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. 1977 Feb;35(2):170–178. doi: 10.1038/bjc.1977.24

Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes.

A M Ward, E H Cooper, R Turner, J A Anderson, A M Neville
PMCID: PMC2025326  PMID: 13805

Abstract

The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA and hepatic enzymes during the monitoring of postoperative patients. There is considerable stability in the profile in a given individual in health, Rises of AAT and AGP are associated with metastases. High levels of HPT may suggest involvement of the bowel wall by recurrent cancer. PALB levels tend to reflect the nutritional status. A discriminant function based on the log CEA, AAT and AGP preoperative blood levels can considerably improve on the predictive value attained using CEA levels alone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bacchus H. Serum glycoproteins in cancer. Prog Clin Pathol. 1975;6:111–135. [PubMed] [Google Scholar]
  2. Baxter S. J., Rees B. Simultaneous haptoglobin and haemoglobin typing of blood and bloodstains using gradient polyacrylamide gel electrophoresis. Med Sci Law. 1974 Oct;14(4):231–236. doi: 10.1177/002580247401400402. [DOI] [PubMed] [Google Scholar]
  3. Cook P. J. Genetic aspects of the Pi system. Postgrad Med J. 1974 Jun;50(584):362–364. doi: 10.1136/pgmj.50.584.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooper E. H., Turner R., Geekie A., Neville A. M., Goligher J. C., Graham N. G., Giles G. R., Hall R., Macadam W. A. Alpha-globulins in the surveillance of colorectal cancer. Biomedicine. 1976 Jun;24(3):171–178. [PubMed] [Google Scholar]
  5. Cooper E. H., Turner R., Steele L., Neville A. M., Mackay A. M. The contribution of serum enzymes and carcinoembryonic antigen to the early diagnosis of metastatic colorectal cancer. Br J Cancer. 1975 Jan;31(1):111–117. doi: 10.1038/bjc.1975.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. LAUER J. D., CARLSON H. C., WOLLAEGER E. E. ACCURACY OF ROENTGENOLOGIC EXAMINATION IN DETECTING CARCINOMA OF THE COLON. Dis Colon Rectum. 1965 May-Jun;8:190–197. doi: 10.1007/BF02617088. [DOI] [PubMed] [Google Scholar]
  7. Laurence D. J., Stevens U., Bettelheim R., Darcy D., Leese C., Turberville C., Alexander P., Johns E. W., Neville A. M. Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma. Br Med J. 1972 Sep 9;3(5827):605–609. doi: 10.1136/bmj.3.5827.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Marner I. L., Friborg S., Simonsen E. Disease activity and serum proteins in ulcerative colitis. Immunochemical quantitation. Scand J Gastroenterol. 1975;10(5):537–544. [PubMed] [Google Scholar]
  9. Mueller W. K., Handschumacher R., Wade M. E. Serum haptoglobin in patients with ovarian malignancies. Obstet Gynecol. 1971 Sep;38(3):427–435. [PubMed] [Google Scholar]
  10. Munjal D., Chawla P. L., Lokich J. J., Zamcheck N. Carcinoembryonic antigen and phosphohexose isomerase, gammaglutamyl transpeptidase and lactate dehydorgenase levels in patients with and without liver metastases. Cancer. 1976 Apr;37(4):1800–1807. doi: 10.1002/1097-0142(197604)37:4<1800::aid-cncr2820370426>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  11. Neville A. M., Cooper E. H. Biochemical monitoring of cancer. A review. Ann Clin Biochem. 1976 Jan;13(1):283–305. doi: 10.1177/000456327601300101. [DOI] [PubMed] [Google Scholar]
  12. Ritchie R. F., Alper C. A., Graves J., Pearson N., Larson C. Automated quantitation of proteins in serum and other biologic fluids. Am J Clin Pathol. 1973 Feb;59(2):151–159. doi: 10.1093/ajcp/59.2.151. [DOI] [PubMed] [Google Scholar]
  13. Schwartz M. K. Laboratory aids to diagnosis--enzymes. Cancer. 1976 Jan;37(1 Suppl):542–548. doi: 10.1002/1097-0142(197601)37:1+<542::aid-cncr2820370719>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  14. Vickers M., Jr Serum haptoglobins: a preoperative detector of metastatic renal carcinoma. J Urol. 1974 Sep;112(3):310–312. doi: 10.1016/s0022-5347(17)59716-5. [DOI] [PubMed] [Google Scholar]

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