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. 1977 Jun;35(6):809–815. doi: 10.1038/bjc.1977.122

Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.

E J Hall, M Astor, C Geard, J Biaglow
PMCID: PMC2025538  PMID: 871368

Abstract

The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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