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. 1977 Apr;87(1):228–264.

Pathologic aspects of cirrhosis. A review.

H Popper
PMCID: PMC2032069  PMID: 322505

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anthony P. P. Precursor lesions for liver cancer in humans. Cancer Res. 1976 Jul;36(7 Pt 2):2579–2583. [PubMed] [Google Scholar]
  2. Anthony P. P., Vogel C. L., Sadikali F., Barker L. F., Peterson M. R. Hepatitis-associated antigen and antibody in Uganda: correlation of serological testing with histopathology. Br Med J. 1972 Feb 12;1(5797):403–406. doi: 10.1136/bmj.1.5797.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BAGGENSTOSS A. H., STAUFFER M. H. Posthepatitic and alcoholic cirrhosis: clinicopathologic study of 43 cases of each. Gastroenterology. 1952 Oct;22(2):157–180. [PubMed] [Google Scholar]
  4. BENZ E. J., BAGGENSTOSS A. H. Focal cirrhosis of the liver: its relation to the so-called hamartoma (adenoma, benign hepatoma). Cancer. 1953 Jul;6(4):743–755. doi: 10.1002/1097-0142(195307)6:4<743::aid-cncr2820060413>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  5. Baggenstoss A. H., Soloway R. D., Summerskill W. H., Elveback L. R., Schoenfield L. J. Chronic active liver disease. The range of histologic lesions, their response to treatment, and evolution. Hum Pathol. 1972 Jun;3(2):183–198. doi: 10.1016/s0046-8177(72)80072-8. [DOI] [PubMed] [Google Scholar]
  6. Baraona E., Leo M. A., Borowsky S. A., Lieber C. S. Alcoholic hepatomegaly: accumulation of protein in the liver. Science. 1975 Nov 21;190(4216):794–795. doi: 10.1126/science.1198096. [DOI] [PubMed] [Google Scholar]
  7. Barrett P. V. Effects of caloric and noncaloric materials in fasting hyperbilirubinemia. Gastroenterology. 1975 Feb;68(2):361–369. [PubMed] [Google Scholar]
  8. Barry M. Iron and the liver. Gut. 1974 Apr;15(4):324–334. doi: 10.1136/gut.15.4.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bhathal P. S., Hurley J. V. An electron microscope study of the production of ascites in acute dimethylnitrosamine (DMN)-induced liver injury. J Pathol. 1973 Oct;111(2):103–116. doi: 10.1002/path.1711110205. [DOI] [PubMed] [Google Scholar]
  10. Bircher J., Blankart R., Halpern A., Häcki W., Laissue J., Preisig R. Criteria for assessment of functional impairment in patients with cirrhosis of the liver. Eur J Clin Invest. 1973 Jan;3(1):72–85. doi: 10.1111/j.1365-2362.1973.tb00332.x. [DOI] [PubMed] [Google Scholar]
  11. Black M., Mitchell J. R., Zimmerman H. J., Ishak K. G., Epler G. R. Isoniazid-associated hepatitis in 114 patients. Gastroenterology. 1975 Aug;69(2):289–302. [PubMed] [Google Scholar]
  12. Borchard F., Borchard H., Huth F. Beitrag zur lymphvasculären Sklerose des Ductus thoracicus. Morphometrische Untersuchungen von 88 Fällen. Beitr Pathol. 1972 May;146(2):145–161. [PubMed] [Google Scholar]
  13. Boyer J. L., Klatskin G. Pattern of necrosis in acute viral hepatitis. Prognostic value of bridging (subacute hepatic necrosis). N Engl J Med. 1970 Nov 12;283(20):1063–1071. doi: 10.1056/NEJM197011122832001. [DOI] [PubMed] [Google Scholar]
  14. Bronfenmajer S., Schaffner F., Popper H. Fat-storing cells (lipocytes) in human liver. Arch Pathol. 1966 Nov;82(5):447–453. [PubMed] [Google Scholar]
  15. Burchell A. R., Moreno A. H., Panke W. F., Nealon T. F., Jr Hemodynamic variables and prognosis following portacaval shunts. Surg Gynecol Obstet. 1974 Mar;138(3):359–369. [PubMed] [Google Scholar]
  16. Chanuvati T., Viranuvatti V., Pongpipat D. Relationship of hepatitis B antigen in cirrhosis and hepatoma in Thailand. An etiological significance. Gastroenterology. 1975 May;68(5 Pt 1):1261–1264. [PubMed] [Google Scholar]
  17. Chen T. S., Leevy C. M. Collagen biosynthesis in liver disease of the alcoholic. J Lab Clin Med. 1975 Jan;85(1):103–112. [PubMed] [Google Scholar]
  18. Chung E., Rhodes K., Miller E. J. Isolation of three collagenous components of probable basement membrane origin from several tissues. Biochem Biophys Res Commun. 1976 Aug 23;71(4):1167–1174. doi: 10.1016/0006-291x(76)90776-2. [DOI] [PubMed] [Google Scholar]
