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. 1989 Sep;55(9):2275–2279. doi: 10.1128/aem.55.9.2275-2279.1989

Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans.

C E Cerniglia 1, W L Campbell 1, J P Freeman 1, F E Evans 1
PMCID: PMC203068  PMID: 2802607

Abstract

The metabolism of phenanthrene by the fungus Cunninghamella elegans was investigated. Kinetic experiments using [9-14C]phenanthrene showed that after 72 h, 53% of the total radioactivity was associated with a glucoside conjugate of 1-hydroxyphenanthrene (phenanthrene 1-O-beta-glucose). This metabolite was isolated by reversed-phase high-performance liquid chromatography and characterized by the application of UV absorption, 1H nuclear magnetic resonance, and mass spectral techniques. The results show that aromatic ring oxidation followed by glucosylation is a predominant pathway in the metabolism of the polycyclic aromatic hydrocarbon phenanthrene by C. elegans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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