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. 1976 Nov;85(2):373–382.

Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice.

E S Kleinerman, C A Daniels, R P Polisson, R Snyderman
PMCID: PMC2032573  PMID: 11695

Abstract

To better define the mechanisms by which viruses depress immune function, the effect of influenza infection on the ability of macrophages to accumulate at sites of inflammation was determined. Mice were inoculated with virus, and their inflammatory response measured in vivo by counting the number of leukocytes which accumulated in the peritoneal cavity 2 days after an intraperitoneal injection of phytohemagglutinin. Mice infected with influenza had a 57% and 65% depression of total leukocyte and macrophage accumulation, respectively, as compared to the response of uninfected mice. In contrast, bacterial pneumonia did not produce a decrease in the macrophage response. This indicated that the depression was produced by the virus infection rather than being a nonspecific phenomenon accompanying any inflammatory focus in the lung. The in vitro chemotactic responsiveness of normal peritoneal macrophages incubated with infectious influenza virus was 53% of normal. These experiments suggest that influenza infection may depress a host's ability to mobilize macrophages to inflammatory sites in vivo by inhibiting their chemotactic responsiveness.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altman L. C., Snyderman R., Blaese R. M. Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. J Clin Invest. 1974 Aug;54(2):486–493. doi: 10.1172/JCI107784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boetcher D. A., Leonard E. J. Abnormal monocyte chemotactic response in cancer patients. J Natl Cancer Inst. 1974 Apr;52(4):1091–1099. doi: 10.1093/jnci/52.4.1091. [DOI] [PubMed] [Google Scholar]
  3. Dent P. B. Immunodepression by oncogenic viruses. Prog Med Virol. 1972;14:1–35. [PubMed] [Google Scholar]
  4. HENLE W., LIEF F. S. Studies on the soluble antigen of influenza virus. I. The release of S antigen from elementary bodies by treatment with ether. Virology. 1956 Dec;2(6):753–771. doi: 10.1016/0042-6822(56)90056-3. [DOI] [PubMed] [Google Scholar]
  5. Hill H. R., Gerrard J. M., Hogan N. A., Quie P. G. Hyperactivity of neutrophil leukotactic responses during active bacterial infection. J Clin Invest. 1974 Apr;53(4):996–1002. doi: 10.1172/JCI107666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jennings R., Potter C. W., McLaren C. Effect of preinfection and preimmunization on the serum antibody response to subsequent immunization with heterotypic influenza vaccines. J Immunol. 1974 Dec;113(6):1834–1843. [PubMed] [Google Scholar]
  7. Kantzler G. B., Lauteria S. F., Cusumano C. L., Lee J. D., Ganguly R., Waldman R. H. Immunosuppression during influenza virus infection. Infect Immun. 1974 Nov;10(5):996–1002. doi: 10.1128/iai.10.5.996-1002.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kleinerman E. S., Snyderman R., Daniels C. A. Depressed monocyte chemotaxis during acute influenza infection. Lancet. 1975 Nov 29;2(7944):1063–1066. doi: 10.1016/s0140-6736(75)90432-8. [DOI] [PubMed] [Google Scholar]
  9. Kleinerman E. S., Snyderman R., Daniels C. A. Depression of human monocyte chemotaxis by herpes simplex and influenza viruses. J Immunol. 1974 Nov;113(5):1562–1567. [PubMed] [Google Scholar]
  10. MARTIN C. M., KUNIN C. M., GOTTLIEB L. S., FINLAND M. Asian influenza A in Boston, 1957-1958. II. Severe staphylococcal pneumonia complicating influenza. AMA Arch Intern Med. 1959 Apr;103(4):532–542. doi: 10.1001/archinte.1959.00270040018002. [DOI] [PubMed] [Google Scholar]
  11. Mortensen R. F., Ceglowski W. S., Friedman H. In vitro assessment of cellular immunity to Rauscher leukemia virus. J Immunol. 1973 Sep;111(3):657–660. [PubMed] [Google Scholar]
  12. Notkins A. L., Mergenhagen S. E., Howard R. J. Effect of virus infections on the function of the immune system. Annu Rev Microbiol. 1970;24:525–538. doi: 10.1146/annurev.mi.24.100170.002521. [DOI] [PubMed] [Google Scholar]
  13. Reed W. P., Olds J. W., Kisch A. L. Decreased skin-test reactivity associated with influenza. J Infect Dis. 1972 Apr;125(4):398–402. doi: 10.1093/infdis/125.4.398. [DOI] [PubMed] [Google Scholar]
  14. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  15. Snyderman R., Altman L. C., Frankel A., Blaese R. M. Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. Ann Intern Med. 1973 Apr;78(4):509–513. doi: 10.7326/0003-4819-78-4-509. [DOI] [PubMed] [Google Scholar]
  16. Snyderman R., Phillips J. K., Mergenhagen S. E. Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. J Exp Med. 1971 Nov 1;134(5):1131–1143. doi: 10.1084/jem.134.5.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Snyderman R., Pike M. C., Blaylock B. L., Weinstein P. Effects of neoplasms on inflammation: depression of macrophage accumulation after tumor implantation. J Immunol. 1976 Mar;116(3):585–589. [PubMed] [Google Scholar]
  18. Snyderman R., Pike M. C., McCarley D., Lang L. Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity. Infect Immun. 1975 Mar;11(3):488–492. doi: 10.1128/iai.11.3.488-492.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Willems F. T., Melnick J. L., Rawls W. E. Viral inhibition of the phytohemagglutinin response of human lymphocytes and application to viral hepatitis. Proc Soc Exp Biol Med. 1969 Feb;130(2):652–661. doi: 10.3181/00379727-130-33628. [DOI] [PubMed] [Google Scholar]

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