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. 1987 Aug;53(8):1780–1784. doi: 10.1128/aem.53.8.1780-1784.1987

Microbial transformation of precocene II: oxidative reactions by Streptomyces griseus.

F S Sariaslani 1, L R McGee 1, D W Ovenall 1
PMCID: PMC203998  PMID: 3116933

Abstract

Various species of "Streptomyces," "Aspergillus," "Rhodotorula," "Brevilegnia," "Syncephalastrum," and "Stysanus" were found to transform precocene II to three major metabolites. These major biotransformation products were isolated from a preparative-scale incubation of precocene II with Streptomyces griseus and were conclusively identified as (-)cis- and (+)trans-precocene II-3,4-dihydrodiols and (+)-3-chromenol. 18O2 incorporation studies indicated the involvement of a monooxygenase enzyme system in precocene II transformation by S. griseus. A mechanism is proposed for the formation of (+)-3-chromenol.

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Selected References

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