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. 1995 Apr;71(4):894–897. doi: 10.1038/bjc.1995.172

Cervical cytology reported as negative and risk of adenocarcinoma of the cervix: no strong evidence of benefit.

H Mitchell 1, G Medley 1, I Gordon 1, G Giles 1
PMCID: PMC2033741  PMID: 7710961

Abstract

The relationship between negative cervical cytology reports and risk of adenocarcinoma of the cervix was evaluated in a case-control study of 113 cases and 452 controls. All cases and controls had received at least two negative cytology reports. There was no significant difference between the cases and controls in the number of negative cytology reports or in history of cervical abnormality; while a test for trend in the time since last negative cytology report was significant (P < 0.001), the estimated benefit was very modest. Although the estimates of relative protection were higher in women aged less than 35 years than in women aged 35-69 years, this difference was not statistically significant. These results suggest that cervical screening as practised in the 1970s and 1980s was much less effective in preventing adenocarcinoma than squamous carcinoma of the cervix.

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Selected References

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  1. Anderson M. C., Fraser A. C. Adenocarcinoma of the uterine cervix a clinical and pathological appraisal. Br J Obstet Gynaecol. 1976 Apr;83(4):320–325. doi: 10.1111/j.1471-0528.1976.tb00834.x. [DOI] [PubMed] [Google Scholar]
  2. Bowman J. A., Redman S., Dickinson J. A., Gibberd R., Sanson-Fisher R. W. The accuracy of Pap smear utilization self-report: a methodological consideration in cervical screening research. Health Serv Res. 1991 Apr;26(1):97–107. [PMC free article] [PubMed] [Google Scholar]
  3. Boyce J. G., Fruchter R. G., Romanzi L., Sillman F. H., Maiman M. The fallacy of the screening interval for cervical smears. Obstet Gynecol. 1990 Oct;76(4):627–632. [PubMed] [Google Scholar]
  4. Brinton L. A., Tashima K. T., Lehman H. F., Levine R. S., Mallin K., Savitz D. A., Stolley P. D., Fraumeni J. F., Jr Epidemiology of cervical cancer by cell type. Cancer Res. 1987 Mar 15;47(6):1706–1711. [PubMed] [Google Scholar]
  5. Celentano D. D., Klassen A. C., Weisman C. S., Rosenshein N. B. Duration of relative protection of screening for cervical cancer. Prev Med. 1989 Jul;18(4):411–422. doi: 10.1016/0091-7435(89)90001-7. [DOI] [PubMed] [Google Scholar]
  6. Chilvers C., Mant D., Pike M. C. Cervical adenocarcinoma and oral contraceptives. Br Med J (Clin Res Ed) 1987 Dec 5;295(6611):1446–1447. doi: 10.1136/bmj.295.6611.1446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cohen M. M. Using administrative data for case-control studies: the case of the Papanicolaou smear. Ann Epidemiol. 1993 Jan;3(1):93–98. doi: 10.1016/1047-2797(93)90015-v. [DOI] [PubMed] [Google Scholar]
  8. Dallenbach-Hellweg G. On the origin and histological structure of adenocarcinoma of the endocervix in women under 50 years of age. Pathol Res Pract. 1984 Sep;179(1):38–50. doi: 10.1016/S0344-0338(84)80059-X. [DOI] [PubMed] [Google Scholar]
  9. Hurt W. G., Silverberg S. G., Frable W. J., Belgrad R., Crooks L. D. Adenocarcinoma of the cervix: histopathologic and clinical features. Am J Obstet Gynecol. 1977 Oct 1;129(3):304–315. doi: 10.1016/0002-9378(77)90788-8. [DOI] [PubMed] [Google Scholar]
  10. Klassen A. C., Celentano D. D., Brookmeyer R. Variation in the duration of protection given by screening using the Pap test for cervical cancer. J Clin Epidemiol. 1989;42(10):1003–1011. doi: 10.1016/0895-4356(89)90166-2. [DOI] [PubMed] [Google Scholar]
  11. La Vecchia C., Franceschi S., Decarli A., Fasoli M., Gentile A., Tognoni G. "Pap" smear and the risk of cervical neoplasia: quantitative estimates from a case-control study. Lancet. 1984 Oct 6;2(8406):779–782. doi: 10.1016/s0140-6736(84)90705-0. [DOI] [PubMed] [Google Scholar]
  12. Macgregor J. E., Moss S. M., Parkin D. M., Day N. E. A case-control study of cervical cancer screening in north east Scotland. Br Med J (Clin Res Ed) 1985 May 25;290(6481):1543–1546. doi: 10.1136/bmj.290.6481.1543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mitchell H., Medley G. Cytological reporting of cervical abnormalities according to endocervical status. Br J Cancer. 1993 Mar;67(3):585–588. doi: 10.1038/bjc.1993.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Olesen F. A case-control study of cervical cytology before diagnosis of cervical cancer in Denmark. Int J Epidemiol. 1988 Sep;17(3):501–508. doi: 10.1093/ije/17.3.501. [DOI] [PubMed] [Google Scholar]
  15. Parazzini F., La Vecchia C., Negri E., Fasoli M., Cecchetti G. Risk factors for adenocarcinoma of the cervix: a case-control study. Br J Cancer. 1988 Feb;57(2):201–204. doi: 10.1038/bjc.1988.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Peters R. K., Chao A., Mack T. M., Thomas D., Bernstein L., Henderson B. E. Increased frequency of adenocarcinoma of the uterine cervix in young women in Los Angeles County. J Natl Cancer Inst. 1986 Mar;76(3):423–428. [PubMed] [Google Scholar]
  17. Rombaut R. P., Charles D., Murphy A. Adenocarcinoma of the cervix. A clinicopathologic study of 47 cases. Cancer. 1966 Jul;19(7):891–900. doi: 10.1002/1097-0142(196607)19:7<891::aid-cncr2820190702>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  18. Sawyer J. A., Earp J. A., Fletcher R. H., Daye F. F., Wynn T. M. Accuracy of women's self-report of their last Pap smear. Am J Public Health. 1989 Aug;79(8):1036–1037. doi: 10.2105/ajph.79.8.1036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Schwartz S. M., Weiss N. S. Increased incidence of adenocarcinoma of the cervix in young women in the United States. Am J Epidemiol. 1986 Dec;124(6):1045–1047. doi: 10.1093/oxfordjournals.aje.a114474. [DOI] [PubMed] [Google Scholar]
  20. Shy K., Chu J., Mandelson M., Greer B., Figge D. Papanicolaou smear screening interval and risk of cervical cancer. Obstet Gynecol. 1989 Dec;74(6):838–843. [PubMed] [Google Scholar]
  21. Silcocks P. B., Thornton-Jones H., Murphy M. Squamous and adenocarcinoma of the uterine cervix: a comparison using routine data. Br J Cancer. 1987 Mar;55(3):321–325. doi: 10.1038/bjc.1987.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Walter S. D., Clarke E. A., Hatcher J., Stitt L. W. A comparison of physician and patient reports of Pap smear histories. J Clin Epidemiol. 1988;41(4):401–410. doi: 10.1016/0895-4356(88)90148-5. [DOI] [PubMed] [Google Scholar]
  23. van der Graaf Y., Zielhuis G. A., Peer P. G., Vooijs P. G. The effectiveness of cervical screening: a population-based case-control study. J Clin Epidemiol. 1988;41(1):21–26. doi: 10.1016/0895-4356(88)90005-4. [DOI] [PubMed] [Google Scholar]

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