Skip to main content
NCBI home page
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1989 Sep;55(9):2195–2199. doi: 10.1128/aem.55.9.2195-2199.1989

New modified trichothecenes accumulated in solid culture by mutant strains of Fusarium sporotrichioides.

S P McCormick 1, S L Taylor 1, R D Plattner 1, M N Beremand 1
PMCID: PMC203055  PMID: 2802605

Abstract

Mutant strains of Fusarium sporotrichioides NRRL 3299 deficient in the ability to synthesize T-2 toxin were examined on solid rice medium. Five novel alicyclic trichothecenes were isolated: 11 alpha-hydroxytrichodiene; tricho-9-ene-2 alpha,3 alpha,11 alpha-triol; tricho-9-ene-2 alpha,3 alpha,8 alpha,11 alpha-tetraol; tricho-9-ene-2 alpha,3 alpha,8 beta,11 alpha-tetraol; and tricho-9-ene-2 alpha,3 alpha,11 alpha,16-tetraol.

Full text

PDF
2195

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett J. W., Lee L. S., Shoss S. M., Boudreaux G. H. Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway. Appl Environ Microbiol. 1980 Apr;39(4):835–839. doi: 10.1128/aem.39.4.835-839.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beremand M. N. Isolation and characterization of mutants blocked in T-2 toxin biosynthesis. Appl Environ Microbiol. 1987 Aug;53(8):1855–1859. doi: 10.1128/aem.53.8.1855-1859.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burmeister H. R. T-2 toxin production by Fusarium tricinctum on solid substrate. Appl Microbiol. 1971 Apr;21(4):739–742. doi: 10.1128/am.21.4.739-742.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Corley D. G., Rottinghaus G. E., Tempesta M. S. Secondary metabolites from Fusarium. Two new modified trichothecenes from Fusarium sporotrichioides MC-72083. J Nat Prod. 1987 Sep-Oct;50(5):897–902. doi: 10.1021/np50053a021. [DOI] [PubMed] [Google Scholar]
  5. Desjardins A. E., Plattner R. D., Vanmiddlesworth F. Trichothecene Biosynthesis in Fusarium sporotrichioides: Origin of the Oxygen Atoms of T-2 Toxin. Appl Environ Microbiol. 1986 Mar;51(3):493–497. doi: 10.1128/aem.51.3.493-497.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Grove J. F. Non-macrocyclic trichothecenes. Nat Prod Rep. 1988 Apr;5(2):187–209. doi: 10.1039/np9880500187. [DOI] [PubMed] [Google Scholar]
  7. Hammock L. G., Hammock B. D., Casida J. E. Detection and analysis of epoxides with 4-(p-Nitrobenzyl)-pyridine. Bull Environ Contam Toxicol. 1974 Dec;12(6):759–764. doi: 10.1007/BF01685927. [DOI] [PubMed] [Google Scholar]
  8. Jarvis B. B., Lee Y. W., Yatawara C. S., Mazzocchi D. B., Flippen-Anderson J. L., Gilardi R., George C. 7 alpha-hydroxytrichodermol, a new trichothecene from Myrothecium roridum. Appl Environ Microbiol. 1985 Nov;50(5):1225–1228. doi: 10.1128/aem.50.5.1225-1228.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lee L. S., Bennett J. W., Cucullu A. F., Stanley J. B. Synthesis of versicolorin A by a mutant strain of Aspergillus parasiticus deficient in aflatoxin production. J Agric Food Chem. 1975 Nov-Dec;23(6):1132–1134. doi: 10.1021/jf60202a011. [DOI] [PubMed] [Google Scholar]
  10. Lee Y. W., Mirocha C. J. Production of Nivalenol and Fusarenone-X by Fusarium tricinctum Fn-2B on a Rice Substrate. Appl Environ Microbiol. 1984 Oct;48(4):857–858. doi: 10.1128/aem.48.4.857-858.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Plattner R. D., Tjarks L. W., Beremand M. N. Trichothecenes accumulated in liquid culture of a mutant of Fusarium sporotrichioides NRRL 3299. Appl Environ Microbiol. 1989 Sep;55(9):2190–2194. doi: 10.1128/aem.55.9.2190-2194.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Takitani S., Asabe Y., Kato T., Suzuki M., Ueno Y. Spectrodensitometric determination of trichothecene mycotoxins with 4-(p-nitrobenzyl)pyridine on silica gel thin-layer chromatograms. J Chromatogr. 1979 Apr 21;172:335–342. doi: 10.1016/s0021-9673(00)90970-1. [DOI] [PubMed] [Google Scholar]
  13. Wei C. M., McLaughlin C. S. Structure-function relationship in the 12,13-epoxytrichothecenes. Novel inhibitors of protein synthesis. Biochem Biophys Res Commun. 1974 Apr 8;57(3):838–844. doi: 10.1016/0006-291x(74)90622-6. [DOI] [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES