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. 1994 Oct;70(4):690–693. doi: 10.1038/bjc.1994.374

Clinical features of hepatocellular carcinoma in the elderly: a study of 91 patients older than 70 years.

F Nomura 1, K Ohnishi 1, M Honda 1, Y Satomura 1, T Nakai 1, K Okuda 1
PMCID: PMC2033406  PMID: 7917919

Abstract

In order to determine the clinical features of hepatocellular carcinoma in the elderly, a total of 622 patients with hepatocellular carcinoma, including 91 patients 70 years or older, were retrospectively analysed with reference to their ages at the time of diagnosis. The proportion of females increased and that of hepatitis B surface antigen-positive cases decreased as age increased. Tumour sizes at the time of diagnosis were somewhat smaller in the elderly than in younger patients, whereas clinical stage taking liver function into consideration was similar in the two age groups. The prognosis in the elderly patients was similar to that in the younger ones in a clinical stage-matched comparison. Furthermore, by a multivariate analysis using the Cox proportional hazards model with inclusion of age and other clinical parameters, age was not selected in the final model as an independent predictor for survival. These results indicate that elderly patients with hepatocellular carcinoma have certain clinical features different from those in younger patients and that their prognosis is not necessarily poorer than in the latter.

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Selected References

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  1. Calvet X., Bruix J., Ginés P., Bru C., Solé M., Vilana R., Rodés J. Prognostic factors of hepatocellular carcinoma in the west: a multivariate analysis in 206 patients. Hepatology. 1990 Oct;12(4 Pt 1):753–760. doi: 10.1002/hep.1840120422. [DOI] [PubMed] [Google Scholar]
  2. Castells A., Bruix J., Bru C., Fuster J., Vilana R., Navasa M., Ayuso C., Boix L., Visa J., Rodés J. Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology. 1993 Nov;18(5):1121–1126. [PubMed] [Google Scholar]
  3. Cheah P. L., Looi L. M., Lin H. P., Yap S. F. Childhood primary hepatocellular carcinoma and hepatitis B virus infection. Cancer. 1990 Jan 1;65(1):174–176. doi: 10.1002/1097-0142(19900101)65:1<174::aid-cncr2820650133>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  4. Chlebowski R. T., Tong M., Weissman J., Block J. B., Ramming K. P., Weiner J. M., Bateman J. R., Chlebowski J. S. Hepatocellular carcinoma. Diagnostic and prognostic features in North American patients. Cancer. 1984 Jun 15;53(12):2701–2706. doi: 10.1002/1097-0142(19840615)53:12<2701::aid-cncr2820531224>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  5. Dunk A. A., Spiliadis H., Sherlock S., Fowler M. J., Monjardino J. P., Scheuer P. J., Thomas H. C. Hepatocellular carcinoma: clinical, aetiological and pathological features in British patients. Int J Cancer. 1988 Jan 15;41(1):17–23. doi: 10.1002/ijc.2910410105. [DOI] [PubMed] [Google Scholar]
  6. Falkson G., Cnaan A., Schutt A. J., Ryan L. M., Falkson H. C. Prognostic factors for survival in hepatocellular carcinoma. Cancer Res. 1988 Dec 15;48(24 Pt 1):7314–7318. [PubMed] [Google Scholar]
  7. Huvos A. G. Osteogenic sarcoma of bones and soft tissues in older persons. A clinicopathologic analysis of 117 patients older than 60 years. Cancer. 1986 Apr 1;57(7):1442–1449. doi: 10.1002/1097-0142(19860401)57:7<1442::aid-cncr2820570734>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  8. Lack E. E., Neave C., Vawter G. F. Hepatocellular carcinoma. Review of 32 cases in childhood and adolescence. Cancer. 1983 Oct 15;52(8):1510–1515. doi: 10.1002/1097-0142(19831015)52:8<1510::aid-cncr2820520830>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  9. Nomura F., Ohnishi K., Tanabe Y. Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Analysis of 606 patients. Cancer. 1989 Oct 15;64(8):1700–1707. doi: 10.1002/1097-0142(19891015)64:8<1700::aid-cncr2820640824>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  10. Okada S., Okazaki N., Nose H., Yoshimori M., Aoki K. Prognostic factors in patients with hepatocellular carcinoma receiving systemic chemotherapy. Hepatology. 1992 Jul;16(1):112–117. doi: 10.1002/hep.1840160119. [DOI] [PubMed] [Google Scholar]
  11. Okuda K. Early recognition of hepatocellular carcinoma. Hepatology. 1986 Jul-Aug;6(4):729–738. doi: 10.1002/hep.1840060432. [DOI] [PubMed] [Google Scholar]
  12. Okuda K., Ohtsuki T., Obata H., Tomimatsu M., Okazaki N., Hasegawa H., Nakajima Y., Ohnishi K. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer. 1985 Aug 15;56(4):918–928. doi: 10.1002/1097-0142(19850815)56:4<918::aid-cncr2820560437>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  13. Teeter S. M., Holmes F. F., McFarlane M. J. Lung carcinoma in the elderly population. Influence of histology on the inverse relationship of stage to age. Cancer. 1987 Sep 15;60(6):1331–1336. doi: 10.1002/1097-0142(19870915)60:6<1331::aid-cncr2820600628>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  14. Walker A., Schoenfeld E. R., Lowman J. T., Mettlin C. J., MacMillan J., Grufferman S. Survival of the older patient compared with the younger patient with Hodgkin's disease. Influence of histologic type, staging, and treatment. Cancer. 1990 Apr 1;65(7):1635–1640. doi: 10.1002/1097-0142(19900401)65:7<1635::aid-cncr2820650730>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  15. Yancik R., Ries L. G., Yates J. W. Breast cancer in aging women. A population-based study of contrasts in stage, surgery, and survival. Cancer. 1989 Mar 1;63(5):976–981. doi: 10.1002/1097-0142(19890301)63:5<976::aid-cncr2820630532>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  16. Yancik R., Ries L. G., Yates J. W. Ovarian cancer in the elderly: an analysis of Surveillance, Epidemiology, and End Results Program data. Am J Obstet Gynecol. 1986 Mar;154(3):639–647. doi: 10.1016/0002-9378(86)90623-x. [DOI] [PubMed] [Google Scholar]

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