Abstract
Canine melanoma has been transplanted to allogeneic neonatal recipients receiving continuous immunosuppression with anti-lymphocyte serum. One spontaneous melanoma was directly transplanted into 8 recipients, 6 of which developed tumours. 5/5 melanoma cell cultures were transplantable, with 19 tumour takes in 31 allogeneic recipients. Serial passage was performed in the case of two melanomas. Tumour development required continuous immunosuppression and the site was dependent upon the route of inoculation and other factors. Transplanted cell cultures were all amelanotic in vitro and in vivo, except in the case of one melanoma which reverted to a melanotic morphology after in vivo growth.
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- ALLAM M. W., LOMBARD L. S., STUBBS E. L., SHIRER J. F. Transplantation of a thyroid carcinoma within the canine species. Cancer Res. 1954 Nov;14(10):734–737. [PubMed] [Google Scholar]
- Fisher B., Fisher E. R. The organ distribution of disseminated 51 Cr-labeled tumor cells. Cancer Res. 1967 Feb;27(2):412–420. [PubMed] [Google Scholar]
- Hagmar B., Norrby K. Influence of cultivation, trypsinization and aggregation on the transplantability of melanoma B16 cells. Int J Cancer. 1973 May;11(3):663–675. doi: 10.1002/ijc.2910110317. [DOI] [PubMed] [Google Scholar]
- KASZA L. ESTABLISHMENT AND CHARACTERIZATION OF CANINE THYROID ADENOCARCINOMA AND CANINE MELANOMA CELL LINES. Am J Vet Res. 1964 Jul;25:1178–1185. [PubMed] [Google Scholar]
- LOMBARD L. S., MOLONEY J. B., RICKARD C. G. TRANSMISSIBLE CANINE MASTOCYTOMA. Ann N Y Acad Sci. 1963 Nov 4;108:1086–1105. doi: 10.1111/j.1749-6632.1963.tb13437.x. [DOI] [PubMed] [Google Scholar]
- Moldovanu G., Moore A. E., Friedman M., Miller D. G. Cellular transmission of lymphosarcoma in dogs. Nature. 1966 Jun 25;210(5043):1342–1343. doi: 10.1038/2101342a0. [DOI] [PubMed] [Google Scholar]
- NIELSEN S. W., COLE C. R. Homologous transplantation of canine neoplasms. Am J Vet Res. 1961 Jul;22:663–672. [PubMed] [Google Scholar]
- Owen L. N., Nielsen S. W. Transplantation of canine lymphosarcoma. Eur J Cancer. 1968 Aug;4(4):391–393. doi: 10.1016/0014-2964(68)90029-7. [DOI] [PubMed] [Google Scholar]
- Owen L. N. Transplantation of canine osteosarcoma. Eur J Cancer. 1969 Dec;5(6):615–620. doi: 10.1016/0014-2964(69)90010-3. [DOI] [PubMed] [Google Scholar]