Studies in the Diabetic Mutant Mouse

Abstract

Light and electron microscopic studies were performed on renal glomeruli of diabetic mutant and age-matched normal mice and correlated with alterations in urinary excretion. The glomeruli of young (prediabetic) mutants and their normal littermates were normal and identical. With increasing age, the glomeruli of normal control mice were characterized by mesangial prominence and increased thickness and nodular densities of the peripheral basal lamina. These alterations were also observed in the diabetic mutant mice but more frequently and to a greatly exaggerated degree. The diabetic mutants were polyuric and excreted a quantity of protein identified by agarose and inmunoelectrophoresis as a serum protein. The excretion of this protein preceded the recognition of the morphologic alterations and did not increase in magnitude with the progression of glomerular changes. This report challenges the theoretic concept of genetically controlled diabetic glomerular lesions and discusses possible relationships between the glomerular alterations, the presence of proteinuria and the presence of hyperglycemia.

Full text

PDF

• 193
• 194
• 195
• 196
• 197
• …
• 224
• Next

Images in this article

Fig 9
on p.210

Fig 10
on p.211

Fig 19
on p.220

Fig 11
on p.212

Fig 20
on p.221

Fig 12
on p.213

Fig 21
on p.222

Fig 1
on p.205

Fig 2
on p.205

Fig 22
on p.223

Figs 3 and 4
on p.206

Fig 13
on p.215

Fig 14
on p.215

Fig 23
on p.224

Fig 5
on p.207

Fig 6
on p.207

Fig 15
on p.216

Fig 7
on p.208

Fig 16
on p.217

Fig 8
on p.209

Fig 17
on p.218

Fig 18
on p.219