Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1977 Apr;35(4):426–432. doi: 10.1038/bjc.1977.64

Cold lymphocytotoxic antibodies in nasopharyngeal carcinoma.

J P Lamelin, J P Revillard, J M Chalopin, J H Ho, T Souissi, G Schwaab, G De-Thé
PMCID: PMC2025356  PMID: 192260

Abstract

Sera from patients with nasopharyngeal carcinoma (NPC), a disease associated with Epstein-Barr virus (EBV), were found to be cytotoxic at 15% degrees C in the presence of complement for a panel of human lymphocytes, with a higher frequency than those of matched controls. The cold lymphocytotoxic antibodies (LTA) responsible for this activity have the same properties as those described in sera from individuals with acute viral infections. The frequency and geometric mean titres (GMT) of LTA varied with the origin of the patient (Chinese larger than North African larger than Caucasian) and the stage of the disease (Stage IV larger than Stage I). A positive correlation between LTA and anti-EBV titres was found with regard to antibodies to the viral capsid antigen (VCA) and the EBV-specified nuclear antigen (EBNA). The absence of correlation between LTA and anti-early antigen (EA) titres probable reflects the complex relationships existing between viral infection and LTA production, but is compatible with the hypothesis that LTA acts as an immune regulatory mechanism in viral infections.

Full text

PDF
426

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chan S. H., Chew T. S., Goh E. H., Simons M. J., Shanmugaratnam K. Impaired general cell-mediated immune functions in vivo and in vitro in patients with nasopharyngeal carcinoma. Int J Cancer. 1976 Aug 15;18(2):139–144. doi: 10.1002/ijc.2910180202. [DOI] [PubMed] [Google Scholar]
  2. DeHoratius R. J., Pillarisetty R., Messner R. P., Talal N. Anti-nucleic acid antibodies in systemic lupus erythematosus patients and their families. Incidence and correlation with lymphocytotoxic antibodies. J Clin Invest. 1975 Nov;56(5):1149–1154. doi: 10.1172/JCI108190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Desgranges C., Wolf H., De-Thé G., Shanmugaratnam K., Cammoun N., Ellouz R., Klein G., Lennert K., Muñoz N., Zur Hausen H. Nasopharyngeal carcinoma. X. Presence of epstein-barr genomes in separated epithelial cells of tumours in patients from Singapore, Tunisia and Kenya. Int J Cancer. 1975 Jul 15;16(1):7–15. doi: 10.1002/ijc.2910160103. [DOI] [PubMed] [Google Scholar]
  4. Henle G., Henle W. Immunofluorescence in cells derived from Burkitt's lymphoma. J Bacteriol. 1966 Mar;91(3):1248–1256. doi: 10.1128/jb.91.3.1248-1256.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Henle W., Henle G., Ho H. C., Burtin P., Cachin Y., Clifford P., de Schryver A., de-Thé G., Diehl V., Klein G. Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups. J Natl Cancer Inst. 1970 Jan;44(1):225–231. [PubMed] [Google Scholar]
  6. Henle W., Henle G., Zajac B. A., Pearson G., Waubke R., Scriba M. Differential reactivity of human serums with early antigens induced by Epstein-Barr virus. Science. 1970 Jul 10;169(3941):188–190. doi: 10.1126/science.169.3941.188. [DOI] [PubMed] [Google Scholar]
  7. Lies R. B., Messner R. P., Williams R. C., Jr Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus. Arthritis Rheum. 1973 May-Jun;16(3):369–375. doi: 10.1002/art.1780160312. [DOI] [PubMed] [Google Scholar]
  8. Mayer S., Falkenrodt A., Tongio M. M. Cold lymphocytotoxins in infections and parasitic infestations. Tissue Antigens. 1973;3(6):431–438. doi: 10.1111/j.1399-0039.1973.tb00513.x. [DOI] [PubMed] [Google Scholar]
  9. McDevitt H. O., Bodmer W. F. HL-A, immune-response genes, and disease. Lancet. 1974 Jun 22;1(7869):1269–1275. doi: 10.1016/s0140-6736(74)90021-x. [DOI] [PubMed] [Google Scholar]
  10. Mittal K. K., Rossen R. D., Sharp J. T., Lidsky M. D., Butler W. T. Lymphocyte cytotoxic antibodies in systemic lupus erythematosus. Nature. 1970 Mar 28;225(5239):1255–1256. doi: 10.1038/2251255a0. [DOI] [PubMed] [Google Scholar]
  11. Old L. J., Boyse E. A., Oettgen H. F., Harven E. D., Geering G., Williamson B., Clifford P. Precipitating antibody in human serum to an antigen present in cultured burkitt's lymphoma cells. Proc Natl Acad Sci U S A. 1966 Dec;56(6):1699–1704. doi: 10.1073/pnas.56.6.1699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ooi B. S., Orlina A. R., Pesce A. J., Mendoza N., Masaitis L., Pollak V. E. Lymphocytotoxic antibodies in patients with systemic lupus erythematosus. Clin Exp Immunol. 1974 Jun;17(2):237–243. [PMC free article] [PubMed] [Google Scholar]
  13. Reedman B. M., Klein G. Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines. Int J Cancer. 1973 May;11(3):499–520. doi: 10.1002/ijc.2910110302. [DOI] [PubMed] [Google Scholar]
  14. Simons M. J., Wee G. B., Chan S. H., Shanmugaratnam K. Probable identification of an HL-A second-locus antigen associated with a high risk of nasopharyngeal carcinoma. Lancet. 1975 Jan 18;1(7899):142–143. doi: 10.1016/s0140-6736(75)91433-6. [DOI] [PubMed] [Google Scholar]
  15. Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]
  16. Winchester R. J., Winfield J. B., Siegal F., Wernet P., Bentwich Z., Kunkel H. G. Analyses of lymphocytes from patients with rheumatoid arthritis and systemic lupus erythematosus. Occurrence of interfering cold-reactive antilymphocyte antibodies. J Clin Invest. 1974 Nov;54(5):1082–1092. doi: 10.1172/JCI107852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wolf H., zur Hausen H., Becker V. EB viral genomes in epithelial nasopharyngeal carcinoma cells. Nat New Biol. 1973 Aug 22;244(138):245–247. doi: 10.1038/newbio244245a0. [DOI] [PubMed] [Google Scholar]
  18. de Schryver A., Friberg S., Jr, Klein G., Henle W., Henle G., De-Thé G., Clifford P., Ho H. C. Epstein-Barr virus-associated antibody patterns in carcinoma of the post-nasal space. Clin Exp Immunol. 1969 Nov;5(5):443–459. [PMC free article] [PubMed] [Google Scholar]
  19. de-Thé G., Ho J. H., Ablashi D. V., Day N. E., Macario A. J., Martin-Berthelon M. C., Pearson G., Sohier R. Nasopharyngeal carcinoma. IX. Antibodies to EBNA and correlation with response to other ebv antigens in chinese patients. Int J Cancer. 1975 Nov 15;16(5):713–721. doi: 10.1002/ijc.2910160503. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES