Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1976 Aug;34(2):162–166. doi: 10.1038/bjc.1976.138

Serum ferritin concentration in untreated Hodgkin's disease.

A Jacobs, A Slater, J A Whittaker, G Canellos, P H Wiernik
PMCID: PMC2025167  PMID: 962993

Abstract

Serum ferritin has been estimated in 125 untreated patients with Hodgkin's disease. Increasing concentrations are found at each advancing stage of the disease and high concentrations are found in patients with systemic symptoms. In all cases this is associated with a low serum Fe concentration and reduced transferrin saturation. There is no relationship between serum ferritin concentration and histological type of disease. The findings are compatible with a non-specific response of the reticuloendothelial system to malignancy, producing a secondary disorder of Fe metabolism.

Full text

PDF
162

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aungst C. W. Ferritin in body fluids. J Lab Clin Med. 1968 Mar;71(3):517–522. [PubMed] [Google Scholar]
  2. Beamish M. R., Jones P. A., Trevett D., Evans I. H., Jacobs A. Iron metabolism in Hodgkin's disease. Br J Cancer. 1972 Dec;26(6):444–452. doi: 10.1038/bjc.1972.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bentley D. P., Williams P. Serum ferritin concentration as an index of storage iron in rheumatoid arthritis. J Clin Pathol. 1974 Oct;27(10):786–788. doi: 10.1136/jcp.27.10.786. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bieber C. P., Bieber M. M. Detection of ferritin as a circulating tumor-associated antigen in Hodgkin's disease. Natl Cancer Inst Monogr. 1973 May;36:147–157. [PubMed] [Google Scholar]
  5. Carbone P. P., Kaplan H. S., Musshoff K., Smithers D. W., Tubiana M. Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res. 1971 Nov;31(11):1860–1861. [PubMed] [Google Scholar]
  6. Cartwright G. E., Lee G. R. The anaemia of chronic disorders. Br J Haematol. 1971 Aug;21(2):147–152. doi: 10.1111/j.1365-2141.1971.tb03424.x. [DOI] [PubMed] [Google Scholar]
  7. Eshhar Z., Order S. E., Katz D. H. Ferritin, a Hodgkin's disease associated antigen. Proc Natl Acad Sci U S A. 1974 Oct;71(10):3956–3960. doi: 10.1073/pnas.71.10.3956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jacobs A., Waters W. E., Campbell H., Barrow A. A random sample from Wales. 3. Serum iron, iron binding capacity and transferrin saturation. Br J Haematol. 1969 Dec;17(6):581–587. doi: 10.1111/j.1365-2141.1969.tb01409.x. [DOI] [PubMed] [Google Scholar]
  9. Jones B. M., Worwood M. An automated immunoradiometric assay for ferritin. J Clin Pathol. 1975 Jul;28(7):540–542. doi: 10.1136/jcp.28.7.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jones P. A., Miller F. M., Worwood M., Jacobs A. Ferritinaemia in leukaemia and Hodgkin's disease. Br J Cancer. 1973 Mar;27(3):212–217. doi: 10.1038/bjc.1973.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lukes R. J., Butler J. J. The pathology and nomenclature of Hodgkin's disease. Cancer Res. 1966 Jun;26(6):1063–1083. [PubMed] [Google Scholar]
  12. Prieto J., Barry M., Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology. 1975 Mar;68(3):525–533. [PubMed] [Google Scholar]
  13. REISSMANN K. R., DIETRICH M. R. On the presence of ferritin in the peripheral blood of patients with hepatocellular disease. J Clin Invest. 1956 Jun;35(6):588–595. doi: 10.1172/JCI103312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rappaport H., Berard C. W., Butler J. J., Dorfman R. F., Lukes R. J., Thomas L. B. Report of the Committee on Histopathological Criteria Contributing to Staging of Hodgkin's Disease. Cancer Res. 1971 Nov;31(11):1864–1865. [PubMed] [Google Scholar]
  15. White G. P., Worwood M., Parry D. H., Jacobs A. Ferritin synthesis in normal and leukaemic leukocytes. Nature. 1974 Aug 16;250(467):584–586. doi: 10.1038/250584a0. [DOI] [PubMed] [Google Scholar]
  16. YOUNG D. S., HICKS J. M. METHOD FOR THE AUTOMATIC DETERMINATION OF SERUM IRON. J Clin Pathol. 1965 Jan;18:98–102. doi: 10.1136/jcp.18.1.98. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES