Skip to main content
NCBI home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1977 Aug;88(2):333–344.

The production of migration inhibitory factor and reproductive capacity in allogeneic pregnancies.

J G Tofoski, T J Gill 3rd
PMCID: PMC2032174  PMID: 327826

Abstract

Migration inhibitory factor (MIF) is produced during allogeneic pregnancies but not during syngeneic pregnancies. Removal of the paraaortic or paraaortic and renal lymph nodes significantly decreased MIF production whereas splenectomy did not. Removal of these regional lymph nodes decreased the mean litter size and increased the variance in the weights of the offspring, with the greatest changes occurring when both the paraaortic and renal lymph nodes were removed; splenectomy did not alter either parameter. None of the surgical procedures affected the gestation period significantly, but removal of the paraaortic and renal lymph nodes greatly reduced the rate of conception and increased the incidence of stillbirths. These findings support the proposition that a vigorous immune response occurs during allogeneic pregnancies and that this response provides reproductive advantages to the offspring.

Full text

PDF
333

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIGGERS J. D., CURNOW R. N., FINN C. A., MCLAREN A. REGULATION OF THE GESTATION PERIOD IN MICE. J Reprod Fertil. 1963 Aug;6:125–138. doi: 10.1530/jrf.0.0060125. [DOI] [PubMed] [Google Scholar]
  2. BILLINGHAM R. E., SILVERS W. K. Skin transplants and the hamster. Sci Am. 1963 Jan;208:118–127. doi: 10.1038/scientificamerican0163-118. [DOI] [PubMed] [Google Scholar]
  3. BURWELL R. G. Studies of the primary and the secondary immune responses of lymph nodes draining homografts of fresh cancellous bone (with particular reference to mechanisms of lymph node reactivity). Ann N Y Acad Sci. 1962 Oct 24;99:821–860. doi: 10.1111/j.1749-6632.1962.tb45365.x. [DOI] [PubMed] [Google Scholar]
  4. Beer A. E., Billingham R. E., Scott J. R. Immunogenetic aspects of implantation, placentation and feto-placental growth rates. Biol Reprod. 1975 Feb;12(1):176–189. doi: 10.1095/biolreprod12.1.176. [DOI] [PubMed] [Google Scholar]
  5. Beer A. E., Scott J. R., Billingham R. E. Histoincompatibility and maternal immunological status as determinants of fetoplacental weight and litter size in rodents. J Exp Med. 1975 Jul 1;142(1):180–196. doi: 10.1084/jem.142.1.180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Billingham R. E. The transplantation biology of mammalian gestation. Am J Obstet Gynecol. 1971 Oct 15;111(4):469–483. doi: 10.1016/0002-9378(71)90463-7. [DOI] [PubMed] [Google Scholar]
  7. Billingham R. E. Transplantation immunity evoked by skin homografts and expressed in intact skin. Adv Biol Skin. 1971;11:183–198. [PubMed] [Google Scholar]
  8. Boshier D. P., Moriarty K. M. Some effects on the conceptus of prior immunological sensitization of ewes to the sire. J Reprod Fertil. 1970 Apr;21(3):495–500. doi: 10.1530/jrf.0.0210495. [DOI] [PubMed] [Google Scholar]
  9. Bradford G. E., Nott C. F. Genetic control of ovulation rate and embryo survival in mice. II. Effects of crossing selected lines. Genetics. 1969 Dec;63(4):907–918. doi: 10.1093/genetics/63.4.907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Chai C. K. Effects of inbreeding in rabbits. Inbred lines, discrete characters, breeding performance, and mortality. J Hered. 1969 Mar-Apr;60(2):64–70. doi: 10.1093/oxfordjournals.jhered.a107934. [DOI] [PubMed] [Google Scholar]
  11. Clarke A. G. The effects of maternal pre-immunization on pregnancy in the mouse. J Reprod Fertil. 1971 Mar;24(3):369–375. doi: 10.1530/jrf.0.0240369. [DOI] [PubMed] [Google Scholar]
  12. Cramer D. V., Gill T. J., 3rd Maternal influence on postimplantation survival in inbred rats. J Reprod Fertil. 1975 Aug;44(2):317–321. doi: 10.1530/jrf.0.0440317. [DOI] [PubMed] [Google Scholar]
  13. Finkel S. I., Lilly F. Influence of histoincompatibility between mother and foetus on placental size in mice. Nature. 1971 Nov 12;234(5324):102–103. doi: 10.1038/234102a0. [DOI] [PubMed] [Google Scholar]
  14. Goodman H. S., Masaitis L. Analysis of the isoimmune response to leucocytes: I. Maternal cytotoxic response to fetal lymphocytes. Proc Soc Exp Biol Med. 1967 Nov;126(2):599–604. doi: 10.3181/00379727-126-32517. [DOI] [PubMed] [Google Scholar]
