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. 1995 Oct;72(4):976–980. doi: 10.1038/bjc.1995.445

Are Japanese and European gastric cancer the same biological entity? An immunohistochemical study.

J I Livingstone 1, W Yasui 1, E Tahara 1, C Wastell 1
PMCID: PMC2034064  PMID: 7547252

Abstract

To examine the suggested biological difference between Japanese and British gastric cancers, immunohistochemistry was used to demonstrate eight markers of biological activity in a matched series of 40 Japanese and 33 British cases. There were no differences in the proportions of Japanese and British tumours positive to epidermal growth factor, epidermal growth factor receptor, transforming growth factor alpha, cripto or p53. A significantly greater proportion of British tumours were positive to c-erbB-2 whilst a significantly greater proportion of Japanese tumours were positive to nm23. British tumours had a significantly greater mean proliferating cell nuclear antigen proliferation index than Japanese tumours. These differences could be clinically significant.

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Selected References

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  1. Ayhan A., Yasui W., Yokozaki H., Kitadai Y., Tahara E. Reduced expression of nm23 protein is associated with advanced tumor stage and distant metastases in human colorectal carcinomas. Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;63(4):213–218. doi: 10.1007/BF02899264. [DOI] [PubMed] [Google Scholar]
  2. Bevilacqua G., Sobel M. E., Liotta L. A., Steeg P. S. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res. 1989 Sep 15;49(18):5185–5190. [PubMed] [Google Scholar]
  3. Cady B., Rossi R. L., Silverman M. L., Piccione W., Heck T. A. Gastric adenocarcinoma. A disease in transition. Arch Surg. 1989 Mar;124(3):303–308. doi: 10.1001/archsurg.1989.01410030049009. [DOI] [PubMed] [Google Scholar]
  4. Carpenter G., Cohen S. Epidermal growth factor. Annu Rev Biochem. 1979;48:193–216. doi: 10.1146/annurev.bi.48.070179.001205. [DOI] [PubMed] [Google Scholar]
  5. Ciccodicola A., Dono R., Obici S., Simeone A., Zollo M., Persico M. G. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J. 1989 Jul;8(7):1987–1991. doi: 10.1002/j.1460-2075.1989.tb03605.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Filipe M. I., Mendes R., Lane D. P., Morris R. W. Assessment of proliferating cell nuclear antigen expression in precursor stages of gastric carcinoma using the PC10 antibody to PCNA. Histopathology. 1993 Apr;22(4):349–354. doi: 10.1111/j.1365-2559.1993.tb00134.x. [DOI] [PubMed] [Google Scholar]
  7. Galand P., Degraef C. Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues. Cell Tissue Kinet. 1989 Sep;22(5):383–392. doi: 10.1111/j.1365-2184.1989.tb00223.x. [DOI] [PubMed] [Google Scholar]
  8. Gullick W. J., Love S. B., Wright C., Barnes D. M., Gusterson B., Harris A. L., Altman D. G. c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes. Br J Cancer. 1991 Mar;63(3):434–438. doi: 10.1038/bjc.1991.100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hall P. A., Levison D. A., Woods A. L., Yu C. C., Kellock D. B., Watkins J. A., Barnes D. M., Gillett C. E., Camplejohn R., Dover R. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol. 1990 Dec;162(4):285–294. doi: 10.1002/path.1711620403. [DOI] [PubMed] [Google Scholar]