  19. Classen M., Elster K., Pesch H. J., Demling L. Portal hypertension caused by partial nodular transformation of the liver. Gut. 1970 Mar;11(3):245–249. doi: 10.1136/gut.11.3.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Conn H. O., Fessel J. M. Spontaneous bacterial peritonitis in cirrhosis: variations on a theme. Medicine (Baltimore) 1971 May;50(3):161–197. doi: 10.1097/00005792-197105000-00002. [DOI] [PubMed] [Google Scholar]
  21. DOEHLERT C. A., Jr, BAGGENSTOSS A. H., CAIN J. C. Obstructive biliary cirrhosis and alcoholic cirrhosis; comparison of clinical and pathologic features. Am J Clin Pathol. 1955 Aug;25(8):902–914. doi: 10.1093/ajcp/25.8.902. [DOI] [PubMed] [Google Scholar]
  22. De Groote J., Desmet V. J., Gedigk P., Korb G., Popper H., Poulsen H., Scheuer P. J., Schmid M., Thaler H., Uehlinger E. A classification of chronic hepatitis. Lancet. 1968 Sep 14;2(7568):626–628. doi: 10.1016/s0140-6736(68)90710-1. [DOI] [PubMed] [Google Scholar]
  23. De Vos R., de Wolf-Peeters C., Desmet V., Eggermont E., Van Acker K. Progressive intrahepatic cholestasis (Byler's disease): case report. Gut. 1975 Dec;16(12):943–950. doi: 10.1136/gut.16.12.943. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Dietrichson O. Chronic persistent hepatitis. A clinical, serological, and prognostic study. Scand J Gastroenterol. 1975;10(3):249–255. [PubMed] [Google Scholar]
  25. Donovan A. J., Child M. A., Masto A. S. The effect of hepatic venous obstruction on the rate of flow of bile. Surg Gynecol Obstet. 1972 Jan;134(1):89–93. [PubMed] [Google Scholar]
  26. Dudley F. J., Fox R. A., Sherlock S. Relationship of hepatitis-associated antigen (H.A.A.) to acute and chronic liver injury. Lancet. 1971 Jul 3;2(7714):1–3. doi: 10.1016/s0140-6736(71)90001-8. [DOI] [PubMed] [Google Scholar]
  27. EDMONDSON H. A., PETERS R. L., REYNOLDS T. B., KUZMA O. T. SCLEROSING HYALINE NECROSIS OF THE LIVER IN THE CHRONIC ALCOHOLIC. A RECOGNIZABLE CLINICAL SYNDROME. Ann Intern Med. 1963 Nov;59:646–673. doi: 10.7326/0003-4819-59-5-646. [DOI] [PubMed] [Google Scholar]
  28. Edgington T. S., Chisari F. V. Immunological aspects of hepatitis B virus infection. Am J Med Sci. 1975 Sep-Oct;270(2):212–227. [PubMed] [Google Scholar]
  29. Eriksson S., Hägerstrand I. Cirrhosis and malignant hepatoma in alpha 1-antitrypsin deficiency. Acta Med Scand. 1974 Jun;195(6):451–458. doi: 10.1111/j.0954-6820.1974.tb08170.x. [DOI] [PubMed] [Google Scholar]
  30. Fagrell B., Strandberg I., Wengle B. A nitrofurantoin-induced disorder simulating chronic active hepatitis. A case report. Acta Med Scand. 1976;199(3):237–239. doi: 10.1111/j.0954-6820.1976.tb06724.x. [DOI] [PubMed] [Google Scholar]
  31. Farber E. Pathogenesis of liver cancer. Arch Pathol. 1974 Sep;98(3):145–148. [PubMed] [Google Scholar]
  32. Feizi O. Hereditary hemorrhagic telangiectasia presenting with portal hypertension and cirrhosis of the liver. A case report. Gastroenterology. 1972 Oct;63(4):660–664. [PubMed] [Google Scholar]
  33. Fellows K. E., Grand R. J., Colodny A. H., Orsini E. N., Crocker A. C. Combined portal and vena caval hypertension in Gaucher disease: The value of preoperative venography. J Pediatr. 1975 Nov;87(5):739–743. doi: 10.1016/s0022-3476(75)80297-6. [DOI] [PubMed] [Google Scholar]
  34. Fleming C. R., Dickson E. R., Baggenstoss A. H., McCall J. T. Copper and primary biliary cirrhosis. Gastroenterology. 1974 Dec;67(6):1182–1187. [PubMed] [Google Scholar]
  35. Fujiwara K., Sakai T., Oda T., Igarashi S. The presence of collagenase in Kupffer cells of the rat liver. Biochem Biophys Res Commun. 1973 Sep 18;54(2):531–537. doi: 10.1016/0006-291x(73)91454-x. [DOI] [PubMed] [Google Scholar]
  36. GALL E. A. Posthepatitic, postnecrotic, and nutritional cirrhosis: a pathologic analysis. Am J Pathol. 1960 Mar;36:241–271. [PMC free article] [PubMed] [Google Scholar]
  37. Galbraith R. M., el Sheikh N., Portmann B., Eddleston A. L., Williams R., Parsons V., Bewick M., Ogg C. S. Immune response to HBsAg and the spectrum of liver lesions in HBsAg-positive patients with chronic renal disease. Br Med J. 1976 Jun 19;1(6024):1495–1497. doi: 10.1136/bmj.1.6024.1495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Gay S., Martin G. R., Muller P. K., Timpl R., Kuhn K. Simultaneous synthesis of types I and III collagen by fibroblasts in culture. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4037–4040. doi: 10.1073/pnas.73.11.4037. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Gerber M. A., Orr W., Denk H., Schaffner F., Popper H. Hepatocellular hyalin in cholestasis and cirrhosis: its diagnostic significance. Gastroenterology. 1973 Jan;64(1):89–98. [PubMed] [Google Scholar]
  40. Gerber M. A., Popper H. Relation between central canals and portal tracts in alcoholic hepatitis. A contribution to the pathogenesis of cirrhosis in alcoholics. Hum Pathol. 1972 Jun;3(2):199–207. doi: 10.1016/s0046-8177(72)80073-x. [DOI] [PubMed] [Google Scholar]
  41. Ginsberg M. D. Spontaneous group B streptococcal bacteremia complicating hepatic cirrhosis. Report of two cases. Am J Dig Dis. 1968 Dec;13(12):1065–1071. doi: 10.1007/BF02233551. [DOI] [PubMed] [Google Scholar]
  42. Goldberg B., Taubman M. B., Radin A. Procollagen peptidase: its mode of action on the native substrate. Cell. 1975 Jan;4(1):45–50. doi: 10.1016/0092-8674(75)90132-4. [DOI] [PubMed] [Google Scholar]
  43. Gordon H. W., Dixon J., Rogers J. C., Mittman C., Lieberman J. Alpha 1 -antitrypsin (A1AT) accumulation in livers of emphysematous patients with A1AT deficiency. Hum Pathol. 1972 Sep;3(3):361–370. doi: 10.1016/s0046-8177(72)80037-6. [DOI] [PubMed] [Google Scholar]
  44. Gross G., Perrier C. V. Letter: Intrahepatic portasystemic shunting in cirrhotic patients. N Engl J Med. 1975 Nov 13;293(20):1046–1047. doi: 10.1056/NEJM197511132932017. [DOI] [PubMed] [Google Scholar]
  45. Hadchouel M., Gautier M. Histopathologic study of the liver in the early cholestatic phase of alpha-1-antitrypsin deficiency. J Pediatr. 1976 Aug;89(2):211–215. doi: 10.1016/s0022-3476(76)80450-7. [DOI] [PubMed] [Google Scholar]
  46. Hahn E., Timpl R., Miller E. J. The production of specific antibodies to native collagens with the chain compositions, (alpha1(I))3, (alpha1(II))3, and (alpha1(I))2alpha 2. J Immunol. 1974 Jul;113(1):421–423. [PubMed] [Google Scholar]
  47. Hartroft W. S., Porta E. A. Fibrogenic effect of alcohol in rat liver: role of diet. Science. 1973 Jan 26;179(4071):406–407. doi: 10.1126/science.179.4071.406. [DOI] [PubMed] [Google Scholar]
  48. Hathway D., Harris J. W., Stenger R. J. Histopathology of the liver in pyridoxine-responsive anemia. Arch Pathol. 1967 Feb;83(2):175–179. [PubMed] [Google Scholar]
  49. Hopf U., Meyer zum Büschenfelde K. H., Arnold W. Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis. N Engl J Med. 1976 Mar 11;294(11):578–582. doi: 10.1056/NEJM197603112941103. [DOI] [PubMed] [Google Scholar]
  50. Horisawa M., Goldstein G., Waxman A., Reynolds T. The abnormal hepatic scan of chronic liver disease: its relationship to hepatic hemodynamics and colloid extraction. Gastroenterology. 1976 Aug;71(2):210–213. [PubMed] [Google Scholar]
  51. Horisawa M., Yokoyama T., Juttner H., Reynolds T. B. Incomplete membranous obstruction of the inferior vena cava. Hemodynamic measurements and correction by balloon membranotomy and surgical resection. Arch Surg. 1976 May;111(5):599–602. doi: 10.1001/archsurg.1976.01360230099021. [DOI] [PubMed] [Google Scholar]
  52. Hruban Z., Russell R. M., Boyer J. L., Glagov S., Bagheri S. A. Ultrastructural changes in livers of two patients with hypervitaminosis A. Am J Pathol. 1974 Sep;76(3):451–461. [PMC free article] [PubMed] [Google Scholar]
  53. Huet P. M., Marleau D., Lavoie P., Viallet A. Extraction of 125I-albumin microaggregates from portal blood. An index of functional portal blood supply in cirrhotics. Gastroenterology. 1976 Jan;70(1):74–81. [PubMed] [Google Scholar]
  54. Hutterer F. Degradation of mucopolysaccharides by hepatic lysosomes. Biochim Biophys Acta. 1966 Feb 28;115(2):312–319. doi: 10.1016/0304-4165(66)90430-2. [DOI] [PubMed] [Google Scholar]
  55. Ishak K. G., Jenis E. H., Marshall M. L., Bolton B. H., Battistone G. C. Cirrhosis of the liver associated with 1 -antitrypsin deficiency. Arch Pathol. 1972 Nov;94(5):445–455. [PubMed] [Google Scholar]
  56. KENT G., FELS I. G., DUBIN A., POPPER H. Collagen content based on hydroxyproline determinations in human and rat livers; its relation to morphologically demonstrable reticulum and collagen fibers. Lab Invest. 1959 Jan-Feb;8(1):48–56. [PubMed] [Google Scholar]
  57. KLATSKIN G., YESNER R. Hepatic manifestations of sarcoidosis and other granulomatous diseases; a study based on histological examination of tissue obtained by needle biopsy of the liver. Yale J Biol Med. 1950 Dec;23(3):207–248. [PMC free article] [PubMed] [Google Scholar]
  58. Kaneda M., Takahashi T. Histometrical analysis of hepatic parenchyma in normal and cirrhotic livers. Tohoku J Exp Med. 1970 Mar;100(3):201–225. doi: 10.1620/tjem.100.201. [DOI] [PubMed] [Google Scholar]
  59. Karvountzis G. G., Redeker A. G., Peters R. L. Long term follow-up studies of patients surviving fluminant viral hepatitis. Gastroenterology. 1974 Nov;67(5):870–877. [PubMed] [Google Scholar]
  60. Kent G., Gay S., Inouye T., Bahu R., Minick O. T., Popper H. Vitamin A-containing lipocytes and formation of type III collagen in liver injury. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3719–3722. doi: 10.1073/pnas.73.10.3719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Kerr J. F., Wyllie A. H., Currie A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972 Aug;26(4):239–257. doi: 10.1038/bjc.1972.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Knowles D. M., 2nd, Kaye G. I., Godman G. C. Nodular regenerative hyperplasia of the liver. Gastroenterology. 1975 Sep;69(3):746–751. [PubMed] [Google Scholar]
  63. Krieg D., Weigl E. Epidemiologische Untersuchungen zum Problem der posthepatitischen Leberzirrhose. Acta Hepatosplenol. 1969 Jan-Feb;16(1):25–34. [PubMed] [Google Scholar]
  64. Langness U., Udenfriend S. Collagen biosynthesis in nonfibroblastic cell lines. Proc Natl Acad Sci U S A. 1974 Jan;71(1):50–51. doi: 10.1073/pnas.71.1.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Lee F. I. Cirrhosis and hepatoma in alcoholics. Gut. 1966 Feb;7(1):77–85. doi: 10.1136/gut.7.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Lieber C. S., DeCarli L., Rubin E. Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets. Proc Natl Acad Sci U S A. 1975 Feb;72(2):437–441. doi: 10.1073/pnas.72.2.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Ludwig J., Elveback L. R. Parenchyma weight changes in hepatic cirrhosis. A morphometric study and disscussion of the method. Lab Invest. 1972 Mar;26(3):338–343. [PubMed] [Google Scholar]
  68. Ludwig J., Garrison C. O., Baggenstoss A. H. Latent hepatic cirrhosis. A study of 95 cases. Am J Dig Dis. 1970 Jan;15(1):7–14. doi: 10.1007/BF02239341. [DOI] [PubMed] [Google Scholar]
  69. Ludwig J., Linhart P., Baggenstoss A. H. Hepatic lymph drainage in cirrhosis and congestive heart failure. A postmortem lymphangiographic study. Arch Pathol. 1968 Nov;86(5):551–562. [PubMed] [Google Scholar]
  70. MASUKO K., RUBIN E., POPPER H. PROLIFERATION OF BILE DUCTS IN CIRRHOSIS. Arch Pathol. 1964 Oct;78:421–431. [PubMed] [Google Scholar]
  71. MEISTER H. P., SZANTO P. B., SCHOOLMAN H. Quantitative-morphologic evaluation of postnecrotic cirrhosis. Virchows Arch Pathol Anat Physiol Klin Med. 1963;336:447–464. doi: 10.1007/BF00973027. [DOI] [PubMed] [Google Scholar]
  72. MORGAN J. D., HARTROFT W. S. Juvenile liver. Age at which one-cell-thick plates predominate in the human liver. Arch Pathol. 1961 Jan;71:86–88. [PubMed] [Google Scholar]
  73. MacSween R. N., Scott A. R. Hepatic cirrhosis: a clinico-pathological review of 520 cases. J Clin Pathol. 1973 Dec;26(12):936–942. doi: 10.1136/jcp.26.12.936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Maderazo E. C., Ward P. A., Quintiliani R. Defective regulation of chemotaxis in cirrhosis. J Lab Clin Med. 1975 Apr;85(4):621–630. [PubMed] [Google Scholar]
  75. McGee J. O., O'Hare R. P., Patrick R. S. Stimulation of the collagen biosynthetic pathway by factors isolated from experimentally-injured liver. Nat New Biol. 1973 May 23;243(125):121–123. [PubMed] [Google Scholar]
  76. McGee J. O., Patrick R. S., Rodger M. C., Luty C. M. Collagen proline hydroxylase activity and 35S sulphate uptake in human liver biopsies. Gut. 1974 Apr;15(4):260–267. doi: 10.1136/gut.15.4.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. McGee J. O., Patrick R. S. The role of perisinusoidal cells in hepatic fibrogenesis. An electron microscopic study of acute carbon tetrachloride liver injury. Lab Invest. 1972 Apr;26(4):429–440. [PubMed] [Google Scholar]
  78. Mezey E., Potter J. J., Maddrey W. C. Hepatic collagen proline hydroxylase activity in alcoholic liver disease. Clin Chim Acta. 1976 May 3;68(3):313–320. doi: 10.1016/0009-8981(76)90397-1. [DOI] [PubMed] [Google Scholar]
  79. Miller E. J., Matukas V. J. Biosynthesis of collagen. The biochemist's view. Fed Proc. 1974 May;33(5):1197–1204. [PubMed] [Google Scholar]
  80. Minor R. R., Clark C. C., Strause E. L., Koszalka T. R., Brent R. L., Kefalides N. A. Basement membrane procollagen is not converted to collagen in organ cultures of parietal yolk sac endoderm. J Biol Chem. 1976 Mar 25;251(6):1789–1794. [PubMed] [Google Scholar]
  81. Mitra S. K. Hepatic vascular changes in human and experimental cirrhosis. J Pathol Bacteriol. 1966 Oct;92(2):405–414. doi: 10.1002/path.1700920219. [DOI] [PubMed] [Google Scholar]
  82. Moreno A. H., Burchell A. R., Reddy R. V., Steen J. A., Panke W. F., Nealson T. F., Jr Spontaneous reversal of portal blood flow: the case for and against its occurrence in patients with cirrhosis of the liver. Ann Surg. 1975 Mar;181(3):346–358. doi: 10.1097/00000658-197503000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Morrow R. H., Sai F. T., Barker L. F. Australia antigen and hepatitis in Accra, Ghana. Br Med J. 1971 Nov 13;4(5784):389–391. doi: 10.1136/bmj.4.5784.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Nolan J. P. The role of endotoxin in liver injury. Gastroenterology. 1975 Dec;69(6):1346–1356. [PubMed] [Google Scholar]
  85. Nowack H., Gay S., Wick G., Becker U., Timpl R. Preparation and use in immunohistology of antibodies specific for type I and type III collagen and procollagen. J Immunol Methods. 1976;12(1-2):117–124. doi: 10.1016/0022-1759(76)90101-0. [DOI] [PubMed] [Google Scholar]
  86. Nyfors A., Poulsen H. Liver biopsies from psoriatics related to methotrexate therapy. 2. Findings before and after methotexate therapy in 88 patients. A blind study. Acta Pathol Microbiol Scand A. 1976 May;84(3):262–270. [PubMed] [Google Scholar]
  87. Odièvre M., Martin J. P., Hadchouel M., Alagille D. Alpha1-antitrypsin deficiency and liver disease in children: phenotypes, manifestations, and prognosis. Pediatrics. 1976 Feb;57(2):226–231. [PubMed] [Google Scholar]
  88. Orloff M. J., Chandler J. G., Alderman S. J., Keiter J. E., Rosen H. Gastric secretion and peptic ulcer following portacaval shunt in man. Ann Surg. 1969 Oct;170(4):515–527. doi: 10.1097/00000658-196910000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. PERHEENTUPA J., PITKANEN E., NIKKILA E. A., SOMERSALO O., HAKOSALO J. Hereditary fructose intolerance. A clinical study of four cases. Ann Paediatr Fenn. 1962;8:221–235. [PubMed] [Google Scholar]
  90. PHILLIPS M. J., STEINER J. W. ELECTRON MICROSCOPY OF LIVER CELLS IN CIRRHOTIC NODULES. I. THE LATERAL CELL MEMBRANES. Am J Pathol. 1965 Jun;46:985–1005. [PMC free article] [PubMed] [Google Scholar]
  91. POPPER H., ELIAS H. Histogenesis of hepatic cirrhosis studied by the threedimensional approach. Am J Pathol. 1955 May-Jun;31(3):405–441. [PMC free article] [PubMed] [Google Scholar]
  92. POPPER H., ELIAS H., PETTY D. E. Vascular pattern of the cirrhotic liver. Am J Clin Pathol. 1952 Aug;22(8):717–729. doi: 10.1093/ajcp/22.8.717. [DOI] [PubMed] [Google Scholar]
