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. 1995 May;71(5):1029–1032. doi: 10.1038/bjc.1995.198

Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?

P Hietanen 1, C Blomqvist 1, V M Wasenius 1, E Niskanen 1, K Franssila 1, S Nordling 1
PMCID: PMC2033766  PMID: 7734295

Abstract

The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients. The response to chemotherapy was significantly better in patients with tumours with a high SPF, and in addition the time to progression was longer in the high-SPF group. There was no significant difference when the DNA ploidy and response to treatment were compared.

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Selected References

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