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. 1976 Oct;34(4):368–373. doi: 10.1038/bjc.1976.179

BCG treatment of malignant pleural effusions in the rat.

M V Pimm, D G Hopper, R W Baldwin
PMCID: PMC2025260  PMID: 184810

Abstract

Intrapleurally injected cells of an ascitic rat tumour produced intrapleural effusions and solid pleural deposits. BCG, or its methanol extraction residue (MER) injected into the pleural space, suppressed tumour development and prolonged survival. Treatment was effective if given a few days before or after tumour injection. In contrast, active specific immunotherapy by repeated s.c. injection of viable or radiation-attenuated tumour cells in admixture with BCG was unsuccessful, and did not improve the response to intrapleural BCG treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin R. W., Pimm M. V. BCG immunotherapy of a rat sarcoma. Br J Cancer. 1973 Oct;28(4):281–287. doi: 10.1038/bjc.1973.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baldwin R. W., Pimm M. V. BCG immunotherapy of pulmonary growths from intravenously transferred rat tumour cells. Br J Cancer. 1973 Jan;27(1):48–54. doi: 10.1038/bjc.1973.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bartlett G. L., Zbar B. Tumor-specific vaccine containing Mycobacterium bovis and tumor cells: safety and efficacy. J Natl Cancer Inst. 1972 Jun;48(6):1709–1726. [PubMed] [Google Scholar]
  4. Bast R. C., Jr, Zbar B., Borsos T., Rapp H. J. BCG and cancer (first of two parts). N Engl J Med. 1974 Jun 20;290(25):1413–1420. doi: 10.1056/NEJM197406202902506. [DOI] [PubMed] [Google Scholar]
  5. Chassoux D., Salomon J. C. Therapeutic effect of intratumoral injection of bcg and other substances in rats and mice. Int J Cancer. 1975 Oct 15;16(4):515–525. doi: 10.1002/ijc.2910160402. [DOI] [PubMed] [Google Scholar]
  6. Edwards F. R., Whitwell F. Use of BCG as an immunostimulant in the surgical treatment of carcinoma of the lung. Thorax. 1974 Nov;29(6):654–658. doi: 10.1136/thx.29.6.654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hopper D. G., Pimm M. V., Baldwin R. W. Methanol extraction residue of BCG in the treatment of transplanted rat tumours. Br J Cancer. 1975 Feb;31(2):176–181. doi: 10.1038/bjc.1975.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Laucius J. F., Bodurtha A. J., Mastrangelo M. J., Creech R. H. Bacillus Calmette-Guerin in the treatment of neoplastic disease. J Reticuloendothel Soc. 1974 Dec;16(6):347–373. [PubMed] [Google Scholar]
  9. McKneally M. F., Maver C., Kausel H. W. Regional immunotherapy of lung cancer with intrapleural B.C.G. Lancet. 1976 Feb 21;1(7956):377–379. doi: 10.1016/s0140-6736(76)90212-9. [DOI] [PubMed] [Google Scholar]
  10. Moore M., Lawrence N., Nisbet N. W. Tumour inhibition mediated by BCG in immunosuppressed rats. Int J Cancer. 1975 Jun 15;15(6):897–911. doi: 10.1002/ijc.2910150605. [DOI] [PubMed] [Google Scholar]
  11. Pimm M. V., Baldwin R. W. BCG immunotherapy of rat tumours in athymic nude mice. Nature. 1975 Mar 6;254(5495):77–78. doi: 10.1038/254077a0. [DOI] [PubMed] [Google Scholar]
  12. Pimm M. V., Baldwin R. W. BCG therapy of pleural and peritoneal growth of transplanted rat tumours. Int J Cancer. 1975 Feb 15;15(2):260–269. doi: 10.1002/ijc.2910150212. [DOI] [PubMed] [Google Scholar]
  13. Pimm M. V., Baldwin R. W. Influence of whole body irradiation on bcg contact suppression of a rat sarcoma and tumour-specific immunity. Br J Cancer. 1976 Aug;34(2):199–202. doi: 10.1038/bjc.1976.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pines A. A 5-year controlled study of B.C.G. and radiotherapy inoperable lung cancer. Lancet. 1976 Feb 21;1(7956):380–381. doi: 10.1016/s0140-6736(76)90213-0. [DOI] [PubMed] [Google Scholar]
  15. Robins R. A. Serum antibody responses to an ascitic variant of rat hepatoma D23. Br J Cancer. 1975 Jul;32(1):21–27. doi: 10.1038/bjc.1975.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WEISS D. W., WELLS A. Q. Vaccination against tuberculosis with nonliving vaccines. 3. Vaccination of guinea pigs with fractions of phenol-killed tubercle bacilli. Am Rev Respir Dis. 1960 Sep;82:339–357. doi: 10.1164/arrd.1960.82.3.339. [DOI] [PubMed] [Google Scholar]
  17. Yamamoto S., Dunn C. J., Capasso F., Deporter D. A., Willoughby D. A. Quantitative studies on cell-mediated immunity in the pleural cavity of guinea-pigs. J Pathol. 1975 Oct;117(2):65–73. doi: 10.1002/path.1711170202. [DOI] [PubMed] [Google Scholar]

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