  93. POPPER H., SCHAFFNER F., BARKA T. Has proliferation of bile ductules clinical significance? Acta Hepatosplenol. 1962 May-Jun;9:129–139. [PubMed] [Google Scholar]
  94. POPPER H., STERNBERG S. S., OSER B. L., OSER M. The carcinogenic effect of aramite in rats. A study of hepatic nodules. Cancer. 1960 Sep-Oct;13:1035–1046. doi: 10.1002/1097-0142(196009/10)13:5<1035::aid-cncr2820130526>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  95. POPPER H., SZANTO P. B., ELIAS H. Transition of fatty liver into cirrhosis. Gastroenterology. 1955 Feb;28(2):183-92; discussion, 208-15. [PubMed] [Google Scholar]
  96. Paronetto F., Popper H. Two immunologic reactions in the pathogenesis of hepatitis? N Engl J Med. 1976 Mar 11;294(11):606–607. doi: 10.1056/NEJM197603112941110. [DOI] [PubMed] [Google Scholar]
  97. Partin J. S., Partin J. C., Schubert W. K., McAdams A. J. Liver ultrastructure in abetalipoproteinemia: Evolution of micronodular cirrhosis. Gastroenterology. 1974 Jul;67(1):107–118. [PubMed] [Google Scholar]
  98. Patek A. J., Jr, Toth I. G., Saunders M. G., Castro G. A., Engel J. J. Alcohol and dietary factors in cirrhosis. An epidemiological study of 304 alcoholic patients. Arch Intern Med. 1975 Aug;135(8):1053–1057. [PubMed] [Google Scholar]
  99. Perez V., Schaffner F., Popper H. Hepatic drug reactions. Prog Liver Dis. 1972;4:597–625. [PubMed] [Google Scholar]
  100. Peters R. L., Gay T., Reynolds T. B. Post-jejunoileal-bypass hepatic disease. Its similarity to alcoholic hepatic disease. Am J Clin Pathol. 1975 Mar;63(3):318–331. doi: 10.1093/ajcp/63.3.318. [DOI] [PubMed] [Google Scholar]
  101. Petrelli M., Scheuer P. J. Variation in subcapsular liver structure and its significance in the interpretation of wedge biopsies. J Clin Pathol. 1967 Sep;20(5):743–748. doi: 10.1136/jcp.20.5.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  102. Pettigrew N. M., Goudie R. B., Russell R. I., Chaudhuri A. K. Evidence for a role of hepatitis virus B in chronic alcoholic liver disease. Lancet. 1972 Oct 7;2(7780):724–725. doi: 10.1016/s0140-6736(72)92019-3. [DOI] [PubMed] [Google Scholar]
  103. Popper H., Orr W. Current concepts in cirrhosis. Scand J Gastroenterol Suppl. 1970;6:203–222. [PubMed] [Google Scholar]
  104. Popper H., Schaffner F. Hepatic cirrhosis. A problem in communication. Isr J Med Sci. 1968 Jan-Feb;4(1):1–7. [PubMed] [Google Scholar]
  105. Popper H., Uenfriend S. Hepatic fibrosis. Correlation of biochemical and morphologic investigations. Am J Med. 1970 Nov;49:707–721. doi: 10.1016/s0002-9343(70)80135-8. [DOI] [PubMed] [Google Scholar]
  106. Powell L. W., Kerr J. F. Reversal of "cirrhosis" in idiopathic haemochromatosis following long-term intensive venesection therapy. Australas Ann Med. 1970 Feb;19(1):54–57. doi: 10.1111/imj.1970.19.1.54. [DOI] [PubMed] [Google Scholar]
  107. Prytz H., Bjorneboe M., Johansen T. S., Orskov F. The influence of portosystemic shunt operation on immunoglobulins and Escherichia coli antibodies in patients with cirrhosis of the liver. Acta Med Scand. 1974 Jul-Aug;196(1-2):109–112. doi: 10.1111/j.0954-6820.1974.tb00976.x. [DOI] [PubMed] [Google Scholar]
  108. Purtilo D. T., Gottlieb L. S. Cirrhosis and hepatoma occurring at Boston City Hospital (1917-1968). Cancer. 1973 Aug;32(2):458–462. doi: 10.1002/1097-0142(197308)32:2<458::aid-cncr2820320225>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  109. ROBERTS W. C. The hepatic cirrhosis of cystic fibrosis of the pancreas. Am J Med. 1962 Feb;32:324–328. doi: 10.1016/0002-9343(62)90300-5. [DOI] [PubMed] [Google Scholar]
  110. RUBIN E., KRUS S., POPPER H. Pathogenesis of postnecrotic cirrhosis in alcoholics. Arch Pathol. 1962 Apr;73:288–299. [PubMed] [Google Scholar]
  111. RUBIN E., MASUKO K., GOLDFARB S., ZAK F. G. ROLE OF CELL PROLIFERATION IN HEPATIC CARCINOGENESIS. Proc Soc Exp Biol Med. 1964 Feb;115:381–384. doi: 10.3181/00379727-115-28919. [DOI] [PubMed] [Google Scholar]
  112. RUBIN E., SCHAFFNER F., POPPER H. PRIMARY BILIARY CIRRHOSIS. CHRONIC NON-SUPPURATIVE DESTRUCTIVE CHOLANGITIS. Am J Pathol. 1965 Mar;46:387–407. [PMC free article] [PubMed] [Google Scholar]
