Abstract
Rabbits were immunized with intestinal antigens derived from rabbits, guinea pigs, and germfree rats. Inflammatory changes throughout the portal tracts of the liver were found in 55% (16 of 29) of the immunized rabbits. Interstitial nephritis was present in 7 of 23 rabbits evaluated. These changes did not occur when nonintestinal antigens were used for immunization. Antigen shared by liver, kidney, duodenum, ileum, and colon were found in each of the species used for immunization. An immune response to the antigen shared by the various tissues may be a factor in the pathogenesis of disease in this experimental system. In man, chronic active hepatitis and interstitial nephritis are found in association with inflammatory bowel disease. A similar mechanism of pathogenesis may be a factor in these extraintestinal manifestations of inflammatory bowel disease in man.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blackwell J. B. The effects on the liver of sensitised rats of intravenous injection of antigen. J Pathol Bacteriol. 1965 Jul;90(1):259–268. doi: 10.1002/path.1700900128. [DOI] [PubMed] [Google Scholar]
- Büschenfelde K. H., Kössling F. K., Miescher P. A. Experimental chronic active hepatitis in rabbits following immunization with human liver proteins. Clin Exp Immunol. 1972 May;11(1):99–108. [PMC free article] [PubMed] [Google Scholar]
- Golding P. L., Mason A. S. Renal tubular acidosis and autoimmune liver disease. Gut. 1971 Feb;12(2):153–157. doi: 10.1136/gut.12.2.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Golding P. L., Smith M., Williams R. Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis. Am J Med. 1973 Dec;55(6):772–782. doi: 10.1016/0002-9343(73)90258-1. [DOI] [PubMed] [Google Scholar]
- Paronetto F., Schaffner F., Popper H. Antibodies to cytoplasmic antigens in primary biliary cirrhosis and chronic active hepatitis. J Lab Clin Med. 1967 Jun;69(6):979–988. [PubMed] [Google Scholar]
- Plotz P. H. Autoimmunity in hepatitis. Med Clin North Am. 1975 Jul;59(4):869–876. doi: 10.1016/s0025-7125(16)31985-x. [DOI] [PubMed] [Google Scholar]
- Rabin B. S. Duodenum-, ileum- and colon-specific antigens. Int Arch Allergy Appl Immunol. 1976;50(2):133–141. doi: 10.1159/000231490. [DOI] [PubMed] [Google Scholar]
- Rabin B. S., Rogers S. J. Nonpathogenicity of antiintestinal antibody in the rabbit. Am J Pathol. 1976 May;83(2):269–282. [PMC free article] [PubMed] [Google Scholar]
- Redeker A. G. Chronic hepatitis. Med Clin North Am. 1975 Jul;59(4):863–867. doi: 10.1016/s0025-7125(16)31984-8. [DOI] [PubMed] [Google Scholar]
- Smith M. G., Eddleston A. L., Williams R. Immunological factors in the evolution of active chronic hepatitis and other autoimmune liver diseases. Clin Gastroenterol. 1975 May;4(2):297–313. [PubMed] [Google Scholar]
- Tsantoulas D. C., McFarlane I. G., Portmann B., Eddleston A. L., Williams R. Cell-mediated immunity to human Tamm-Horsfall glycoprotein in autoimmune liver disease with renal tubular acidosis. Br Med J. 1974 Nov 30;4(5943):491–494. doi: 10.1136/bmj.4.5943.491. [DOI] [PMC free article] [PubMed] [Google Scholar]