Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1977 Sep;88(3):711–725.

Clinical conditions associated with defective polymorphonuclear leukocyte chemotaxis.

P G Quie, K L Cates
PMCID: PMC2032383  PMID: 407800

Abstract

Impressive numbers of clinical conditions are associated with defective leukocyte chemotaxis. In many, this cellular dysfunction is associated with other abnormalities of the immune response, but in others abnormal chemotactic responsiveness of leukocytes is the only abnormality of function identified in the laboratory. Patients are usually selected for study because of unusually severe, recurrent infections or poor response to antimicrobial agents, and therefore a frequent association between abnormality of chemotaxis and infection would be expected. Many patients demonstrate abnormal chemotaxis during remissions as well as during infections, and there seems little doubt that abnormality of chemotaxis is related to susceptibility to infections. Partial classification of disorders of chemotaxis was attempted. Major abnormalities are found when there is a primary cellular disorder or cell-directed inhibitors of chemotaxis are found. Less marked abnormalities are found when chemotactic factors are deficient.

Full text

PDF
711

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altman L. C., Snyderman R., Blaese R. M. Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. J Clin Invest. 1974 Aug;54(2):486–493. doi: 10.1172/JCI107784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson R., Sher R., Rabson A. R., Koornhof H. J. Letter: Defective chemotaxis in measles patients. S Afr Med J. 1974 Sep 7;48(43):1819–1820. [PubMed] [Google Scholar]
  3. Ballow M., Shira J. E., Harden L., Yang S. Y., Day N. K. Complete absence of the third component of complement in man. J Clin Invest. 1975 Sep;56(3):703–710. doi: 10.1172/JCI108141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Björkstén B., Lundmark K. M. Recurrent bacterial infections in four siblings with neutropenia, eosinophilia, hyperimmunoglobulinemia A, and defective neutrophil chemotaxis. J Infect Dis. 1976 Jan;133(1):63–71. doi: 10.1093/infdis/133.1.63. [DOI] [PubMed] [Google Scholar]
  5. Boxer L. A., Hedley-Whyte E. T., Stossel T. P. Neutrophil action dysfunction and abnormal neutrophil behavior. N Engl J Med. 1974 Nov 21;291(21):1093–1099. doi: 10.1056/NEJM197411212912101. [DOI] [PubMed] [Google Scholar]
  6. Boxer L. A., Watanabe A. M., Rister M., Besch H. R., Jr, Allen J., Baehner R. L. Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. N Engl J Med. 1976 Nov 4;295(19):1041–1045. doi: 10.1056/NEJM197611042951904. [DOI] [PubMed] [Google Scholar]
  7. Boyer J. T., Gall E. P., Norman M. E., Nilsson U. R., Zimmerman T. S. Hereditary deficiency of the seventh component of complement. J Clin Invest. 1975 Oct;56(4):905–913. doi: 10.1172/JCI108170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Clark R. A., Johnson F. L., Klebanoff S. J., Thomas E. D. Defective neutrophil chemotaxis in bone marrow transplant patients. J Clin Invest. 1976 Jul;58(1):22–31. doi: 10.1172/JCI108452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Clark R. A., Kimball H. R. Defective granulocyte chemotaxis in the Chediak-Higashi syndrome. J Clin Invest. 1971 Dec;50(12):2645–2652. doi: 10.1172/JCI106765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Clark R. A., Root R. K., Kimball H. R., Kirkpatrick C. H. Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections. Ann Intern Med. 1973 Apr;78(4):515–519. doi: 10.7326/0003-4819-78-4-515. [DOI] [PubMed] [Google Scholar]
