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. 1975 Nov;81(2):379–387.

Clonal characteristics of fibrous plaques and fatty streaks from human aortas.

T A Pearson, B A Wang, K Solez, R H Heptinstall
PMCID: PMC2032205  PMID: 1190295

Abstract

Using isoenzymes of glucose-6-phosphate dehydrogenase (G-6-PD) as cellular markers, a study was made of atherosclerotic fibrous plaques and fatty streaks in aortas of black women heterozygous for G-6-PD. Of 29 fibrous plaques, 26 (89.7%) contained only one isoenzyme (17, A; 9, B), the other three containing both A and B. Of 28 fatty streaks, five (17.8%) contained only one isoenzyme (2, A; 3, B), the remaining 23 containing both A and B. Normal uninvolved aorta contained both A and B isoenzymes in 99 of 101 samples. These results confirm the monoclonal character of atherosclerotic fibrous plaques; this strands in contrast to the fatty streaks which most commonly contain the two isoenzymes. The studies on the fatty streaks are inconclusive at this stage in determining whether the streak is the forerunner of the fibrous plaque.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALIS J. U., HAUST M. D., MORE R. H. ELECTRON-MICROSCOPIC STUDIES IN HUMAN ATHEROSCLEROSIS; CELLULAR ELEMENTS IN AORTIC FATTY STREAKS. Exp Mol Pathol. 1964 Oct;90:511–525. doi: 10.1016/0014-4800(64)90031-0. [DOI] [PubMed] [Google Scholar]
  2. BEUTLER E., YEH M., FAIRBANKS V. F. The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker. Proc Natl Acad Sci U S A. 1962 Jan 15;48:9–16. doi: 10.1073/pnas.48.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Benditt E. P., Benditt J. M. Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci U S A. 1973 Jun;70(6):1753–1756. doi: 10.1073/pnas.70.6.1753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Benditt E. P. Evidence for a monoclonal origin of human atherosclerotic plaques and some implications. Circulation. 1974 Oct;50(4):650–652. doi: 10.1161/01.cir.50.4.650. [DOI] [PubMed] [Google Scholar]
  5. DAVIDSON R. G., NITOWSKY H. M., CHILDS B. DEMONSTRATION OF TWO POPULATIONS OF CELLS IN THE HUMAN FEMALE HETEROZYGOUS FOR GLUCOSE-6-PHOSPHATE DEHYDROGENASE VARIANTS. Proc Natl Acad Sci U S A. 1963 Sep;50:481–485. doi: 10.1073/pnas.50.3.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fialkow P. J. The origin and development of human tumors studied with cell markers. N Engl J Med. 1974 Jul 4;291(1):26–35. doi: 10.1056/NEJM197407042910109. [DOI] [PubMed] [Google Scholar]
  7. Geer J. C. Fine structure of human aortic intimal thickening and fatty streaks. Lab Invest. 1965 Oct;14(10):1764–1783. [PubMed] [Google Scholar]
  8. HOLMAN R. L., McGILL H. C., Jr, STRONG J. P., GEER J. C. The natural history of atherosclerosis: the early aortic lesions as seen in New Orleans in the middle of the of the 20th century. Am J Pathol. 1958 Mar-Apr;34(2):209–235. [PMC free article] [PubMed] [Google Scholar]
  9. LYON M. F. Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature. 1961 Apr 22;190:372–373. doi: 10.1038/190372a0. [DOI] [PubMed] [Google Scholar]
  10. Linder D., Gartler S. M. Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas. Science. 1965 Oct 1;150(3692):67–69. doi: 10.1126/science.150.3692.67. [DOI] [PubMed] [Google Scholar]
  11. McGill H. C., Jr Fatty streaks in the coronary arteries and aorta. Lab Invest. 1968 May;18(5):560–564. [PubMed] [Google Scholar]
  12. Ross R., Glomset J. A. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973 Jun 29;180(4093):1332–1339. doi: 10.1126/science.180.4093.1332. [DOI] [PubMed] [Google Scholar]
  13. SCHWARTZ C. J., MITCHELL J. R. Observations on localization of arterial plaques. Circ Res. 1962 Jul;11:63–73. [PubMed] [Google Scholar]
  14. Smith E. B., Slater R. S. The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis. 1. The lipids in the isolated fractions. Atherosclerosis. 1972 Jan-Feb;15(1):37–56. doi: 10.1016/0021-9150(72)90036-6. [DOI] [PubMed] [Google Scholar]
  15. Sparkes R. S., Baluda M. C., Townsend D. E. Cellulose acetate electrophoresis of human glucose-6-phosphate dehydrogenase. J Lab Clin Med. 1969 Mar;73(3):531–534. [PubMed] [Google Scholar]
  16. Yoshida A. Glucose 6-phosphate dehydrogenase of human erythrocytes. I. Purification and characterization of normal (B+) enzyme. J Biol Chem. 1966 Nov 10;241(21):4966–4976. [PubMed] [Google Scholar]

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