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. 1976 Oct;34(4):437–443. doi: 10.1038/bjc.1976.189

The effect of isoprenaline on induction of tumours by methyl nitrosourea in the salivary and mammary glands of female wistar rats.

R Parkin, S Neale
PMCID: PMC2025246  PMID: 974007

Abstract

Pretreatment of rats with isoprenaline sulphate (IPR) stimulated DNA synthesis in both salivary and mammary gland tissues. Salivary gland tumours induced by N-methyl-N-nitrosourea (MNU) were observed for the first time in rats, but occurred only in IPR-pretreated animals given MNU during the period of IPR-stimulated DNA synthesis. The cumulative index of MNU-induced mammary tumours and the number of tumours per tumour-bearing rat were increased by IPR-pretreament only if the animals received MNU during the period of IPR-stimulated DNA synthesis.

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Selected References

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  1. BURTON K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J. 1956 Feb;62(2):315–323. doi: 10.1042/bj0620315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barka T. Stimulation of DNA synthesis by isoproterenol in the salivary gland. Exp Cell Res. 1965 Sep;39(2):355–364. doi: 10.1016/0014-4827(65)90040-6. [DOI] [PubMed] [Google Scholar]
  3. Baserga R. Induction of DNA synthesis by a purified chemical compound. Fed Proc. 1970 Jul-Aug;29(4):1443–1446. [PubMed] [Google Scholar]
  4. Bots G. T., Willighagen R. G. Tumours in the mammary gland induced in Lewis rats by intravenous methylnitrosurea. Br J Cancer. 1975 Mar;31(3):372–374. doi: 10.1038/bjc.1975.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Burns E. R., Scheving L. E. Isoproterenol-induced phase shifts in circadian rhythm of mitosis in murine corneal epithelium. J Cell Biol. 1973 Feb;56(2):605–608. doi: 10.1083/jcb.56.2.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Burns E. R., Scheving L. E., Tsai T. H. Circadian rhythm in uptake of tritiated thymidine by kidney, parotid, and duodenum of isoproterenol-treated mice. Science. 1972 Jan 7;175(4017):71–73. doi: 10.1126/science.175.4017.71. [DOI] [PubMed] [Google Scholar]
  7. Cherry C. P., Glücksmann A. The histogenesis of carcinomas and sarcomas induced in the salivary glands of rats. Br J Cancer. 1965 Dec;19(4):787–801. doi: 10.1038/bjc.1965.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Craddock V. M., Frei J. V. Induction of liver cell adenomata in the rat by a single treatment with N-methyl-N-nitrosourea given at various times after partial hepatectomy. Br J Cancer. 1974 Dec;30(6):503–511. doi: 10.1038/bjc.1974.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Druckrey H., Preussmann R., Ivankovic S., Schmähl D. Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Z Krebsforsch. 1967;69(2):103–201. [PubMed] [Google Scholar]
  10. Frei J. V., Harsono T. Increased susceptibility to low doses of a carcinogen of epidermal cells in stimulated DNA synthesis. Cancer Res. 1967 Aug;27(8):1482–1484. [PubMed] [Google Scholar]
  11. GLUCKSMAN A., CHERRY C. P. The induction of adenomas by the irradiation of salivary glands of rats. Radiat Res. 1962 Aug;17:186–202. [PubMed] [Google Scholar]
  12. Glucksman A., Cherry C. P. The effect of sex and of sex and thyroid hormones on the induction of cancers in the salivary glands of rats. Br J Cancer. 1966 Dec;20(4):760–777. doi: 10.1038/bjc.1966.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HARKNESS R. D. Regeneration of liver. Br Med Bull. 1957 May;13(2):87–93. doi: 10.1093/oxfordjournals.bmb.a069601. [DOI] [PubMed] [Google Scholar]
