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. 1989 Sep;55(9):2416–2419. doi: 10.1128/aem.55.9.2416-2419.1989

The conjugative plasmid pTR2030 encodes two bacteriophage defense mechanisms in lactococci, restriction modification (R+/M+) and abortive infection (Hsp+).

C Hill 1, K Pierce 1, T R Klaenhammer 1
PMCID: PMC203092  PMID: 2508558

Abstract

pTR2030 is a conjugative plasmid which encodes resistance to bacteriophage in lactococci by a mechanism that aborts the phage infection (Hsp+). Subcloning and in vivo deletion events showed that two independent mechanisms of resistance are located on a 13.6-kilobase Bg/II fragment cloned in pSA3; one mechanism is responsible for the abortive infection, and the other incodes a restriction modification system. The introduction of pTR2030 or the recombinant plasmid pTK6 resulted in the loss of a resident restriction modification plasmid in Lactococcus lactis NCK202 which was not previously identified.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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