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. 1977 Jan;86(1):149–162.

Target-cell membrane alterations induced by lymphotoxin. Ultrastructural observations.

D S Friend, W Rosenau
PMCID: PMC2032054  PMID: 299796

Abstract

Upon in vitro stimulation by antigens or mitogens, lymphocytes release a series of lymphokines. One such lymphocyte mediator is lymphotoxin, which appears to be responsible for in vitro lymphocyte-mediated cytolysis. Employing immuno-electron microscopy with ferritin- or peroxidase-labeled antibody, we observed patchy localization of the mediator on the plasma membranes of target L cells exposed to lymphotoxin, often in areas overlying a microfilament web. When studying lymphotoxin-affected cells by electron microscopy of freeze-fracture replicas, we observed aggrlasma membrane, with intervening areas which were frequently particle free. Sometimes the affected cells revealed plasma-membrane lesions suggesting intramembranous "blisters."

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159Figure 6
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159Figure 7
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160Figure 8A and B
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161Figure 9
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161Figure 10
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161Figure 11
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162Figures 12-13
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157Figure 1
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157Figures 2-5
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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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