  113. Rappaport A. M. The microcirculatory acinar concept of normal and pathological hepatic structure. Beitr Pathol. 1976 May;157(3):215–243. doi: 10.1016/s0005-8165(76)80083-2. [DOI] [PubMed] [Google Scholar]
  114. Reynolds T. B., Hidemura R., Michel H., Peters R. Portal hypertension without cirrhosis in alcoholic liver disease. Ann Intern Med. 1969 Mar;70(3):497–506. doi: 10.7326/0003-4819-70-3-497. [DOI] [PubMed] [Google Scholar]
  115. Reynolds T. B., Peters R. L., Yamada S. Chronic active and lupoid hepatitis caused by a laxative, oxyphenisatin. N Engl J Med. 1971 Oct 7;285(15):813–820. doi: 10.1056/NEJM197110072851501. [DOI] [PubMed] [Google Scholar]
  116. Risdon R. A., Barry M., Flynn D. M. Transfusional iron overload: the relationship between tissue iron concentration and hepatic fibrosis in thalassaemia. J Pathol. 1975 Jun;116(2):83–95. doi: 10.1002/path.1711160204. [DOI] [PubMed] [Google Scholar]
  117. Risteli J., Kivirikko K. I. Activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in the liver of rats with hepatic injury. Biochem J. 1974 Oct;144(1):115–122. doi: 10.1042/bj1440115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  118. Rojkind M., Martinez-Palomo A. Increase in type I and type III collagens in human alcoholic liver cirrhosis. Proc Natl Acad Sci U S A. 1976 Feb;73(2):539–543. doi: 10.1073/pnas.73.2.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  119. Ross R., Glomset J. A. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973 Jun 29;180(4093):1332–1339. doi: 10.1126/science.180.4093.1332. [DOI] [PubMed] [Google Scholar]
  120. Rubin E., Popper H. The evolution of human cirrhosis deduced from observations in experimental animals. Medicine (Baltimore) 1967 Mar;46(2):163–183. doi: 10.1097/00005792-196703000-00009. [DOI] [PubMed] [Google Scholar]
  121. Rudzki C., Ishak K. G., Zimmerman H. J. Chronic intrahepatic cholestasis of sarcoidosis. Am J Med. 1975 Sep;59(3):373–387. doi: 10.1016/0002-9343(75)90396-4. [DOI] [PubMed] [Google Scholar]
  122. SCHAFFNER F., POPER H. Capillarization of hepatic sinusoids in man. Gastroenterology. 1963 Mar;44:239–242. [PubMed] [Google Scholar]
  123. SHALDON S., CHIANDUSSI L., GUEVARA L., CAESAR J., SHERLOCK S. The estimation of hepatic blood flow and intrahepatic shunted blood flow by colloidal heat-denatured human serum albumin labeled with I-131. J Clin Invest. 1961 Jul;40:1346–1354. doi: 10.1172/JCI104365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  124. SHERLOCK S. The liver in heart failure; relation of anatomical, functional, and circulatory changes. Br Heart J. 1951 Jul;13(3):273–293. doi: 10.1136/hrt.13.3.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  125. SIDBURY J. B., Jr, MASON J., BURNS W. B., Jr, RUEBNER B. H. Type IV glycogenosis. Report of a case proven by characterization of glycogen and studied at necropsy. Bull Johns Hopkins Hosp. 1962 Sep;111:157–181. [PubMed] [Google Scholar]
  126. SMETANA H. F., OLEN E. Hereditary galactose disease. Am J Clin Pathol. 1962 Jul;38:3–25. doi: 10.1093/ajcp/38.1.3. [DOI] [PubMed] [Google Scholar]
  127. STEINER P. E. Nodular regenerative hyperplasia of the liver. Am J Pathol. 1959 Sep-Oct;35:943–953. [PMC free article] [PubMed] [Google Scholar]
  128. Sakakibapa K., Saito M., Umeda M., Enaka K., Tsukada Y. Native collagen formation by liver parenchymal cells in culture. Nature. 1976 Jul 22;262(5566):316–318. doi: 10.1038/262316a0. [DOI] [PubMed] [Google Scholar]
  129. Sasaki H., Schaffner F., Popper H. Bile ductules in cholestasis: morphologic evidence for secretion and absorption in man. Lab Invest. 1967 Jan;16(1):84–95. [PubMed] [Google Scholar]
  130. Scheuer P. J. Liver biopsy in the diagnosis of cirrhosis. Gut. 1970 Mar;11(3):275–278. doi: 10.1136/gut.11.3.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  131. Schnack H., Stockinger L., Wewalka F. Adventitious connective tissue cells in the space of Disse and their relation to fibre formation. Rev Int Hepatol. 1967;17(8):855–860. [PubMed] [Google Scholar]
