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. 1995 Apr;71(4):705–711. doi: 10.1038/bjc.1995.138

The interaction with tubulin of a series of stilbenes based on combretastatin A-4.

J A Woods 1, J A Hadfield 1, G R Pettit 1, B W Fox 1, A T McGown 1
PMCID: PMC2033763  PMID: 7710932

Abstract

A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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