  11. Dahl M. V., Greene W. H., Jr, Quie P. G. Infection, dermatitis, increased IgE, and impaired neutrophil chemotaxis. A possible relationship. Arch Dermatol. 1976 Oct;112(10):1387–1390. [PubMed] [Google Scholar]
  12. DeMeo A. N., Andersen B. R. Defective chemotaxis associated with a serum inhibitor in cirrhotic patients. N Engl J Med. 1972 Apr 6;286(14):735–740. doi: 10.1056/NEJM197204062861401. [DOI] [PubMed] [Google Scholar]
  13. Desnick R. J., Sharp H. L., Grabowski G. A., Brunning R. D., Quie P. G., Sung J. H., Gorlin R. J., Ikonne J. U. Mannosidosis: clinical, morphologic, immunologic, and biochemical studies. Pediatr Res. 1976 Dec;10(12):985–996. doi: 10.1203/00006450-197612000-00008. [DOI] [PubMed] [Google Scholar]
  14. Greene W. H., Ray C., Mauer S. M., Quie P. G. The effect of hemodialysis on neutrophil chemotactic responsiveness. J Lab Clin Med. 1976 Dec;88(6):971–974. [PubMed] [Google Scholar]
  15. Hill H. R., Gerrard J. M., Hogan N. A., Quie P. G. Hyperactivity of neutrophil leukotactic responses during active bacterial infection. J Clin Invest. 1974 Apr;53(4):996–1002. doi: 10.1172/JCI107666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hill H. R., Ochs H. D., Quie P. G., Clark R. A., Pabst H. F., Klebanoff S. J., Wedgwood R. J. Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent "cold" staphylococcal abscesses. Lancet. 1974 Sep 14;2(7881):617–619. doi: 10.1016/s0140-6736(74)91942-4. [DOI] [PubMed] [Google Scholar]
  17. Hill H. R., Quie P. G. Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet. 1974 Feb 9;1(7850):183–187. doi: 10.1016/s0140-6736(74)92493-3. [DOI] [PubMed] [Google Scholar]
  18. Hill H. R., Sauls H. S., Dettloff J. L., Quie P. G. Impaired leukotactic responsiveness in patients with juvenile diabetes mellitus. Clin Immunol Immunopathol. 1974 Apr;2(3):395–403. doi: 10.1016/0090-1229(74)90057-9. [DOI] [PubMed] [Google Scholar]
  19. Hill H. R., Williams P. B., Krueger G. G., Janis B. Recurrent staphylococcal abscesses associated with defective neutrophil chemotaxis and allergic rhinitis. Ann Intern Med. 1976 Jul;85(1):39–43. doi: 10.7326/0003-4819-85-1-39. [DOI] [PubMed] [Google Scholar]
  20. Kelly M. T., White A. Histamine release induced by human leukocyte lysates. Reabsorption of previously released histamine after exposure to cyclic amp-active agents. J Clin Invest. 1973 Aug;52(8):1834–1840. doi: 10.1172/JCI107365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Maderazo E. G., Ward P. A., Woronick C. L., Kubik J., DeGraff A. C., Jr Leukotactic dystunction in sarcoidosis. Ann Intern Med. 1976 Apr;84(4):414–419. doi: 10.7326/0003-4819-84-4-414. [DOI] [PubMed] [Google Scholar]
  22. McCall C. E., Caves J., Cooper R., DeChatlet L. Functional characteristics of human toxic neutrophils. J Infect Dis. 1971 Jul;124(1):68–75. doi: 10.1093/infdis/124.1.68. [DOI] [PubMed] [Google Scholar]
  23. Miller M. E., Nilsson U. R. A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5). N Engl J Med. 1970 Feb 12;282(7):354–358. doi: 10.1056/NEJM197002122820702. [DOI] [PubMed] [Google Scholar]
  24. Miller M. E., Norman M. E., Koblenzer P. J., Schonauer T. A new familial defect of neutrophil movement. J Lab Clin Med. 1973 Jul;82(1):1–8. [PubMed] [Google Scholar]
  25. Miller M. E., Oski F. A., Harris M. B. Lazy-leucocyte syndrome. A new disorder of neutrophil function. Lancet. 1971 Apr 3;1(7701):665–669. doi: 10.1016/s0140-6736(71)92679-1. [DOI] [PubMed] [Google Scholar]
