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. 1994 Jul;70(1):42–47. doi: 10.1038/bjc.1994.247

Characteristic karyotypic features in lacrimal and salivary gland carcinomas.

Y Jin 1, F Mertens 1, J Limon 1, N Mandahl 1, J Wennerberg 1, M Dictor 1, S Heim 1, F Mitelman 1
PMCID: PMC2033313  PMID: 8018539

Abstract

Short-term cultures from 12 non-squamous cell carcinomas (NSCCs) of the head and neck were cytogenetically investigated. Three tumours were acinic cell carcinomas, two adenoid cystic carcinomas, three mucoepidermoid carcinomas, two carcinomas in pleomorphic adenoma, and two adenocarcinomas. Clonal chromosome aberrations were detected in all but one adenocarcinoma. Including our data, a total of 40 head and neck NSCCs with clonal aberrations have been described. Deletions of the long arm of chromosome 6 are the most common aberrations (11/40 cases); they have been detected in all types of NSCC except carcinoma in pleomorphic adenoma. Two aberrations seem to be closely associated with tumour type: t(6;9)(q21-24;p13-23), which has been seen in three of 11 adenoid cystic carcinomas (in two as the sole aberration), and structural rearrangements of 8q12-13, which have been detected in three of four carcinomas in pleomorphic adenoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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