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. 1977 Aug;36(2):243–253. doi: 10.1038/bjc.1977.184

Spectral and metabolic characteristics of mitochondrial fractions from rotenone-induced tumours.

M Gosálvez, J Díaz-Gil, J Coloma, L Salganicoff
PMCID: PMC2025468  PMID: 911663

Abstract

Mitochondrial fractions isolated from tumours induced with the respiratory inhibitor rotenone lack respiratory control, oxidative phosphorylation, are partially or totally insensitive to cyanide and have a near-normal content of respiratory carriers. These characteristics are more similar to those of mitochondria from atrophic mammary gland than to those of mitochondria from spontaneous mammary adenomas. Thus, the characteristic structural and biochemical mitochondrial alteration of rotenone-induced tumours would represent a lack of mitochondrial differentiation as the tumour develops from the atrophic mammary gland. Slices of rotenone-induced tumours are insensitive to oligomycin and dinitrophenol, thus indicating that glycolysis would be their sole source of metabolic energy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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