TABLE 4.
Ity3 interval specific oligonucleotide array list of differentially regulated genes on chromosome 1 in spleen
| Up/downa | Accession ID | Gene name | Position (Mb)b | Fold change (average ± SEM) | Function |
|---|---|---|---|---|---|
| Day 1 | |||||
| Up | NM_172842 | Lax1 | c | 2.7 ± 0.7 | Regulates TCR/BCR signaling |
| NM_009741 | Bcl2 | 108.4 | 2.3 ± 0.2 | Suppresses apoptosis | |
| Day 3 | |||||
| Up | NM_007695 | Chi3l1 | 136.0 | 2.4 ± 0.3 | Bacterial adhesion/invasion |
| Day 5 | |||||
| Up | NM_145512 | Sft2d2 | 167.0 | 2.4 ± 0.2 | Retrograde vesicle transport |
| NM_022018 | Niban | 153.3 | 2.3 ± 0.2 | Unknown | |
| NM_02876 | 1190005F20Rik | 153.2 | 2.3 ± 0.3 | N(2),N(2)-dimethylguanosine tRNA methyltransferase | |
| NM_025819 | 1200016B10Rik | 153.1 | 2.2 ± 0.1 | Unknown | |
| NM_145991 | Cdc73 | 145.4 | 2.2 ± 0.4 | Tumor suppressor; cell cycle regulation | |
| NM_010709 | Lgtn | 133.0 | 2.1 ± 0.2 | Trafficking receptor for phosphoglycoproteins | |
| NM_172517 | Rbbp5 | 134.3 | 2.1 ± 0.4 | Binds retinoblastoma protein | |
| Down | NM_144960 | Fcamr | 132.6 | −3.7 ± 1.1 | Fc receptor (IgA, IgM) |
a
Up- or downregulated in B6.MOLF-Ity/Ity3 compared to B6.MOLF-Ity/Ity3MOLF/B6.
b
Physical map positions based on Ensembl build 39.
c
Physical map position is unknown on the basis of Ensembl build 39; however, it is syntenic to human 1q32.1, corresponding to a region around 135 Mb on mouse chromosome 1.