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Mutational analysis for Ras (n = 23), Tp53, and EGFR (n = 32) in tumor DNA extracts. (A) No mutations were found in K-ras, N-ras, c-H-ras, or EGFR in any of the silica-induced tumors analyzed after microdissection. For Tp53, five mutations were found in three tumors of 32 cases analyzed (9%). (B) Electropherogram of the DNA sequence of the tumor (mt) versus the corresponding adjacent normal tissue (wt) showing the mutations found in exon 5 in AC and exon 6 in SCC.