  15. HERZENBERG L. A., GONZALES B. Appearance of H-2 agglutinins in outcrossed female mice. Proc Natl Acad Sci U S A. 1962 Apr 15;48:570–573. doi: 10.1073/pnas.48.4.570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hellström K. E., Hellström I., Brawn J. Abrogation of cellular immunity to antigenically foreign mouse embryonic cells by a serum factor. Nature. 1969 Nov 29;224(5222):914–915. doi: 10.1038/224914a0. [DOI] [PubMed] [Google Scholar]
  17. Hetherington C. M. The decidual cell reaction, placental weight, foetal weight and placental morphology in the mouse. J Reprod Fertil. 1971 Jun;25(3):417–424. doi: 10.1530/jrf.0.0250417. [DOI] [PubMed] [Google Scholar]
  18. James D. A. Some effects of immunological factors on gestation in mice. J Reprod Fertil. 1967 Oct;14(2):265–275. doi: 10.1530/jrf.0.0140265. [DOI] [PubMed] [Google Scholar]
  19. KALISS N., DAGG M. K. IMMUNE RESPONSE ENGENDERED IN MICE BY MULTIPARITY. Transplantation. 1964 May;2:416–425. doi: 10.1097/00007890-196405000-00011. [DOI] [PubMed] [Google Scholar]
  20. MCCARTHY J. C. THE EFFECT OF LITTER SIZE OF CROSSING INBRED STRAINS OF MICE. Genetics. 1965 Feb;51:217–222. doi: 10.1093/genetics/51.2.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. MCLAREN A., MICHIE D. NATURE OF THE SYSTEMIC EFFECT OF LITTER SIZE ON GESTATION PERIOD IN MICE. J Reprod Fertil. 1963 Aug;6:139–141. doi: 10.1530/jrf.0.0060139. [DOI] [PubMed] [Google Scholar]
  22. MISHELL R. I., HERZENBERG L. A., HERZENBERG L. A. LEUKOCYTE AGGLUTINATION IN MICE; DETECTION OF H-2 AND NON-H-2 ISOANTIGENS. J Immunol. 1963 Apr;90:628–633. [PubMed] [Google Scholar]
  23. Mantalenakis S. J., Danezis J. M. Effect of blastocyst transfer on gestation period in rats. Fertil Steril. 1968 Nov-Dec;19(6):910–913. doi: 10.1016/s0015-0282(16)36845-5. [DOI] [PubMed] [Google Scholar]
  24. Maroni E. S., Parrott D. M. Progressive increase in cell-mediated immunity against paternal transplantation antigens in parous mice after multiple pregnancies. Clin Exp Immunol. 1973 Feb;13(2):253–262. [PMC free article] [PubMed] [Google Scholar]
  25. Maroni E. S., de Sousa M. A. The lymphoid organs during pregnancy in the mouse. A comparison between a syngeneic and an allogeneic mating. Clin Exp Immunol. 1973 Jan;13(1):107–124. [PMC free article] [PubMed] [Google Scholar]
  26. McLean J. M., Mosley J. G., Gibbs A. C. Changes in the thymus, spleen and lymph nodes during pregnancy and lactation in the rat. J Anat. 1974 Nov;118(Pt 2):223–229. [PMC free article] [PubMed] [Google Scholar]
  27. McLean J. M., Scothorne R. J. The fate of skin allografts in the rabbit uterus. J Anat. 1972 Sep;112(Pt 3):423–432. [PMC free article] [PubMed] [Google Scholar]
  28. McLean J. M., Scothorne R. J. The lymphatics of the endometrium in the rabbit. J Anat. 1970 Jul;107(Pt 1):39–48. [PMC free article] [PubMed] [Google Scholar]
  29. OLIN T., SALDEEN T. THE LYMPHATIC PATHWAYS FROM THE PERITONEAL CAVITY: A LYMPHANGIOGRAPHIC STUDY IN THE RAT. Cancer Res. 1964 Nov;24:1700–1711. [PubMed] [Google Scholar]
  30. Overweg J., Engelfriet C. P. Cytotoxic leucocyte iso-antibodies formed during the first pregnancy. Vox Sang. 1969 Feb;16(2):97–104. doi: 10.1111/j.1423-0410.1969.tb04722.x. [DOI] [PubMed] [Google Scholar]
  31. PAYNE R. The development and persistence of leukoagglutinins in parous women. Blood. 1962 Apr;19:411–424. [PubMed] [Google Scholar]
  32. Ruscetti S. K., Gill T. J., 3rd, Salvin S. B., Herrman J., Bailie C. W. Production of migration inhibitory factor in inbred rats. Int Arch Allergy Appl Immunol. 1976;52(1-4):417–421. doi: 10.1159/000231710. [DOI] [PubMed] [Google Scholar]
  33. SCOTHORNE R. J., MCGREGOR I. A. Cellular changes in lymph nodes and spleen following skin homografting in the rabbit. J Anat. 1955 Jul;89(3):283–292. [PMC free article] [PubMed] [Google Scholar]
  34. Sörén L. Immunological reactivity of lymphocytes in multiparous females after strain specific matings. Nature. 1967 Feb 11;213(5076):621–622. doi: 10.1038/213621a0. [DOI] [PubMed] [Google Scholar]
  35. Tilney N. L. Patterns of lymphatic drainage in the adult laboratory rat. J Anat. 1971 Sep;109(Pt 3):369–383. [PMC free article] [PubMed] [Google Scholar]
  36. Tissot R. G., Cohen C. Histocompatibility in the rabbit. Identification of the major locus. Tissue Antigens. 1972;2(3):267–279. [PubMed] [Google Scholar]
  37. Tyler W. J., Chapman A. B. Genetically Reduced Prolificacy in Rats. Genetics. 1948 Nov;33(6):565–576. doi: 10.1093/genetics/33.6.565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. VAN ROOD J. J., EERNISSE J. G., VAN LEEUWEN A. Leucocyte antibodies in sera from pregnant women. Nature. 1958 Jun 21;181(4625):1735–1736. doi: 10.1038/1811735a0. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES