperable carcinoma of bronchus. Lancet. 1975 Dec 13;2(7946):1161–1164. doi: 10.1016/s0140-6736(75)92654-9. [DOI] [PubMed] [Google Scholar]
  14. Lung cancer: perspectives and prospects. Ann Intern Med. 1970 Dec;73(6):1003–1024. doi: 10.7326/0003-4819-73-6-1003. [DOI] [PubMed] [Google Scholar]
  15. Pool J. L. Survival in lung cancer; effectiveness of surgery. N Y State J Med. 1971 Sep 1;71(17):2045–2049. [PubMed] [Google Scholar]
  16. Stott H., Stephens R., Fox W., Simon G., Roy D. C. An investigation of the chest radiographs in a controlled trial of busulphan, cyclophosphamide, and a placebo after resection for carcinoma of the lung. Thorax. 1976 Jun;31(3):265–270. doi: 10.1136/thx.31.3.265. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES