Abstract
Patients with acute lymphatic leukaemia (ALL) could be divided into two groups at diagnosis--those whose peripheral blood and/or bone marrow exhibited in vitro colony formation and those in whom it did not, but this finding did not appear to correlate with any clinical or haematological parameter, or with prognosis.The colonly-forming potential of patients with ALL in their first full remission, early relapse or second remission did not deviate significantly from previously established normal values, but the colony-forming potential of patients in early remission was very significantly reduced. No loss of colony-forming potential of normal marrow cells was noted when they were cultured with cells from patients with ALL.
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- Bradley T. R., Sumner M. A. Stimulation of mouse bone marrow colony growth in vitro by conditioned medium. Aust J Exp Biol Med Sci. 1968 Oct;46(5):607–618. doi: 10.1038/icb.1968.167. [DOI] [PubMed] [Google Scholar]
- Hulliger L., Blazkovec A. A. A simple and efficient method of separating peripheral-blood leucocytes for in-vitro studies. Lancet. 1967 Jun 17;1(7503):1304–1305. doi: 10.1016/s0140-6736(67)91596-6. [DOI] [PubMed] [Google Scholar]
- Mack T., Robinson W. A., Holton C. P. Colony growth of peripheral blood cells from patients with acute lymphocytic leukemia. Cancer Res. 1972 Oct;32(10):2054–2057. [PubMed] [Google Scholar]
- McNeill T. A. The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vitro. Immunology. 1971 Nov;21(5):741–750. [PMC free article] [PubMed] [Google Scholar]
- Moore M. A., Spitzer G., Williams N., Metcalf D., Buckley J. Agar culture studies in 127 cases of untreated acute leukemia: the prognostic value of reclassification of leukemia according to in vitro growth characteristics. Blood. 1974 Jul;44(1):1–18. [PubMed] [Google Scholar]
- Morris T. C., McNeill T. A., Bridges J. M. Characteristics of colony growth from normal human bone marrow. J Clin Pathol. 1974 Oct;27(10):776–782. doi: 10.1136/jcp.27.10.776. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morris T. C., McNeill T. A., Bridges J. M. Inhibition of normal human in vitro colony forming cells by cells from leukaemic patients. Br J Cancer. 1975 Jun;31(6):641–648. doi: 10.1038/bjc.1975.110. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ragab A. H., Gilkerson E. S., Myers M. L. Granulopoiesis in childhood leukemia. Cancer. 1974 Mar;33(3):791–797. doi: 10.1002/1097-0142(197403)33:3<791::aid-cncr2820330326>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
- Testa N. G., Lajtha L. G. Comparison of the kinetics of colony forming units in spleen (CFU S ) and culture (CFU C ). Br J Haematol. 1973 Mar;24(3):367–376. doi: 10.1111/j.1365-2141.1973.tb01660.x. [DOI] [PubMed] [Google Scholar]