  26. Molenaar D. M., Palumbo P. J., Wilson W. R., Ritts R. E., Jr Leukocyte chemotaxis in diabetic patients and their nondiabetic first-degree relatives. Diabetes. 1976;25(2 Suppl):880–883. [PubMed] [Google Scholar]
  27. Mowat A., Baum J. Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus. N Engl J Med. 1971 Mar 25;284(12):621–627. doi: 10.1056/NEJM197103252841201. [DOI] [PubMed] [Google Scholar]
  28. Orlowski J. P., Sieger L., Anthony B. F. Bactericidal capacity of monocytes of newborn infants. J Pediatr. 1976 Nov;89(5):797–801. doi: 10.1016/s0022-3476(76)80810-4. [DOI] [PubMed] [Google Scholar]
  29. Pincus S. H., Thomas I. T., Clark R. A., Ochs H. D. Defective neutrophil chemotaxis with variant ichthyosis, hyperimmunoglobulinemia E, and recurrent infections. J Pediatr. 1975 Dec;87(6 Pt 1):908–911. doi: 10.1016/s0022-3476(75)80903-6. [DOI] [PubMed] [Google Scholar]
  30. Rogge J. L., Hanifin J. M. Immunodeficiencies in severe atopic dermatitis. Depressed chemotaxis and lymphocyte transformation. Arch Dermatol. 1976 Oct;112(10):1391–1396. [PubMed] [Google Scholar]
  31. Rosenfeld S. I., Kelly M. E., Leddy J. P. Hereditary deficiency of the fifth component of complement in man. I. Clinical, immunochemical, and family studies. J Clin Invest. 1976 Jun;57(6):1626–1634. doi: 10.1172/JCI108433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Ruddy S., Gigli I., Austen K. F. The complement system of man. 3. N Engl J Med. 1972 Sep 21;287(12):592–596. doi: 10.1056/NEJM197209212871206. [DOI] [PubMed] [Google Scholar]
  33. Schopfer K., Douglas S. D. Neutrophil function in children with kwashiorkor. J Lab Clin Med. 1976 Sep;88(3):450–461. [PubMed] [Google Scholar]
  34. Singh H., Boyd E., Hutton M. M., Wilkinson P. C., Brown D. A., Ferguson-Smith M. A. Chromosomal mutation in bone-marrow as cause of acquired granulomatous disease and refractory macrocytic anaemia. Lancet. 1972 Apr 22;1(7756):873–879. doi: 10.1016/s0140-6736(72)90741-6. [DOI] [PubMed] [Google Scholar]
  35. Steerman R. L., Snyderman R., Leikin S. L., Colten H. R. Instrinsic defect of the polymorphonuclear leucocyte resulting in impaired chemotaxis and phagocytosis. Clin Exp Immunol. 1971 Dec;9(6):939–946. [PMC free article] [PubMed] [Google Scholar]
  36. Van Epps D. E., Palmer D. L., Williams R. C., Jr Characterization of serum inhibitors of neutrophil chemotaxis associated with anergy. J Immunol. 1974 Jul;113(1):189–200. [PubMed] [Google Scholar]
  37. Van Epps D. E., Williams R. C., Jr Suppression of leukocyte chemotaxis by human IgA myeloma components. J Exp Med. 1976 Nov 2;144(5):1227–1242. doi: 10.1084/jem.144.5.1227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Van Scoy R. E., Hill H. R., Ritts R. E., Quie P. G. Familial neutrophil chemotaxis defect, recurrent bacterial infections, mucocutaneous candidiasis, and hyperimmunoglobulinemia E. Ann Intern Med. 1975 Jun;82(6):766–771. doi: 10.7326/0003-4819-82-6-766. [DOI] [PubMed] [Google Scholar]
  39. Ward P. A., Goralnick S., Bullock W. E. Defective leukotaxis in patients with lepromatous leprosy. J Lab Clin Med. 1976 Jun;87(6):1025–1032. [PubMed] [Google Scholar]
  40. Ward P. A., Schlegel R. J. Impaired leucotactic responsiveness in a child with recurrent infections. Lancet. 1969 Aug 16;2(7616):344–347. doi: 10.1016/s0140-6736(69)92699-3. [DOI] [PubMed] [Google Scholar]
  41. Wellek B., Opferkuch W. A case of deficiency of the seventh component of complement in man. Biological properties of a C7-deficient serum and description of a C7-inactivating principle. Clin Exp Immunol. 1975 Feb;19(2):223–235. [PMC free article] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES