Abstract
Eleven survivors of pelvic rhabdomyosarcoma underwent bladder function studies and upper urinary tract evaluation at a mean of 6.6 years after completion of therapy, which included a conservative, bladder-sparing surgical policy. Primary tumour sites were: bladder base/prostate, 6; bladder dome, 1; vagina, 2; and pelvic side wall, 2. Seven children (five bladder base/prostate, one vagina and one pelvic side wall tumours) had received irradiation to the pelvis with external beam alone, brachytherapy or both. All seven of these patients had markedly reduced functional bladder capacity (11-48% of mean expected value for age) and abnormal voiding patterns, though bladder compliance was not reduced and bladder emptying was almost complete in five cases. Four of these children also had upper tract dilatation and two required reconstructive bladder surgery because of severe bilateral hydronephrosis. By contrast, each of four children treated without radiotherapy had a normal functional bladder capacity and a normal voiding pattern. all survivors of pelvic rhabdomyosarcoma, especially those who have received radiotherapy, should be carefully monitored for dysfunction of both lower and upper urinary tracts. The frequency-volume voiding chart is a sensitive and easily accomplished method of assessing bladder function in these patients.
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- Atra A., Ward H. C., Aitken K., Boyle M., Dicks-Mireaux C., Duffy P. G., Mitchell C. D., Plowman P. N., Ransley P. G., Pritchard J. Conservative surgery in multimodal therapy for pelvic rhabdomyosarcoma in children. Br J Cancer. 1994 Nov;70(5):1004–1008. doi: 10.1038/bjc.1994.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Broecker B. H., Plowman N., Pritchard J., Ransley P. G. Pelvic rhabdomyosarcoma in children. Br J Urol. 1988 May;61(5):427–431. doi: 10.1111/j.1464-410x.1988.tb06590.x. [DOI] [PubMed] [Google Scholar]
- Crist W. M., Garnsey L., Beltangady M. S., Gehan E., Ruymann F., Webber B., Hays D. M., Wharam M., Maurer H. M. Prognosis in children with rhabdomyosarcoma: a report of the intergroup rhabdomyosarcoma studies I and II. Intergroup Rhabdomyosarcoma Committee. J Clin Oncol. 1990 Mar;8(3):443–452. doi: 10.1200/JCO.1990.8.3.443. [DOI] [PubMed] [Google Scholar]
- Ghavimi F., Herr H., Jereb B., Exelby P. R. Treatment of genitourinary rhabdomyosarcoma in children. J Urol. 1984 Aug;132(2):313–319. doi: 10.1016/s0022-5347(17)49607-8. [DOI] [PubMed] [Google Scholar]
- Grosfeld J. L., Weber T. R., Weetman R. M., Baehner R. L. Rhabdomyosarcoma in childhood: analysis of survival in 98 cases. J Pediatr Surg. 1983 Apr;18(2):141–146. doi: 10.1016/s0022-3468(83)80536-3. [DOI] [PubMed] [Google Scholar]
- Hays D. M., Lawrence W., Jr, Crist W. M., Wiener E., Raney R. B., Jr, Ragab A., Tefft M., Webber B., Johnston J., Maurer H. M. Partial cystectomy in the management of rhabdomyosarcoma of the bladder: a report from the Intergroup Rhabdomyosarcoma Study. J Pediatr Surg. 1990 Jul;25(7):719–723. doi: 10.1016/s0022-3468(05)80004-1. [DOI] [PubMed] [Google Scholar]
- Hays D. M., Raney R. B., Jr, Lawrence W., Jr, Tefft M., Soule E. H., Crist W. M., Foulkes M., Maurer H. M. Primary chemotherapy in the treatment of children with bladder--prostate tumors in the Intergroup Rhabdomyosarcoma Study (IRS-II). J Pediatr Surg. 1982 Dec;17(6):812–820. doi: 10.1016/s0022-3468(82)80449-1. [DOI] [PubMed] [Google Scholar]
- Koff S. A. Estimating bladder capacity in children. Urology. 1983 Mar;21(3):248–248. doi: 10.1016/0090-4295(83)90079-1. [DOI] [PubMed] [Google Scholar]
- La Quaglia M. P., Ghavimi F., Herr H., Mandell L., Pennenberg D., Hajdu S., Exelby P. R. Prognostic factors in bladder and bladder-prostate rhabdomyosarcoma. J Pediatr Surg. 1990 Oct;25(10):1066–1072. doi: 10.1016/0022-3468(90)90220-4. [DOI] [PubMed] [Google Scholar]
- Massad C. A., Kogan B. A., Ablin A. R. Organ preservation in the management of pelvic rhabdomyosarcoma. Urol Int. 1991;46(3):279–282. doi: 10.1159/000282151. [DOI] [PubMed] [Google Scholar]
- Maurer H. M., Beltangady M., Gehan E. A., Crist W., Hammond D., Hays D. M., Heyn R., Lawrence W., Newton W., Ortega J. The Intergroup Rhabdomyosarcoma Study-I. A final report. Cancer. 1988 Jan 15;61(2):209–220. doi: 10.1002/1097-0142(19880115)61:2<209::aid-cncr2820610202>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
- McLorie G. A., Abara O. E., Churchill B. M., Greenberg M., Mancer K. Rhabdomyosarcoma of the prostate in childhood: current challenges. J Pediatr Surg. 1989 Oct;24(10):977–981. doi: 10.1016/s0022-3468(89)80196-4. [DOI] [PubMed] [Google Scholar]
- Ortega J. A. A therapeutic approach to childhood pelvic rhabdomyosarcoma without pelvic exenteration. J Pediatr. 1979 Feb;94(2):205–209. doi: 10.1016/s0022-3476(79)80824-0. [DOI] [PubMed] [Google Scholar]
- Raney R. B., Jr, Gehan E. A., Hays D. M., Tefft M., Newton W. A., Jr, Haeberlen V., Maurer H. M. Primary chemotherapy with or without radiation therapy and/or surgery for children with localized sarcoma of the bladder, prostate, vagina, uterus, and cervix. A comparison of the results in Intergroup Rhabdomyosarcoma Studies I and II. Cancer. 1990 Nov 15;66(10):2072–2081. doi: 10.1002/1097-0142(19901115)66:10<2072::aid-cncr2820661006>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
- Tefft M., Hays D., Raney R. B., Jr, Lawrence W., Soule E., Donaldson M. H., Sutow W. W., Gehan E. Radiation to regional nodes for rhabdomyosarcoma of the genitourinary tract in children: is it necessary? A report from the Intergroup Rhabdomyosarcoma Study No. 1 (IRS-1). Cancer. 1980 Jun 15;45(12):3065–3068. doi: 10.1002/1097-0142(19800615)45:12<3065::aid-cncr2820451231>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
- Voûte P. A., Vos A., de Kraker J., Behrendt H. Rhabdomyosarcomas: chemotherapy and limited supplementary treatment program to avoid mutilation. Natl Cancer Inst Monogr. 1981 Apr;(56):121–125. [PubMed] [Google Scholar]