  132. Sharp H. L. The current status of alpha-1-antityrpsin, a protease inhibitor, in gastrointestinal disease. Gastroenterology. 1976 Apr;70(4):611–621. [PubMed] [Google Scholar]
  133. Sherlock S. Chronic hepatitis. Gut. 1974 Jul;15(7):581–597. doi: 10.1136/gut.15.7.581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Soloway R. D., Summerskill W. H., Baggenstoss A. H., Schoenfield L. J. "Lupoid" hepatitis, a nonentity in the spectrum of chronic active liver disease. Gastroenterology. 1972 Sep;63(3):458–465. [PubMed] [Google Scholar]
  135. Starzl T. E., Porter K. A., Kashiwagi N. Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration. Surg Gynecol Obstet. 1975 Dec;141(6):843–858. [PMC free article] [PubMed] [Google Scholar]
  136. Sternlieb I., Scheinberg I. H. Radiocopper in diagnosing liver disease. Semin Nucl Med. 1972 Apr;2(2):176–188. doi: 10.1016/s0001-2998(72)80071-0. [DOI] [PubMed] [Google Scholar]
  137. Stone W. D., Islam N. R., Paton A. The natural history of cirrhosis. Experience with an unselected group of patients. Q J Med. 1968 Jan;37(145):119–132. [PubMed] [Google Scholar]
  138. Summerskill W. H. Chronic active liver disease reexamined: prognosis hopeful. Gastroenterology. 1974 Mar;66(3):450–464. [PubMed] [Google Scholar]
  139. Sörensen T. I., Almersjö O. Focal nodular hyperplasia of the liver. Five cases. Scand J Gastroenterol. 1976;11(1):97–101. [PubMed] [Google Scholar]
  140. Takada A., Porta E. A., Hartroft W. S. The recovery of experimental dietary cirrhosis. I. Functional and structural features. Am J Pathol. 1967 Dec;51(6):929–957. [PMC free article] [PubMed] [Google Scholar]
  141. Takada A., Porta E. A., Hartroft W. S. The recovery of experimental dietary cirrhosis. II. Turnover changes of hepatic cells and collagen. Am J Pathol. 1967 Dec;51(6):959–976. [PMC free article] [PubMed] [Google Scholar]
  142. Takahashi T., Tezuka F. Hepatic arteries and arterial circulation in liver cirrhosis. Tohoku J Exp Med. 1974 Jun;113(2):113–128. doi: 10.1620/tjem.113.113. [DOI] [PubMed] [Google Scholar]
  143. WEWALKA F. [Blood groups in liver cirrhosis]. Blut. 1960 Oct;6:261–266. doi: 10.1007/BF01637402. [DOI] [PubMed] [Google Scholar]
  144. Wake K. Development of vitamin A-rich lipid droplets in multivesicular bodies of rat liver stellate cells. J Cell Biol. 1974 Nov;63(2 Pt 1):683–691. doi: 10.1083/jcb.63.2.683. [DOI] [PMC free article] [PubMed] [Google Scholar]
  145. Warren K. S. Hepatosplenic schistosomiasis mansoni: an immunologic disease. Bull N Y Acad Med. 1975 Apr;51(4):545–550. [PMC free article] [PubMed] [Google Scholar]
  146. Weinberg A. G., Mize C. E., Worthen H. G. The occurrence of hepatoma in the chronic form of hereditary tyrosinemia. J Pediatr. 1976 Mar;88(3):434–438. doi: 10.1016/s0022-3476(76)80259-4. [DOI] [PubMed] [Google Scholar]
  147. Weiser M. M., Lamont J. T., Walker W. A. Editorial: Alpha 1-antitrypsin deficiency - a defect of secretion. N Engl J Med. 1975 Jan 23;292(4):205–206. doi: 10.1056/NEJM197501232920410. [DOI] [PubMed] [Google Scholar]
  148. Wiggers K. D., French S. W., French B. A., Carr B. N. The ultrastructure of Mallory body filaments. Lab Invest. 1973 Dec;29(6):652–658. [PubMed] [Google Scholar]
  149. Winkel P., Juhl E., Tygstrup N. The clinical significance of classifications of cirrhosis. A comparison between conventional criteria and numerical taxonomy. Scand J Gastroenterol. 1976;11(1):33–40. [PubMed] [Google Scholar]
  150. Witte M. H., Witte C. L., Dumont A. E. Progress in liver disease: physiological factors involved in the causation of cirrhotic ascites. Gastroenterology. 1971 Nov;61(5):742–750. [PubMed] [Google Scholar]
  151. Zetterman R. K., Luisada-Opper A., Leevy C. M. Alcoholic hepatitis. Cell-mediated immunological response to alcoholic hyalin. Gastroenterology. 1976 Mar;70(3):382–384. [PubMed] [Google Scholar]
  152. Zinneman H. H. Autoimmune phenomena in alcholic cirrhosis. Am J Dig Dis. 1975 Apr;20(4):337–345. doi: 10.1007/BF01237790. [DOI] [PubMed] [Google Scholar]

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