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. 1977 Jul;36(1):105–113. doi: 10.1038/bjc.1977.160

Influence of tumour size on hypoxic fraction and therapeutic sensitivity of Lewis lung tumour.

J A Stanley, W U Shipley, G G Steel
PMCID: PMC2025447  PMID: 889677

Abstract

Radiation survival curves for Lewis lung tumours in the lungs ranging in size from 0-5 to 20 mm3 have been obtained, and a size-dependent variation in hypoxic fraction was found. Cell-survival studies following treatment of various sizes of s.c. tumours indicated that the effects of 60Co gamma-rays and the chemotherapeutic agents 1,3-bas(2-chloroethyl)-1-nitrosourea (BCNU) and cyclophosphamide are all size-dependent. Large pulmonary nodules which had regressed but had not been cured by cyclophosphamide regrew with a radiosensitivity that was characteristic of previously untreated tumours. The results give additional experimental support to the clinical interest in early adjuvant therapy of micrometastases, and sequential combined modality therapy for larger tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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