  14. HUGGINS C., GRAND L. C., BRILLANTES F. P. Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression. Nature. 1961 Jan 21;189:204–207. doi: 10.1038/189204a0. [DOI] [PubMed] [Google Scholar]
  15. Hooson J., Grasso P., Gangolli S. D. Injection site tumours and preceding pathological changes in rats treated subcutaneously with surfactants and carcinogens. Br J Cancer. 1973 Mar;27(3):230–244. doi: 10.1038/bjc.1973.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Jabara A. G., Toyne P. H., Fisher R. J. An autoradiographic study of the early effects of 7,12-dimethylbenz(a)anthracene and progesterone on DNA synthesis in rat mammary epithelial cells and subsequent tumour development. Br J Cancer. 1972 Aug;26(4):265–273. doi: 10.1038/bjc.1972.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Jabara A. G., Wilson F. C., Fisher R. J. Effect of early inhibition of DNA synthesis by hydroxyurea on 7,12-dimethylbenz(a)anthracene mammary carcinogenesis in the rat. J Pathol. 1974 Aug;113(4):235–240. doi: 10.1002/path.1711130407. [DOI] [PubMed] [Google Scholar]
  18. Kleihues P. Untersuchungen über die Wirkung des Carcinogens N-Methyl-N-nitrosoharnstoff auf die Nukleinsäure-Synthese in vivo. Verh Dtsch Ges Pathol. 1969;53:554–559. [PubMed] [Google Scholar]
  19. Leaver D. D., Swann P. F., Magee P. N. The induction of tumours in the rat by a single oral dose of N-nitrosomethylurea. Br J Cancer. 1969 Mar;23(1):177–187. doi: 10.1038/bjc.1969.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Magin M. N., O'Connor P. J., Craig A. W., Margison G. P. The effect of hormone induced stress upon the extent of alkylation of rat liver nucleic acids by N-methyl-N-nitrosourea. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Nov 25;84(3):217–222. doi: 10.1007/BF00312243. [DOI] [PubMed] [Google Scholar]
  21. Malamud D., Malt R. A. Stimulation of cell proliferation in mouse kidney by isoproterenol. Lab Invest. 1971 Feb;24(2):140–143. [PubMed] [Google Scholar]
  22. Neale S. Effect of pH and temperature on nitrosamide-induced mutation in Escherichia coli. Mutat Res. 1972 Feb;14(2):155–164. doi: 10.1016/0027-5107(72)90044-9. [DOI] [PubMed] [Google Scholar]
  23. Peto R. Editorial: Guidelines on the analysis of tumour rates and death rates in experimental animals. Br J Cancer. 1974 Feb;29(2):101–105. doi: 10.1038/bjc.1974.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. SCOTT J. F., FRACCASTORO A. P., TAFT E. B. Studies in histochemistry. I. Determination of nucleic acids in microgram amounts of tissue. J Histochem Cytochem. 1956 Jan;4(1):1–10. doi: 10.1177/4.1.1. [DOI] [PubMed] [Google Scholar]
  25. Scheving L. E., Burns E. R., Pauly J. E. Circadian rhythms in mitotic activity and 3 H-thymidine uptake in the duodenum: effect of isoproterenol on the mitotic rhythm. Am J Anat. 1972 Nov;135(3):311–317. doi: 10.1002/aja.1001350302. [DOI] [PubMed] [Google Scholar]
  26. Schmutz J. A., Chaudhry A. P. Incidence of induced tumors in the rat submandibular gland with different doses of 7,12-dimethylbenz-(alpha)-anthracene. J Dent Res. 1969 Nov-Dec;48(6):1316–1316. doi: 10.1177/00220345690480064601. [DOI] [PubMed] [Google Scholar]
  27. Swann P. F. The rate of breakdown of methyl methanesulphonate, dimethyl sulphate and N-methyl-N-nitrosourea in the rat. Biochem J. 1968 Nov;110(1):49–52. doi: 10.1042/bj1100049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Winter W. A. Induction of DNA synthesis by isoproterenol in the rat urinary bladder epithelium. Histochemistry. 1974;41(2):141–143. doi: 10.1007/BF00499129. [DOI] [PubMed] [Google Scholar]

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