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. 1995 Jan;71(1):64–68. doi: 10.1038/bjc.1995.13

Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1.

J Adélaide 1, G Monges 1, C Dérdérian 1, J F Seitz 1, D Birnbaum 1
PMCID: PMC2033462  PMID: 7819051

Abstract

The human CCND1/PRAD1 gene, located in the 11q13 chromosomal region, encodes a cyclin D protein with potential oncogenic capacity and is involved in several human malignancies. The amplification and expression status of CCND1 was investigated in a series of oesophageal tumours. CCND1 is amplified in 54% and overexpressed in 63% of the tumours of the squamous cell type.

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Selected References

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