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. 1976 Nov;34(5):546–549. doi: 10.1038/bjc.1976.209

Plasma hormone levels and the incidence of carcinogen-induced mammary tumours in two strains of rat.

R A Hawkins, D Drewitt, B Freedman, E Killin, D A Jenner, E H Cameron
PMCID: PMC2025204  PMID: 826265

Abstract

The incidence of mammary tumours developing after administration of the carcinogen DMBA (at 50 days of age) has been determined in 2 strains of Sprague-Dawley rat. Untreated animals of each strain were exsanguinated in dioestrus at a time corresponding to the early post-carcinogen stage (at 70 days of age) and the plasma concentrations of prolactin, oestradiol-17B and progesterone were measured by radioimmunoassay. In an inbred strain of rats, tumour-induction rate was 6-4% and plasma prolactin concentration was 2-5 x lower than that found in a random-bred strain with a tumour-induction rate of 41-6%. No difference was found between the 2 strains in the level of either ovarian hormone. It is concluded that the difference between these strains in mammary gland susceptibility to DMBA may be related to plasma prolactin concentration, but it is unlikely to be determined by the ovarian hormones.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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