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. 1977 May;35(5):528–536. doi: 10.1038/bjc.1977.86

Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.

G Biasi, D Collavo, A Colombatti, L Chieco-Bianchi
PMCID: PMC2025493  PMID: 140697

Abstract

Mitomycin-treated transplantable Moloney virus-induced lymphatic leukaemia cells (YC8) not only failed to stimulate normal allogeneic lymphocytes in one-way mixed leucocyte culture (MLC) but also exerted a strong inhibitory effect on the proliferative response of normal lymphocytes, in MLC and after stimulation by mitogens. Potentially inhibitory factors which could be released in the culture fluids by the YC8 cells were not found, but a YC8-derived adherent cell subpopulation was identified as being responsible for the in vitro suppression.

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Selected References

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