  10. Hollstein M., Sidransky D., Vogelstein B., Harris C. C. p53 mutations in human cancers. Science. 1991 Jul 5;253(5015):49–53. doi: 10.1126/science.1905840. [DOI] [PubMed] [Google Scholar]
  11. Jain S., Filipe M. I., Gullick W. J., Linehan J., Morris R. W. c-erbB-2 proto-oncogene expression and its relationship to survival in gastric carcinoma: an immunohistochemical study on archival material. Int J Cancer. 1991 Jul 9;48(5):668–671. doi: 10.1002/ijc.2910480506. [DOI] [PubMed] [Google Scholar]
  12. Jain S., Filipe M. I., Hall P. A., Waseem N., Lane D. P., Levison D. A. Prognostic value of proliferating cell nuclear antigen in gastric carcinoma. J Clin Pathol. 1991 Aug;44(8):655–659. doi: 10.1136/jcp.44.8.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kampschöer G. H., Nakajima T., van de Velde C. J. Changing patterns in gastric adenocarcinoma. Br J Surg. 1989 Sep;76(9):914–916. doi: 10.1002/bjs.1800760913. [DOI] [PubMed] [Google Scholar]
  14. Kuniyasu H., Yoshida K., Yokozaki H., Yasui W., Ito H., Toge T., Ciardiello F., Persico M. G., Saeki T., Salomon D. S. Expression of cripto, a novel gene of the epidermal growth factor family, in human gastrointestinal carcinomas. Jpn J Cancer Res. 1991 Sep;82(9):969–973. doi: 10.1111/j.1349-7006.1991.tb01929.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Leone A., Flatow U., King C. R., Sandeen M. A., Margulies I. M., Liotta L. A., Steeg P. S. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell. 1991 Apr 5;65(1):25–35. doi: 10.1016/0092-8674(91)90404-m. [DOI] [PubMed] [Google Scholar]
  16. Leone A., McBride O. W., Weston A., Wang M. G., Anglard P., Cropp C. S., Goepel J. R., Lidereau R., Callahan R., Linehan W. M. Somatic allelic deletion of nm23 in human cancer. Cancer Res. 1991 May 1;51(9):2490–2493. [PubMed] [Google Scholar]
  17. Livingstone J. I., Filipe M. I., Wastell C. Expression of transforming growth factor alpha in experimental gastric carcinogenesis. Gut. 1994 May;35(5):604–607. doi: 10.1136/gut.35.5.604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Miyachi K., Fritzler M. J., Tan E. M. Autoantibody to a nuclear antigen in proliferating cells. J Immunol. 1978 Dec;121(6):2228–2234. [PubMed] [Google Scholar]
  19. Nagata T., Ikeda M., Nakayama F. Changing state of gastric cancer in Japan. Histologic perspective of the past 76 years. Am J Surg. 1983 Feb;145(2):226–233. doi: 10.1016/0002-9610(83)90068-5. [DOI] [PubMed] [Google Scholar]
  20. Nakayama H., Yasui W., Yokozaki H., Tahara E. Reduced expression of nm23 is associated with metastasis of human gastric carcinomas. Jpn J Cancer Res. 1993 Feb;84(2):184–190. doi: 10.1111/j.1349-7006.1993.tb02853.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Prelich G., Stillman B. Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA. Cell. 1988 Apr 8;53(1):117–126. doi: 10.1016/0092-8674(88)90493-x. [DOI] [PubMed] [Google Scholar]
  22. Rowlands D. C., Brown H. E., Barber P. C., Jones E. L. The effect of tissue fixation on immunostaining for proliferating cell nuclear antigen with the monoclonal antibody PC10. J Pathol. 1991 Dec;165(4):356–357. doi: 10.1002/path.1711650415. [DOI] [PubMed] [Google Scholar]
  23. Sasaki K., Tomita Y., Azuma M., Shida S., Simizu B. Amplification and overexpression of the c-erbB-2 protooncogene in human gastric cancer. Gastroenterol Jpn. 1992 Apr;27(2):172–178. doi: 10.1007/BF02777719. [DOI] [PubMed] [Google Scholar]
