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. 1994 Aug;70(2):315–318. doi: 10.1038/bjc.1994.299

Retention index of thallium-201 single photon emission computerised tomography (SPECT) as an indicator of metastasis in adenocarcinoma of the lung.

H Takekawa 1, K Itoh 1, S Abe 1, S Ogura 1, H Isobe 1, N Sukou 1, M Furudate 1, Y Kawakami 1
PMCID: PMC2033486  PMID: 8054281

Abstract

We examined the relationship between the retention of thallium-201 (201Tl) on a delayed scan and the metastatic potential of adenocarcinomas of the lung. We studied 43 patients with adenocarcinoma of the lung and divided them into two groups according to the presence or absence of lymph node metastasis. 201Tl single photon emission computerised tomography (SPECT) was conducted twice: 15 min (early scan) and 120 min (delayed scan) after intravenous injection of 3 mCi of 201Tl chloride. We calculated the retention index in order to evaluate the degree of 201Tl retention in the primary tumour. The retention indices were significantly higher in the group that was positive for lymph node metastasis than in the negative group. In adenocarcinomas with high metastatic potential, 201Tl SPECT demonstrated slow washout or increased retention on the delayed scan. The retention index of 201Tl SPECT is a useful indicator of metastatic potential, thereby facilitating the prediction of prognosis, and provides insight into the relationship between 201Tl uptake and malignancy. This is the first report demonstrating a significant relationship between the retention of 201Tl SPECT and lymph node metastasis.

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Selected References

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  1. Britten J. S., Blank M. Thallium activation of the (Na+--K+)-activated ATPase of rabbit kidney. Biochim Biophys Acta. 1968 Apr 24;159(1):160–166. doi: 10.1016/0005-2744(68)90254-4. [DOI] [PubMed] [Google Scholar]
  2. Cox P. H., Belfer A. J., van der Pompe W. B. Thallium 201 chloride uptake in tumours, a possible complication in heart scintigraphy. Br J Radiol. 1976 Sep;49(585):767–768. doi: 10.1259/0007-1285-49-585-767. [DOI] [PubMed] [Google Scholar]
  3. Hisada K., Tonami N., Miyamae T., Hiraki Y., Yamazaki T., Maeda T., Nakajo M. Clinical evaluation of tumor imaging with 201 TI chloride. Radiology. 1978 Nov;129(2):497–500. doi: 10.1148/129.2.497. [DOI] [PubMed] [Google Scholar]
  4. Itoh K., Takekawa H., Tsukamoto E., Nagao K., Nakada K., Abe S., Kawakami Y., Furudate M. Single photon emission computed tomography using 201Tl chloride in pulmonary nodules: comparison with 67Ga citrate and 99mTc-labeled hexamethylpropyleneamine-oxime. Ann Nucl Med. 1992 Nov;6(4):253–260. doi: 10.1007/BF03164663. [DOI] [PubMed] [Google Scholar]
  5. Kier A. B. Plasma membrane properties of cultured local LM cell tumors and metastases from athymic (nude) mice. Cancer Lett. 1990 Apr 9;50(1):19–30. doi: 10.1016/0304-3835(90)90174-v. [DOI] [PubMed] [Google Scholar]
  6. Lipford E. H., 3rd, Eggleston J. C., Lillemoe K. D., Sears D. L., Moore G. W., Baker R. R. Prognostic factors in surgically resected limited-stage, nonsmall cell carcinoma of the lung. Am J Surg Pathol. 1984 May;8(5):357–365. doi: 10.1097/00000478-198405000-00004. [DOI] [PubMed] [Google Scholar]
  7. Matsuno S., Tanabe M., Kawasaki Y., Satoh K., Urrutia A. E., Ohkawa M., Maeda M. Effectiveness of planar image and single photon emission tomography of thallium-201 compared with gallium-67 in patients with primary lung cancer. Eur J Nucl Med. 1992;19(2):86–95. doi: 10.1007/BF00184122. [DOI] [PubMed] [Google Scholar]
  8. Ochi H., Sawa H., Fukuda T., Inoue Y., Nakajima H., Masuda Y., Okamura T., Onoyama Y., Sugano S., Ohkita H. Thallium-201-chloride thyroid scintigraphy to evaluate benign and/or malignant nodules: usefulness of the delayed scan. Cancer. 1982 Jul 15;50(2):236–240. doi: 10.1002/1097-0142(19820715)50:2<236::aid-cncr2820500213>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  9. Salvatore M., Carratú L., Porta E. Thallium-201 as a positive indicator for lung neoplasms: preliminary experiments. Radiology. 1976 Nov;121(2):487–488. doi: 10.1148/121.2.487. [DOI] [PubMed] [Google Scholar]
  10. Shindo T., Okazaki T., Imui K., Wada H. [Clinical evaluation of 201Tl-scintigraphy with bronchial arterial administration]. Rinsho Hoshasen. 1985 Dec;30(13):1529–1536. [PubMed] [Google Scholar]
  11. Strauss H. W., Boucher C. A. Myocardial perfusion studies: lessons from a decade of clinical use. Radiology. 1986 Sep;160(3):577–584. doi: 10.1148/radiology.160.3.3526397. [DOI] [PubMed] [Google Scholar]
  12. Strauss H. W., Harrison K., Langan J. K., Lebowitz E., Pitt B. Thallium-201 for myocardial imaging. Relation of thallium-201 to regional myocardial perfusion. Circulation. 1975 Apr;51(4):641–645. doi: 10.1161/01.cir.51.4.641. [DOI] [PubMed] [Google Scholar]
  13. Suga K., Kume N., Orihashi N., Nishigauchi K., Uchisako H., Matsumoto T., Yamada N., Nakanishi T. Difference in 201Tl accumulation on single photon emission computed tomography in benign and malignant thoracic lesions. Nucl Med Commun. 1993 Dec;14(12):1071–1078. doi: 10.1097/00006231-199312000-00004. [DOI] [PubMed] [Google Scholar]
  14. Takise A., Kodama T., Shimosato Y., Watanabe S., Suemasu K. Histopathologic prognostic factors in adenocarcinomas of the peripheral lung less than 2 cm in diameter. Cancer. 1988 May 15;61(10):2083–2088. doi: 10.1002/1097-0142(19880515)61:10<2083::aid-cncr2820611025>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  15. Togawa T., Suzuki A., Kato K., Higuchi Y., Moriya H., Hoshi K., Kimura K., Kawaguchi T. Relation between 201Tl to 67Ga uptake ratio and histological type in primary lung cancer. Eur J Cancer Clin Oncol. 1985 Aug;21(8):925–930. doi: 10.1016/0277-5379(85)90109-9. [DOI] [PubMed] [Google Scholar]
  16. Tonami N., Shuke N., Yokoyama K., Seki H., Takayama T., Kinuya S., Nakajima K., Aburano T., Hisada K., Watanabe Y. Thallium-201 single photon emission computed tomography in the evaluation of suspected lung cancer. J Nucl Med. 1989 Jun;30(6):997–1004. [PubMed] [Google Scholar]
  17. el-Desouki M. Tl-201 thyroid imaging in differentiating benign from malignant thyroid nodules. Clin Nucl Med. 1991 Jun;16(6):425–430. doi: 10.1097/00003072-199106000-00010. [DOI] [PubMed] [Google Scholar]

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