Abstract
The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells.
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Selected References
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- Brown J. M. The effect of lung irradiation on the incidence of pulmonary metastases in mice. Br J Radiol. 1973 Aug;46(548):613–618. doi: 10.1259/0007-1285-46-548-613. [DOI] [PubMed] [Google Scholar]
- Cobb L. M. The influence of nitrogen mustard upon the establishment of lung metastases following injection of intravenous autologous cells in the benzo(a)pyrene-induced rat fibrosarcoma. Int J Cancer. 1968 Jul 15;3(4):504–510. doi: 10.1002/ijc.2910030411. [DOI] [PubMed] [Google Scholar]
- Dao T. L., Yogo H. Enhancement of pulmonary metastases by x-irradiation in rats bearing mammary cancer. Cancer. 1967 Nov;20(11):2020–2025. doi: 10.1002/1097-0142(196711)20:11<2020::aid-cncr2820201131>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
- Gould V. E., Miller J. Sclerosing alveolitis induced by cyclophosphamide. Ultrastructural observations on alveolar injury and repair. Am J Pathol. 1975 Dec;81(3):513–530. [PMC free article] [PubMed] [Google Scholar]
- Hill R. P., Bush R. S. A lung-colony assay to determine the radiosensitivity of cells of a solid tumour. Int J Radiat Biol Relat Stud Phys Chem Med. 1969 Jul;15(5):435–444. doi: 10.1080/09553006914550721. [DOI] [PubMed] [Google Scholar]
- Hill R. P., Stanley J. A. The lung-colony assay: extension to the Lewis lung tumour and the B16 melanoma--radiosensitivity of B16 melanoma cells. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Apr;27(4):377–387. doi: 10.1080/09553007514550351. [DOI] [PubMed] [Google Scholar]
- Hoover H. C., Jr, Ketcham A. S. Techniques for inhibiting tumor metastases. Cancer. 1975 Jan;35(1):5–14. doi: 10.1002/1097-0142(197501)35:1<5::aid-cncr2820350103>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
- Peters L. J., Hewitt H. B. The influence of fibrin formation on the transplantability of murine tumour cells: implications for the mechanism of the Révész effect. Br J Cancer. 1974 Apr;29(4):279–291. doi: 10.1038/bjc.1974.68. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steel G. G., Adams K. Stem-cell survival and tumor control in the Lewis lung carcinoma. Cancer Res. 1975 Jun;35(6):1530–1535. [PubMed] [Google Scholar]
- Withers H. R., Milas L. Influence of preirradiation of lung on development of artificial pulmonary metastases of fibrosarcoma in mice. Cancer Res. 1973 Aug;33(8):1931–1936. [PubMed] [Google Scholar]
- van den Brenk H. A., Kelly H. Potentiating effect of prior local irradiation of the lungs on pulmonary metastases. Br J Radiol. 1974 Jun;47(558):332–336. doi: 10.1259/0007-1285-47-558-332. [DOI] [PubMed] [Google Scholar]