  24. Sporn M. B., Todaro G. J. Autocrine secretion and malignant transformation of cells. N Engl J Med. 1980 Oct 9;303(15):878–880. doi: 10.1056/NEJM198010093031511. [DOI] [PubMed] [Google Scholar]
  25. Steeg P. S., Bevilacqua G., Kopper L., Thorgeirsson U. P., Talmadge J. E., Liotta L. A., Sobel M. E. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst. 1988 Apr 6;80(3):200–204. doi: 10.1093/jnci/80.3.200. [DOI] [PubMed] [Google Scholar]
  26. Sugiyama K., Yonemura Y., Miyazaki I. Immunohistochemical study of epidermal growth factor and epidermal growth factor receptor in gastric carcinoma. Cancer. 1989 Apr 15;63(8):1557–1561. doi: 10.1002/1097-0142(19890415)63:8<1557::aid-cncr2820630818>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  27. Tahara E., Sumiyoshi H., Hata J., Yasui W., Taniyama K., Hayashi T., Nagae S., Sakamoto S. Human epidermal growth factor in gastric carcinoma as a biologic marker of high malignancy. Jpn J Cancer Res. 1986 Feb;77(2):145–152. [PubMed] [Google Scholar]
  28. Takeda J., Hashimoto K., Koufuji K., Kodama I., Aoyagi K., Kakegawa T. A retrospective study of resected gastric cancers. Kurume Med J. 1992;39(3):141–145. doi: 10.2739/kurumemedj.39.141. [DOI] [PubMed] [Google Scholar]
  29. Tateishi M., Toda T., Minamisono Y., Nagasaki S. Clinicopathological significance of c-erbB-2 protein expression in human gastric carcinoma. J Surg Oncol. 1992 Apr;49(4):209–212. doi: 10.1002/jso.2930490402. [DOI] [PubMed] [Google Scholar]
  30. Vinson C. R., Sigler P. B., McKnight S. L. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science. 1989 Nov 17;246(4932):911–916. doi: 10.1126/science.2683088. [DOI] [PubMed] [Google Scholar]
  31. Yamamoto T., Ikawa S., Akiyama T., Semba K., Nomura N., Miyajima N., Saito T., Toyoshima K. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature. 1986 Jan 16;319(6050):230–234. doi: 10.1038/319230a0. [DOI] [PubMed] [Google Scholar]
  32. Yasui W., Sumiyoshi H., Hata J., Kameda T., Ochiai A., Ito H., Tahara E. Expression of epidermal growth factor receptor in human gastric and colonic carcinomas. Cancer Res. 1988 Jan 1;48(1):137–141. [PubMed] [Google Scholar]
  33. Yonemura Y., Takamura H., Ninomiya I., Fushida S., Tsugawa K., Kaji M., Nakai Y., Ohoyama S., Yamaguchi A., Miyazaki I. Interrelationship between transforming growth factor-alpha and epidermal growth factor receptor in advanced gastric cancer. Oncology. 1992;49(2):157–161. doi: 10.1159/000227031. [DOI] [PubMed] [Google Scholar]
  34. Yu C. C., Fletcher C. D., Newman P. L., Goodlad J. R., Burton J. C., Levison D. A. A comparison of proliferating cell nuclear antigen (PCNA) immunostaining, nucleolar organizer region (AgNOR) staining, and histological grading in gastrointestinal stromal tumours. J Pathol. 1992 Feb;166(2):147–152. doi: 10.1002/path.1711660210. [DOI] [PubMed] [Google Scholar]
  35. del Giglio A., O'Brien S., Ford R., Saya H., Manning J., Keating M., Johnston D., Khetan R., el-Naggar A., Deisseroth A. Prognostic value of proliferating cell nuclear antigen expression in chronic lymphoid leukemia. Blood. 1992 May 15;79(10):2717–2720. [PubMed] [Google Scholar]
  36. van Dierendonck J. H., Wijsman J. H., Keijzer R., van de Velde C. J., Cornelisse C. J. Cell-cycle-related staining patterns of anti-proliferating cell nuclear antigen monoclonal antibodies. Comparison with BrdUrd labeling and Ki-67 staining. Am J Pathol. 1991 May;138(5):1165–1172. [PMC free article] [PubMed] [Google Scholar]

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