Abstract
The origin of the alveolar macrophage was studied in cultured explants of murine lung. In this system, which is free of circulating monocytes, a new population of alveolar macrophages was identified on the third day of culture; immediately preceding the appearance of these cells, proliferation of pulmonary interstitial cells was observed. A temporal relationship between interstitial cells and alveolar macrophages was established by autoradiographic studies; evidence is advanced which favors the direct migration of interstitial cells into alveoli. It is concluded that the pulmonary interstitium constitutes an intermediate compartment between the blood monocyte and the alveolar macrophage.
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