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. 1977 Feb;86(2):375–388.

Murine Type C viral envelope glycoprotein gp69/71 and lupus-like glomerulonephritis of New Zealand mice. An immunoperoxidase study.

M Imamura, R C Mellors, M Strand, J T August
PMCID: PMC2032091  PMID: 189615

Abstract

The location of murine Type C viral envelope glycoprotein antigen in the glomerulonephritic kidneys of NZB and NZB/NZW F1 hybrid mice was analyzed by the indirect immunoperoxidase technique at light and electron microscopic levels. Immune complex deposits of the glycoprotein antigen were present in the glomeruli in mesangial and subepithelial sites. In addition to the glomerular depositions, viral envelope antigen was also present at the brush border of proximal tubular epithelial cells and in lymphoid cells infiltrating the kidneys of these mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Channing A. A., Kasuga T., Horowitz R. E., Dubois E. L., Demopoulos H. B. An ultrastructural study of spontaneous lupus nephritis in the NZB-BL-NZW mouse. Am J Pathol. 1965 Oct;47(4):677–694. [PMC free article] [PubMed] [Google Scholar]
  2. Cochrane C. G., Koffler D. Immune complex disease in experimental animals and man. Adv Immunol. 1973;16(0):185–264. doi: 10.1016/s0065-2776(08)60298-9. [DOI] [PubMed] [Google Scholar]
  3. Davey F. R., Busch G. J. Immunohistochemistry of glomerulonephritis using horseradish peroxidase and fluorescein-labeled antibody: a comparison of two technics. Am J Clin Pathol. 1970 Apr;53(4):531–536. doi: 10.1093/ajcp/53.4.531. [DOI] [PubMed] [Google Scholar]
  4. East J. Immunopathology and neoplasms in New Zealand black (NZB) and SJL-J mice. Prog Exp Tumor Res. 1970;13:84–134. doi: 10.1159/000386038. [DOI] [PubMed] [Google Scholar]
  5. Elias J. M., Miller F. A comparison of the unlabeled enzyme method with immunofluorescence for the evaluation of human immunologic renal disease. Am J Clin Pathol. 1975 Oct;64(4):464–471. doi: 10.1093/ajcp/64.4.464. [DOI] [PubMed] [Google Scholar]
  6. Feenstra K., van den Lee R., Greben H. A., Arends A., Hoedemaeker P. J. Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultrastructural level. Lab Invest. 1975 Feb;32(2):235–242. [PubMed] [Google Scholar]
  7. Howie J. B., Helyer B. J. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–266. doi: 10.1016/s0065-2776(08)60444-7. [DOI] [PubMed] [Google Scholar]
  8. Ikeda H., Pincus T., Yoshiki T., Strand M., August J. T., Boyse E. A., Mellors R. C. Biological expression of antigenic determinants of murine leukemia virus proteins gp69-71 and p30. J Virol. 1974 Nov;14(5):1274–1280. doi: 10.1128/jvi.14.5.1274-1280.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kelley V. E., Cotran R. S. Mesangial and subepithelial localization of ferritin immune complexes in mouse glomerulus. Lab Invest. 1972 Jul;27(1):144–150. [PubMed] [Google Scholar]
  10. Kraehenbuhl J. P., Jamieson J. D. Localization of intracellular antigens by immunoelectron microscopy. Int Rev Exp Pathol. 1974;13(0):1–53. [PubMed] [Google Scholar]
  11. Levy J. A. Autoimmunity and neoplasia. The possible role of C-type viruses. Am J Clin Pathol. 1974 Aug;62(2):258–280. doi: 10.1093/ajcp/62.2.258. [DOI] [PubMed] [Google Scholar]
  12. Mellors R. C., Aoki T., Huebner R. J. Further implication of murine leukemia-like virs in the disorders of NZB mice. J Exp Med. 1969 May 1;129(5):1045–1062. doi: 10.1084/jem.129.5.1045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mellors R. C. Autoimmune and immunoproliferative diseases of NZB/Bl mice and hybrids. Int Rev Exp Pathol. 1966;5:217–252. [PubMed] [Google Scholar]
  14. Mellors R. C., Shirai T., Aoki T., Huebner R. J., Krawczynski K. Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice. J Exp Med. 1971 Jan 1;133(1):113–132. doi: 10.1084/jem.133.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Steeves R. A., Strand M., August J. T. Structural proteins of mammalian oncogenic RNA viruses: murine leukemia virus neutralization by antisera prepared against purified envelope glycoprotein. J Virol. 1974 Jul;14(1):187–189. doi: 10.1128/jvi.14.1.187-189.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Stilmant M. M., Couser W. G., Cotran R. S. Experimental glomerulonephritis in the mouse associated with mesangial deposition ofautologous ferritin immune complexes. Lab Invest. 1975 Jun;32(6):746–756. [PubMed] [Google Scholar]
  17. Strand M., August J. T. Structural proteins of mammalian oncogenic RNA viruses: multiple antigenic determinants of the major internal protein and envelope glycoprotein. J Virol. 1974 Jan;13(1):171–180. doi: 10.1128/jvi.13.1.171-180.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Strand M., August J. T. Structural proteins of oncogenic ribonucleic acid viruses. Interspec II, a new interspecies antigen. J Biol Chem. 1973 Aug 25;248(16):5627–5633. [PubMed] [Google Scholar]
  19. Strand M., August J. T. Structural proteins of ribonucleic acid tumor viruses. Purification of envelope, core, and internal components. J Biol Chem. 1976 Jan 25;251(2):559–564. [PubMed] [Google Scholar]
  20. Yoshiki T., Mellors R. C., Strand M., August J. T. The viral envelope glycoprotein of murine leukemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice. J Exp Med. 1974 Oct 1;140(4):1011–1027. doi: 10.1084/jem.140.4.1011. [DOI] [PMC free article] [PubMed] [Google Scholar]

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